1986
DOI: 10.1016/0020-711x(86)90077-7
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Nontransferrin-bound serum iron in thalassemia and sickle cell patients

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Cited by 13 publications
(5 citation statements)
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“…The present assay differs fundamentally from previously published assays for the determination of serum NTBI, a component found in sera of patients with various Fe-overload conditions and imbalances of Fe metabolism. [6][7][8][9][10] Whereas assays for NTBI use mobilizing agents for rendering the NTBI accessible to a chelator or probe, the method presented here does not. The distinctive feature of this approach is that only the directly DFO-accessible fraction of serum Fe is detected.…”
Section: Discussionmentioning
confidence: 99%
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“…The present assay differs fundamentally from previously published assays for the determination of serum NTBI, a component found in sera of patients with various Fe-overload conditions and imbalances of Fe metabolism. [6][7][8][9][10] Whereas assays for NTBI use mobilizing agents for rendering the NTBI accessible to a chelator or probe, the method presented here does not. The distinctive feature of this approach is that only the directly DFO-accessible fraction of serum Fe is detected.…”
Section: Discussionmentioning
confidence: 99%
“…These are evidently artifactual, although they have also been obtained in other NTBI tests. [8][9][10]20,21 Although the source of the negative values is unclear, they are apparently due to the removal of contaminant Fe by the Fe-binding activity in the sera, as illustrated in Figures 4 and 8, where the addition of apo-Tf or DFO to the samples caused the generation of negative values. Therefore all concentrations less than 0.3 M were considered DCI-negative, and this zero value is indicated by dashed lines in the figures.…”
Section: Methodologic Aspects Of the DCI Assaymentioning
confidence: 99%
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“…As a result of iron overload, high levels of plasma iron in the form of nontransferrin bound iron (NTBI) can be found in both transfusion-dependent and transfusion-independent thalassemia patients. 7 NTBI plays a crucial role in the production of hydroxyl radicals (HO • ) in vivo that occurs through the biological Fenton-type and Haber-Weiss reactions. The resulting hydroxyl radicals can induce oxidative stress and, as a consequence, damage of cellular nucleic acids, proteins, lipids and carbohydrates, which in turn can potentiate tissue damage.…”
mentioning
confidence: 99%