Nontuberculous mycobacteria in a tertiary Hospital in Portugal: A clinical review

Ruas, Rogério; Abreu, Ilda; Nuak, João; Ramos, Angélica; Carvalho, Teresa; Ribeiro, Mariana da Silva; Guimarães, João Tiago; Sarmento, António

doi:10.4103/ijmy.ijmy_177_17

Cited by 3 publications

(4 citation statements)

References 2 publications

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“…Colonization of M. genavense in the human body is common and almost always does not result in disease; however, a case of disseminated infection has recently been published in a previously healthy pet keeper, hypothesizing the zoonotic transmission probability [ 11 ]. As a widespread family, NTM could be isolated from various specimens due to colonization or specimen contamination [ 12 , 13 ]. M. genavense has been detected more frequently in HIV patients [ 5 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…As a widespread family, NTM could be isolated from various specimens due to colonization or specimen contamination [ 12 , 13 ]. M. genavense has been detected more frequently in HIV patients [ 5 , 12 ]. Despite this fact, multiple reports have discussed M. genavense infection in non-HIV immunodeficiencies, namely sarcoidosis, solid organ recipients, and primary immunodeficiencies [ 14 – 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Medication noncompliance might be a reason for this progression, and one reason is the high quantity of medications [ 30 , 31 ]. The NTM infection has a poor prognosis, with a mortality rate estimated at 32–39.3% among HIV patients [ 5 , 12 ], which illustrates the pathogen’s invasiveness and ineffective treatment methods. A recent systematic review of NTM CNS infections reported a 37.5% case fatality rate; although this review did not include any M. genavense cases [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Disseminated mycobacterium genavense infection with central nervous system involvement in an HIV patient: a case report and literature review

Hassanzadeh,

Hasannezhad,

Abbasian

et al. 2024

BMC Infect Dis

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Background Immunodeficient patients, particularly HIV patients, are at risk of opportunistic infections. Nontuberculous mycobacteria can cause severe complications in immunodeficient patients. Case Presentation We describe a 57-year-old HIV patient, primarily presented with coughs and constitutional symptoms, with a unique Mycobacterium genavense abdominal, pulmonary, and central nervous system infection, accompanied by intracranial masses. Conclusion The diagnosis of NTM, including M. genavense, must always be considered by clinicians in immunodeficient patients, especially those with HIV, who have a compromised immune system.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Disseminated mycobacterium genavense infection with central nervous system involvement in an HIV patient: a case report and literature review

Hassanzadeh,

Hasannezhad,

Abbasian

et al. 2024

BMC Infect Dis

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“…Since then M. paragordonae was only isolated twice, both from healthcare settings [35, 36]. The NTM species more frequently isolated from patients in Portugal in the last years were those in the M. avium complex, M. gordonae and M. kansasii [37]. Interestingly, our phylogenetic study shows that the three presumptive isolates initially identified as M. gordonae based on 16S rRNA sequencing [17], are in fact members of the recently described and rarely isolated species M. paragordonae , which raises questions about the true identity of clinical M. gordonae isolates, one of the species often recovered from patients in Portugal [37].…”

Section: Discussionmentioning

confidence: 99%

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

et al. 2019

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BackgroundNontuberculous mycobacteria (NTM) are ubiquitous in nature and recognized agents of opportunistic infection, which is often aggravated by their intrinsic resistance to antimicrobials, poorly defined therapeutic strategies and by the lack of new drugs. However, evaluation of their prevalence in anthropogenic environments and the associated antimicrobial resistance profiles have been neglected. In this work, we sought to determine minimal inhibitory concentrations of 25 antimicrobials against 5 NTM isolates recovered from a tertiary-care hospital surfaces. Antimicrobial susceptibilities of 5 other Corynebacterineae isolated from the same hospital were also determined for their potential clinical relevance.ResultsOur phylogenetic study with each of the NTM isolates confirm they belong to Mycobacterium obuense, Mycobacterium mucogenicum and Mycobacterium paragordonae species, the latter initially misidentified as strains of M. gordonae, a species frequently isolated from patients with NTM disease in Portugal. In contrast to other strains, the M. obuense and M. mucogenicum examined here were resistant to several of the CLSI-recommended drugs, suggestive of multidrug-resistant profiles. Surprisingly, M. obuense was susceptible to vancomycin. Their genomes were sequenced allowing detection of gene erm (erythromycin resistance methylase) in M. obuense, explaining its resistance to clarithromycin. Remarkably, and unlike other strains of the genus, the Corynebacterium isolates were highly resistant to penicillin, ciprofloxacin and linezolid.ConclusionsThis study highlights the importance of implementing effective measures to screen, accurately identify and control viable NTM and closely related bacteria in hospital settings. Our report on the occurrence of rare NTM species with antibiotic susceptibility profiles that are distinct from those of the corresponding Type strains, along with unexpected resistance mechanisms detected seem to suggest that resistance may be more common than previously thought and also a potential threat to frail and otherwise vulnerable inpatients.Electronic supplementary materialThe online version of this article (10.1186/s12866-019-1428-4) contains supplementary material, which is available to authorized users.

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Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases

Stout

Lange

Andréjak³

et al. 2022

The Lancet Infectious Diseases

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Nontuberculous mycobacteria in a tertiary Hospital in Portugal: A clinical review

Abstract: The present study highlights the importance of understanding the epidemiology of NTM to better comprehend their clinical impact.

Cited by 3 publications

References 2 publications

Disseminated mycobacterium genavense infection with central nervous system involvement in an HIV patient: a case report and literature review

Disseminated mycobacterium genavense infection with central nervous system involvement in an HIV patient: a case report and literature review

Studies of antimicrobial resistance in rare mycobacteria from a nosocomial environment

Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases

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