Normal complement in early poststreptococcal glomerulonephritis.

McLean, Robert H.; Schrager, Mark A.; Rothfield, Naomi F.; Berman, Monique A.

doi:10.1136/bmj.1.6072.1326

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…[21][22][23] Serum C3 concentrations in affected patients are often < 20% of the concentration for clinically normal humans. 20,24 Despite the essential role that complement plays in the host defense mechanism, the ability to quantify specific components of complement in canine serum is not readily available. The authors are aware of only 1 study 5 in which complement concentrations were evaluated in dogs with PLN.…”

Section: C3mentioning

confidence: 99%

Serum concentrations of the third component of complement in healthy dogs and dogs with protein-losing nephropathy

Acierno

Labato²,

Stern³

et al. 2006

ajvr

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C3 is a critical part of the immune defense system that has not been extensively examined in veterinary medicine. An ELISA was developed for measuring C3 concentrations, and a reference range for healthy dogs was established. Significant decreases in C3 concentrations were not detected in any dog with PLN. Additional studies will be required to definitively determine the importance of serum C3 concentrations in PLN.

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Section: C3mentioning

confidence: 99%

Serum concentrations of the third component of complement in healthy dogs and dogs with protein-losing nephropathy

Acierno

Labato²,

Stern³

et al. 2006

ajvr

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“…Uno de ellos (caso 8) tuvo 2 biopsias sucesivas con 15 di'as de intervalo, por resultar la primera satisfactoria solo para la IN, observandose que el C 3 en inmunofluorescencia bajo de +++ a + en dicho periodo, variation que parece reforzar la necesidad de biopsia precoz para observar los hechos mas caracterfsticos de la histopatologia en esta enfermedad 35 . Los 12 ninos en que la normalization del complemento C 3 fue mas rapida, antes de los 14 dias, destacan tambien la importancia de solicitor estc examen muy precozmente si se quiere observar la hipocomplementemia.…”

Section: Comentariosunclassified

La glomerulonefritis aguda en el niño: Estudio prospectivo de aspectos clinicos, histopatologicos e inmunologicos

U¹,

L²,

G³

et al. 1987

Rev. chil. pediatr.

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Acute glomerular nephritis in childrenForty live ehildren (23 boys) 22to 15 years old (mean age 7.7 years) with clinical and histological evidence of acute glomerular nephritis (AGN) were followed by 30 months. A.II patients were studied with percutaneous renal biopsies in tlic first month after the begining of the disease (mean 20 days) and in 31 patients, a second renal biopsy was done: in 12 at x 194 days (range 171 to" 212 days) and in 19 at x 590 days (range 418 to 999 days). With only 5 exceptions (11.1%) all patients recalled clinical evidence of antecedent cutaneous (37.8%), respiratory (51.1%) or combined cutaneous and respiratory infections (11.1%) but group A bctha hcmolitycus estrep toco ecus (GABHE) was only isolated from six patients, probably because of previous antibiotic treatment. Edema and hypertension dissapearcd in a mean of 8.8 and 4.3 days respectively. Haematuria was present in only 44%of the patients in the first urine examination, protemuria in 51% and eilindruria in 29.9% of the cases, but at last, hematuria was demonstrated in 41 /45 patients; proteinuria, that was present in a!3 cases without hematuria, finally ocurred in 95% of all the affected children and eilindruria was detected in 64%of the total series. A good correlation was found in the histologic study between the magnitude of the lesions at optic and electronic microscopy. In the first biopsy all patients showed segmental intramembranous, inrnune deposits. In the second series of renal biopsies the intensity of the lesions was, clearly, lesser at six months and the microscopical findings were already normal in three cases at 590 days.

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A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience

2012

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Juvenile acute non-proliferative glomerulonephritis (JANG) is a relatively new clinico-pathological entity established in 2000. A PubMed search revealed only two published reports encompassing 14 cases of JANG. It is distinguished from acute post-streptococcal glomerulonephritis by the presence of normal serum complement and the absence of diffuse proliferation of mesangial cells in the glomeruli. We report a case of a 4-year-old child that presented with a clinical scenario and renal biopsy findings consistent with JANG. She responded well to treatment with high-dose methylprednisolone for 3 days, followed by gradual taper with oral prednisone. She was monitored closely for a period of 6 years and continues to do well with normal renal parameters and without any medications.

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Normal complement in early poststreptococcal glomerulonephritis.

Cited by 6 publications

References 2 publications

Serum concentrations of the third component of complement in healthy dogs and dogs with protein-losing nephropathy

Serum concentrations of the third component of complement in healthy dogs and dogs with protein-losing nephropathy

La glomerulonefritis aguda en el niño: Estudio prospectivo de aspectos clinicos, histopatologicos e inmunologicos

A rare case of juvenile acute non-proliferative glomerulonephritis with a 6-year follow-up experience

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