2016
DOI: 10.1155/2016/5027404
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Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruziActivity

Abstract: Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar conductivity, and elemental analyses. The experimental data suggest that norfloxacin was coordinated to copper(II) through the carboxylato and ketone oxygen atoms. The interaction of the copper(II) complexes with bovine serum albumin (BSA) and human serum albumin (HS… Show more

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Cited by 29 publications
(18 citation statements)
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“…Indirect methods of fluorescence quenching are used, for the most part, to study metal complexes with albumins. The most widespread complexing metals whose binding is studied with these methods are Co [8,39,42,43,50] and Cu [44][45][46]51,131,141] the most widespread DNA-binding complexing metal is Cu. [44][45][46][47]49,141] As far as the constants are concerned, pK of the Stern-Volmer quenching constants are equal on the average to 5.…”
Section: Discussionmentioning
confidence: 99%
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“…Indirect methods of fluorescence quenching are used, for the most part, to study metal complexes with albumins. The most widespread complexing metals whose binding is studied with these methods are Co [8,39,42,43,50] and Cu [44][45][46]51,131,141] the most widespread DNA-binding complexing metal is Cu. [44][45][46][47]49,141] As far as the constants are concerned, pK of the Stern-Volmer quenching constants are equal on the average to 5.…”
Section: Discussionmentioning
confidence: 99%
“…X-ray crystallography [23, 24, 40-48, 50, 136-138, 140-142, 145, 150, 151, 156-214] IR-spectroscopy [37, 41, 51, 54, 137, 140, 142, 145, 148, 149, 156, 158-161, 166-170, 172-174, 178, 179, 181, 182, 184-186, 188, 189, 191-198, 200, 202, 204, 205, 207-210, 215-233] Circular dichroism spectroscopy [8, 33-35, 39, 40, 142, 141, 143, 145-149, 163, 168, 169, 172, 179, 185, 189, 193, 196, 199, 202, 203, 206, 216, 219, 221, 223, 225, 226, 229, 231-239] EPR-spectroscopy [49,51,54,159,167,181,187,197,200,201,209,215,216,219,222,223,240] NMR-spectroscopy [37, 41, 52, 140, 142, 149, 155, 158, 161, 172, 179, 181, 183, 185, 188, 191, 192, 200, 202, 204, 205, 207, 209, 210, 214, 218-221, 223, 225, 227, 229-232, 236, 238, 241-243] Cyclic voltammetry [42-46, 48, 50, 54, 149, 151, 159, 164, 167, 173, 175, 176, 179, 184, 189, 208, 211-213, 221, 230, 240, 241, 244-247] X-ray crystallography, as a rule, is used for corroboration or specification of the structure of coordinated metal complexes themselves, [24,40,42] in particular, new biologically active compounds or earlier unknown coordination structures. [7,41,43,44,248] X-ray photoelectron spectroscopy for C, N, and O is used to obtain the information of the changes in the energy of atom bonds of these elements in the protein during the formation .…”
Section: Methods Sourcementioning
confidence: 99%
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