Normal Feline Brain: Clinical Anatomy Using Magnetic Resonance Imaging

Mogicato, Giovanni; Conchou, Fabrice; Layssol‐Lamour, Catherine; Raharison, F.; Sautet, J.

doi:10.1111/j.1439-0264.2011.01106.x

Cited by 18 publications

(22 citation statements)

References 12 publications

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“…Surface gyri and sulci are easily distinguished on all images as well as deeper structures within the frontal cortex, internal capsule, caudate, striatum, thalamus, midbrain, cerebellum and brainstem. Several areas previously reported to be unresolvable on MRI, such as the dentate, interpositus and fastigial cerebellar nuclei and vestibular nuclei (Mogicato et al, 2012), are clearly identified (Figures 1c, 2 and 3). The visual pathway is apparent starting from the optic nerve through the chiasm and tract to the lateral geniculate nucleus and optic radiation (Figure 1b, 2, 3).…”

Section: Resultsmentioning

confidence: 81%

“…Anatomic structures were identified using a previously published MRI-based atlas (Mogicato et al, 2012) and the feline (Bleier et al, 1961, Snider et al, 1970) and canine (Singer et al, 1962, Buxton et al, 1986) histologic atlases. Anatomical structure nomenclature follows the format of the Illustrated Veterinary Anatomical Nomenclature (Schaller et al, 2007) and Nomina Anatomica Verterinaria (I.C.V.G.A.N.…”

Section: Methodsmentioning

confidence: 99%

“…As these therapies approach human clinical trials, in-depth analysis of changes within specific brain structures will be vital for understanding effects of therapy. Currently, the feline brain MRI anatomy is available at reduced resolution from lower field-strength MRI (1.5 Tesla) (Mogicato et al, 2012), but advances in MRI technology have led to high-field strength MRI in neurologic disease research. MRI at ~3 Tesla (3T) is the highest field strength currently approved by the Food and Drug Administration (FDA) for human patients and images collected at this field strength provide pronounced improvements in image clarity and detail in feline models.…”

Section: Introductionmentioning

confidence: 99%

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High resolution MRI anatomy of the cat brain at 3Tesla

Gray‐Edwards¹,

Salibi²,

Josephson³

et al. 2014

Journal of Neuroscience Methods

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Background Feline models of neurologic diseases, such as lysosomal storage diseases, leukodystrophies, Parkinson’s disease, stroke and NeuroAIDS, accurately recreate many aspects of human disease allowing for comparative study of neuropathology and the testing of novel therapeutics. Here we describe in vivo visualization of fine structures within the feline brain that were previously only visible post mortem. New Method 3 Tesla MR images were acquired using T1-weighted (T1w) 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence (0.4mm isotropic resolution) and T2-weighted (T2w) turbo spin echo (TSE) images (0.3×0.3×1 mm3 resolution). Anatomic structures were identified based on feline and canine histology. Results T2w high resolution MR images with detailed structural identification are provided in transverse, sagittal and dorsal planes. T1w MR images are provided electronically in three dimensions for unrestricted spatial evaluation. Comparison with Existing Methods Many areas of the feline brain previously unresolvable on MRI are clearly visible in three orientations, including the dentate, interpositus and fastigial cerebellar nuclei, cranial nerves, lateral geniculate nucleus, optic radiation, cochlea, caudal colliculus, temporal lobe, precuneus, spinocerebellar tract, vestibular nuclei, reticular formation, pyramids and rostral and middle cerebral arteries. Additionally, the feline brain is represented in 3 dimensions for the first time. Conclusions These data establish normal appearance of detailed anatomical structures of the feline brain, which provide reference when evaluating neurologic disease or testing efficacy of novel therapeutics in animal models.

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Section: Resultsmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High resolution MRI anatomy of the cat brain at 3Tesla

Gray‐Edwards¹,

Salibi²,

Josephson³

et al. 2014

Journal of Neuroscience Methods

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“…Recently, Mogicato et al. () provided a clinical anatomy atlas of the feline brain using 1.5 T magnetic resonance unit. They showed that most relevant brain structures can be identified by MRI.…”

Section: Discussionmentioning

confidence: 99%

Gyration of the Feline Brain: Localization, Terminology and Variability

Pakozdy

Angerer

Klang

et al. 2014

Anat Histol Embryol

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The terminology of feline brain gyration is not consistent and individual variability has not been systematically examined. The aim of the study was to identify the gyri and sulci of cat brains and describe them using the current terminology. The brains of 15 cats including 10 European shorthairs, 2 Siamese, 2 Maine coons and one Norvegian forest cat without clinical evidence of brain disease were examined post-mortem and photographed for documentation. For description, the terms of the most recent Nomina Anatomica Veterinaria (NAV, 2012) were used, and comparisons with previous anatomical texts were also performed. In addition to the lack of comparative morphology in the NAV, veterinary and human nomenclature are used interchangeably and inconsistently in the literature. This presents a challenge for neurologists and anatomists in localizing gyri and sulci. A comparative analysis of brain gyration showed only minor individual variability among the cats. High-quality labelled figures are provided to facilitate the identification of cat brain gyration. Our work consolidates the current and more consistent gyration terminology for reporting the localization of a cortical lesion based on magnetic resonance imaging or histopathology. This will facilitate not only morphological but also functional research using accurate anatomical reporting.

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“…Entretanto os exames imagológicos podem também ser considerados instrumentos facilitadores do processo de ensino-aprendizagem na neuroanatomia. Assim é possível que as imagens derivadas dessas técnicas de diagnóstico sejam utilizadas para reconstrução 3D, frequentemente aplicadas no ensino atual de anatomia (KRAFT et al, 1989;CHAFFIN et al, 1997;ARENCIBIA et al, 2001;LEIGH et al, 2008;MOGICATO et al, 2012;GRAY-EDWARDS et al, 2014;RAFFAN et al, 2017;STEPAN et al, 2017).…”

Section: Revisão De Literaturaunclassified

>b<Elaboração de uma ferramenta de ensino-aprendizagem multidisciplinar de neuroanatomia do equino (>i<Equus caballus>/i<, Linneaus, 1758)>/b<

Cereta¹

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Among the topics of Animal Anatomy, neuroanatomy is presented as one of the most complex contents, in which traditional teaching methods don't allow students to have effective comprehension, and implies the need for complementary approaches to optimize their learning. This work aimed at the development of a teaching & learning tool for the study of neuroanatomy, using a collection of cross-sectional slides of the Central Nervous System (CNS) of the horse. Cross-sectional slides already prepared, stained with the modified Pal-Weigert staining technique, were used to identify neuroanatomic structures and to associate neuroanatomy with neurological syndromes of this species. In addition to this, schematic illustrations were performed to indicate the sites affected by neurological disorders and to represent the cross-sectional sections of the horse. A website prototype was also developed to exemplify the use of educational technologies, such as the use of softwares and computers as facilitators for the understanding of neuroanatomic structures and their clinical relationships. The use of the cross sectional slides of the CNS of the horse allowed the identification of anatomical structures, dividing their totality into sequential intervals to demonstrate the comprehensiveness and topography of CNS structures, as well as supporting the relationship between neuroanatomy and neurological syndromes. Furthermore, it was possible to maintain and preserve the collection of CNS sectional slides from the Laboratory of Comparative Neuroanatomy of the Department of Surgery of the Faculty of Veterinary Medicine and Animal Science of the University of São Paulo. Through this study we seek to broaden the discussions about the use of traditional techniques of study in animal anatomy, alliedto new educational technologies and complementary teaching methods, once teaching and learning tools can be developed aiming at undergraduate teaching, at a distance or faceto-face, or even through continuing education.

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Normal Feline Brain: Clinical Anatomy Using Magnetic Resonance Imaging

Cited by 18 publications

References 12 publications

High resolution MRI anatomy of the cat brain at 3Tesla

High resolution MRI anatomy of the cat brain at 3Tesla

Gyration of the Feline Brain: Localization, Terminology and Variability

>b<Elaboração de uma ferramenta de ensino-aprendizagem multidisciplinar de neuroanatomia do equino (>i<Equus caballus>/i<, Linneaus, 1758)>/b<

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