“…Snast et al, in their recent meta-analysis for non-surgical treatments for EMPD, have reviewed the efficiency of the options available in the literature, specifically radiotherapy, photodynamic therapy (PDT), laser therapy, immune response modifiers, and locally applied creams [ 16 ]. Radiation is mostly used in elderly patients where comorbidities do not allow surgical intervention, in combination with surgical treatments as adjuvant radiation [ 13 ], or in difficult anatomic areas where complete excision of the lesion is not feasible [ 16 , 20 , 21 ]. Laser ablation (CO 2 , holmium, argon dye) has been used on several occasions; nevertheless, high local recurrence rates have been reported and patients complain of severe pain [ 13 , 16 , 20 , 21 ].…”