Nonwoven spidroin materials as scaffolds for <i>ex vivo</i> cultivation of aortic fragments and dorsal root ganglia

Mikhailova, Mariya M.; Sydoruk, Konstsntin V; Давыдова, Л. И.; Yastremsky, E. V.; Чвалун, С. Н.; Дебабов, В. Г.; Богуш, В. Г.; Panteleyev, Andrey

doi:10.1080/09205063.2022.2073426

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…In the repair process of peripheral nerve injury, SCs can down-regulate the expression of myelin-related genes and up-regulate the expression of growth-related genes, and further synthesize exogenous neurotrophic factors (NTFs), cell adhesion molecules NCAM and L1, and myelin-associated glycoprotein (MAG) to promote axonal regeneration and promote the myelination of regenerated axons [ [109] , [110] , [111] , [112] ]. However, it is difficult to obtain and culture SCs [ 113 ], so it is difficult to apply SCs in clinical practice.…”

Section: Adscs In Peripheral Nerve Injurymentioning

confidence: 99%

Adipose stem cells in tissue regeneration and repair: From bench to bedside

Dong,

Li,

Leng

et al. 2023

Regenerative Therapy

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Section: Adscs In Peripheral Nerve Injurymentioning

confidence: 99%

Adipose stem cells in tissue regeneration and repair: From bench to bedside

Dong,

Li,

Leng

et al. 2023

Regenerative Therapy

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“…Toxicological studies have revealed that hydrogels and microgels are harmless agents with neither irritating nor sensitizing action in animals [ 19 ]. In addition, numerous tests of 2D and 3D RSs-deriving products (rS1/9 and rS2/12; the latter one is a recombinant analogue of spidroin 2 in spider web scaffold filaments of Nephila madagascariensis ) in vitro and in vivo have demonstrated high levels of biocompatibility for all of them, as well as correlation between the rate of their bioresorption and the rate of new tissue formation [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Recombinant Spidroin Microgel as the Base of Cell-Engineered Constructs Mediates Liver Regeneration in Rats

et al. 2022

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Aim: In this study, we seek to check if recombinant spidroin rS1/9 is applicable for cell-engineering construct development. Novel technologies of cell and tissue engineering are relevant for chronic liver failure management. Liver regeneration may represent one of the possible treatment options if a cell-engineered construct (CEC) is used. Nowadays, one can see the continuous study of various matrices to create an appropriate CEC. Materials and Methods: We have adhered allogenic liver cells and multipotent mesenchymal bone marrow stem cells (MMSC BM) to a microgel with recombinant spidroin rS1/9. Then we have studied the developed implantable CEC in a rat model (n = 80) of chronic liver failure achieved by prolonged poisoning with carbon tetrachloride. Results: Our results demonstrate that the CECs change the values of biochemical tests and morphological parameters in chronic liver failure in rats. Conclusion: We consider there to be a positive effect from the microgel-based CECs with recombinant spidroin rS1/9 in the treatment of chronic liver failure.

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Harnessing the Potential of Spider Silk Proteins for Biomedical Applications: from Native Silk Fibers to Designed Bioactive Materials

Fang,

Li,

Kou

et al. 2024

Adv Funct Materials

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Spider silk has only been used anecdotally throughout human history, owing to limited supply from natural sources and recalcitrance toward biochemical functionalization. Recent advances in materials synthetic biology have ameliorated the challenges of mass‐producing spider silk and have thus paved the way for reengineering and redesigning these materials for real‐world applications. Here, an update is presented on the development of biomaterials comprising spider silk proteins within the past five years and the respective chemical and genetic approaches behind these developments. Potential applications are further highlighted in areas such as 3‐dimension (3D) cell culturing, drug delivery, theranostics, wound healing, tissue engineering, anti‐infection, and so on. By providing some glimpses into the latest innovations centered around spider silk proteins, as well as the challenges facing their biomedical applications, it is hoped that this will inspire more translational studies of these materials for real‐world impact.

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Nonwoven spidroin materials as scaffolds for ex vivo cultivation of aortic fragments and dorsal root ganglia

Cited by 5 publications

References 55 publications

Adipose stem cells in tissue regeneration and repair: From bench to bedside

Adipose stem cells in tissue regeneration and repair: From bench to bedside

Recombinant Spidroin Microgel as the Base of Cell-Engineered Constructs Mediates Liver Regeneration in Rats

Harnessing the Potential of Spider Silk Proteins for Biomedical Applications: from Native Silk Fibers to Designed Bioactive Materials

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