Noradrenaline-phospholipid interactions

Abstract

The uptake of (±)‐[3H]noradrenaline from an aqueous phase to an ether phase containing dissolved lecithin has been measured. No differences between the behaviour of (+)‐ or (—)‐noradrenaline in this system could be detected. The biological implications of this finding are discussed.

Relationships between Surface Activity and Biological Activity of Drugs

“…Veratrine, which increases membrane ionic permeability, in contrast, increased the rate of film desorption. Cuthbert (9) suggested that the K+ exchange and repetitive activity seen in nerves treated with veratrine alkaloids and the effect that these alkaloids have on monolayers probably have a common causation.…”

“…Cuthbert (9) suggested that the K+ exchange and repetitive activity seen in nerves treated with veratrine alkaloids and the effect that these alkaloids have on monolayers probably have a common causation. The latter drugs, which increase membrane permeability to Na+ and K+ in contrast to the effect of local anesthetics, reduced the area per molecule of a stearic acid monolayer (16).…”

A comparative study of the effect of bile salts on the absorption of quinalbarbitone sodium in goldfish

“…A number of workers have demonstrated an increased absorption in the presence of bile salts and other surfactants (Gibaldi & Nightingale, 1968;Anello & Levy, 1969;Nightingale & others, 1969;Florence & Gillan, 1975) and it is suggested that when an increase in permeability occurs then a specific effect on the lipid membrane is involved (Cuthbert, 1967). This action of bile salts would have been predicted since it has been reported that relatively small concentrations were capable of releasing lipid from erythrocyte ghosts (Kamat & Chapman, 1968) and Small, Penkett & Chapman (1969) found that bile salts converted the broad spectrum of lecithin in D,O to a high resolution nmr spectrum.…”

Non-ionic surfactants and membrane transport of thioridazine in goldfish

“…Nor was it clear by what mechanism those surfactants which increased transport across membranes did in fact exert this action. There is evidence that where permeability is increased a specific effect on the lipid membrane is involved (Cuthbert, 1967). It is likely that penetration of the non-ionic surface-active agent into the lipid layers of the membrane increases permeability, acting as it were like a plasticizer of the hydrocarbon lipid chains in the membrane interior.…”