Nordihydroguaiaretic acid reverses the antibacterial activity of colistin against MCR-1-positive bacteria in vivo/in vitro by inhibiting MCR-1 activity and injuring the bacterial cell membrane

Song, Ge; Zhou, Yonglin; Niu, Sen; Deng, Xuming; Qiu, Jiazhang; Li, Li

doi:10.1016/j.phymed.2022.153946

Cited by 13 publications

(3 citation statements)

References 28 publications

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“…Moreover, foodborne diseases are widely caused by Enterobacteriaceae, which is highly spread among various aquatic systems to be colonized in humans, causing urinary tract infections. In addition, the abuse of antibiotics in the aquatic environment has led to the emergence of new bacterial Enterobacter strains [35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Co-Infection as a Potential Threat to Farmed Flathead Grey Mullet (Mugil cephalus): Phenotypic and Molecular Diagnosis, Histopathology, Immunity Response, and In Vitro Antibacterial Evaluation

Elbahnaswy

Elshopakey

Shakweer

et al. 2023

Fishes

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Vibrio alginolyticus, Vibrio chlorea, and Enterococcus cloacae were the main bacterial pathogens investigated during recurrent episodes of mortalities among farmed flathead grey mullet (Mugil cephalus) in the Bahar El-Baqar area, Sharqia governorate, Egypt, during the summer season in 2021. Nevertheless, the contamination of water with heavy metals was evaluated. In this study, a total number of sixty moribund and freshly dead Mugil cephalus were examined clinically and upon post-mortem. Then, the bacterial isolates were subjected to bacteriological phenotypic examination, 16S rRNA gene sequencing, and antibiotic sensitivity testing. Histopathological screening and the immunity response of naturally infected M. cephalus were also implemented. In areas where bacterial strains were recovered in a high percentage, water contamination with Cu, Fe, and Ni was higher than the permissible limit. The results showed a high similarity (99–100%) to Vibrio and E. cloacae strains using phylogenetic analysis of 16S rRNA. Most isolates exhibited sensitivity to florfenicol, ciprofloxacin, and norfloxacin, while they were resistant to erythromycin and amoxicillin. Hemorrhage, oedema, hemosiderosis, and melanomacrophage activation in most affected tissues of infected M. cephalus were detected by light microscopy. Nevertheless, higher levels of AST and ALT, as well as serum inflammatory markers, CRP, and lysozyme activity, were shown in infected fish. There were higher MDA levels, along with a reduction of GSH, SOD, and catalase, in the gills and brain of infected M. cephalus, compared to the control fish. Our obtained data confirmed the high prevalence of Vibrio serovars and E. cloacae in infected grey mullets, describing their histopathological alterations, higher inflammatory response, and oxidative stress impact. These results could be useful indicators for understanding the pathogenesis of these pathogens in correlation with water parameter deterioration. Thus, the emergence of Vibrio and E. cloacae species in this study threatens the brackish water aquaculture industry in Egypt and poses a public health concern.

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Section: Introductionmentioning

confidence: 99%

Bacterial Co-Infection as a Potential Threat to Farmed Flathead Grey Mullet (Mugil cephalus): Phenotypic and Molecular Diagnosis, Histopathology, Immunity Response, and In Vitro Antibacterial Evaluation

Elbahnaswy

Elshopakey

Shakweer

et al. 2023

Fishes

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“…8,9 It is noteworthy that SPI-1deficient S. Typhimurium cannot cause systemic disease via oral transmission. 10,11 In recent years, as harmless sources of natural compounds have protective effects against infectious, malignant and inflammatory diseases, [12][13][14][15][16][17] a variety of medicinal plants have attracted considerable attention, while the underlying specific mechanisms remain largely undetermined. In our current work, we found that hyperoside (HYP) inhibited S. Typhimurium invasion into host cells.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, as harmless sources of natural compounds have protective effects against infectious, malignant and inflammatory diseases, 12–17 a variety of medicinal plants have attracted considerable attention, while the underlying specific mechanisms remain largely undetermined. In our current work, we found that hyperoside (HYP) inhibited S .…”

Section: Introductionmentioning

confidence: 99%

A natural compound hyperoside targetsSalmonellaTyphimurium T3SS needle protein InvG

et al. 2022

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Laurocapram, a transdermal enhancer, boosts cephalosporin’s antibacterial activity against Methicillin-resistant Staphylococcus aureus

Wang,

Li,

et al. 2024

Biochemical Pharmacology

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Nordihydroguaiaretic acid reverses the antibacterial activity of colistin against MCR-1-positive bacteria in vivo/in vitro by inhibiting MCR-1 activity and injuring the bacterial cell membrane

Cited by 13 publications

References 28 publications

Bacterial Co-Infection as a Potential Threat to Farmed Flathead Grey Mullet (Mugil cephalus): Phenotypic and Molecular Diagnosis, Histopathology, Immunity Response, and In Vitro Antibacterial Evaluation

Bacterial Co-Infection as a Potential Threat to Farmed Flathead Grey Mullet (Mugil cephalus): Phenotypic and Molecular Diagnosis, Histopathology, Immunity Response, and In Vitro Antibacterial Evaluation

A natural compound hyperoside targetsSalmonellaTyphimurium T3SS needle protein InvG

Laurocapram, a transdermal enhancer, boosts cephalosporin’s antibacterial activity against Methicillin-resistant Staphylococcus aureus

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