Nontraumatic Rhabdomyolysis with Long-Term Alcohol Intoxication

Qiu, Ling L.; Nalin, Peter; Huffman, Qin; Sneed, Jerome B.; Renshaw, Scott; Hartman, Steven W.

doi:10.3122/jabfm.17.1.54

Cited by 21 publications

(14 citation statements)

References 24 publications

(25 reference statements)

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“…Rhabdomyolysis may also occur secondary to chronic alcohol intake [31]. The proposed mechanism for rhabdomyolysis due to chronic alcoholism are electrolyte disturbances like hypokalemia, hypophosphatemia and hypomagnesemia as evidenced by marked depletion of intracellular potassium, phosphorus and magnesium in skeletal muscles of chronic alcoholics and experimental animals fed with alcohol [32], [33].…”

Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis in Community Acquired Bacterial Sepsis – A Retrospective Cohort Study

et al. 2009

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Background and ObjectivesRhabdomyolysis is often associated with sepsis and gram positive bacterial pathogens are reported to be the most frequent cause of sepsis induced rhabdomyolysis. We report the pattern of infecting bacterial pathogens and associated causal factors in a South-Indian cohort.Design, Setting, Participants & MeasurementsRetrospective cohort study of adult patients with community acquired bacterial sepsis complicated by rhabdomyolysis from March 2003 - August 2008. Rhabdomyolysis was defined as serum creatine kinase >2000 IU/L. The study population was divided into group-I (sepsis with gram positive pathogens), group–II (sepsis with gram negative pathogens) and group-III (culture negative sepsis).Results103 patients (group I -15, group II- 34 and group III- 54) formed the study cohort. Mean age was 55 years and two-third had diabetes. Mean creatine kinase was 7114 IU/L and mean serum creatinine on admission was 2.4 mg/dl. Causative pathogen of sepsis was identified in 47.5%. Gram negative pathogens were more frequently (33%) associated with rhabdomyolysis than gram positive pathogens (14.5%). Lung was the commonest foci of sepsis (38.8%). 78.6% of the study population had one or more additional causal factor for rhabdomyolysis like statin intake, chronic alcoholism, hypokalemia, hypernatremia and hypophosphatemia. Mortality was 59%.ConclusionsGram negative bacterial pathogens were more frequently associated with rhabdomyolysis than gram positive pathogens. Rhabdomyolysis in patients with sepsis is multifactorial and is associated with high mortality.

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Section: Discussionmentioning

confidence: 99%

Rhabdomyolysis in Community Acquired Bacterial Sepsis – A Retrospective Cohort Study

et al. 2009

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“…Pharmaceutical agents, alcohol, and illicit drugs are significant causes of rhabdomyolysis 1 . In many cases of alcohol-related nontraumatic rhabdomyolysis reported in the literature, patients have a typical history of short-term alcohol intoxication and alcohol-induced coma or immobilization 2 . These patients are commonly diagnosed and treated in emergency settings because of a rapid onset of severe muscle pain and decreased urine output 2 .…”

Section: Introductionmentioning

confidence: 99%

“…In many cases of alcohol-related nontraumatic rhabdomyolysis reported in the literature, patients have a typical history of short-term alcohol intoxication and alcohol-induced coma or immobilization 2 . These patients are commonly diagnosed and treated in emergency settings because of a rapid onset of severe muscle pain and decreased urine output 2 . The outcomes following rhabdomyolysis are similarly variable, ranging from asymptomatic elevations of CPK concentration to life-threatening electrolyte abnormalities and acute renal failure (ARF) requiring hemodialysis or continuous renal replacement therapy 3 .…”

Section: Introductionmentioning

confidence: 99%

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Papadatos

Deligiannis

Bazoukis

et al. 2015

Clinical Case Reports

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“…In alcohol-related RML reported in the literature, most patients have a typical history of short-term alcohol intoxication with sedation, immobilization or alcohol-induced coma [2]. These circumstances lead to muscle compression and muscular ischemia, which will accelerate short-term alcohol myotoxicity.…”

Section: Resultsmentioning

confidence: 98%

“…These circumstances lead to muscle compression and muscular ischemia, which will accelerate short-term alcohol myotoxicity. In long-term alcohol abuse, RML develops because of electrolyte abnormalities, nutritional deprivation or peripheral neuropathy [2].…”

Section: Resultsmentioning

confidence: 99%

Elevated serum creatine kinase levels in psychiatric practice: differential diagnosis and clinical significance: A brief, practical guideline for clinicians

Voros

Osváth

Fekete

et al. 2008

International Journal of Psychiatry in Clinical Practice

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Introduction. Elevated serum CK levels often occur in psychiatric in-patient practice. Although the majority of cases are benign and temporary, it is important to recognize and treat these conditions. Aims. To discuss the etiology, the clinical significance and the management of elevated creatine kinase levels in psychiatric in-patient practice, focusing on antipsychotic-induced rhabdomyolysis. To compare the pathogenesis and the clinical features of rhabdomyolysis and neuroleptic malignant syndrome. Methods. Review of the literature. Results. A brief, practical guideline is introduced, which may help clinicians in the differential diagnosis and in the management of patients with elevated creatine kinase activity in emergent psychiatric practice. Conclusions. The most common etiologic factors (prescription drugs, alcohol, physical reasons, cardiac etiology) and clinical syndromes (rhabdomyolysis, neuroleptic malignant syndrome, acute coronary syndrome) should be considered, when elevated creatine kinase levels are encountered in psychiatric in-patients. Routine creatine kinase measurements in asymptomatic patients on antipsychotic medications are not recommended, but patients should be carefully followed for the development of rhabdomyolysis, when muscular symptoms arise. Careful monitoring of symptoms and potential complications is critical in order to avoid devastating clinical consequences. Cautiously challenging patients with another antipsychotic after an antipsychotic-induced rhabdomyolysis is recommended to decrease the possibility of recurrence.

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Nontraumatic Rhabdomyolysis with Long-Term Alcohol Intoxication

Cited by 21 publications

References 24 publications

Rhabdomyolysis in Community Acquired Bacterial Sepsis – A Retrospective Cohort Study

Rhabdomyolysis in Community Acquired Bacterial Sepsis – A Retrospective Cohort Study

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Elevated serum creatine kinase levels in psychiatric practice: differential diagnosis and clinical significance: A brief, practical guideline for clinicians

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