Normal Growth and Pubertal Development During Bromocriptine Therapy in Two Patients with Prolactinoma.

Kamel, Nurí; Uysal, Ali Rıza; Cesur, Vedia; Erdoan, Gürbüz; Baskal, Nilcün

doi:10.1507/endocrj.42.581

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…While it may cause hypogonadism, loss of libido, infertility, erectile dysfunction, and gynecomastia in adult males, [13,14] also it can rarely cause delayed puberty, pubertal arrest, or short stature in children and adolescents. [6] The case presented here had the initial symptoms of short stature and pubertal arrest. The main cause of hyperprolactinemia-related hypogonadism is gonadotropin releasing hormone (GnRH) inhibition.…”

Section: Discussionmentioning

confidence: 84%

“…[5] Hyperprolactinemia may cause impotence and hypogonadism in adult men, and rarely leads to pubertal arrest and delayed puberty among adolescents. [6] In this report, we present a case with a giant prolactinoma admitted to our clinic with the symptom of pubertal arrest that disappeared in a short time with dopamine agonist therapy primarily.…”

Section: Introductionmentioning

confidence: 99%

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Giant pubertal prolactinoma: Complete resolution following short term carbegoline treatment

et al. 2016

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Prolactinomas are the most common pituitary tumors but rarely seen in adolescent males. There is no indication for surgery both in micro- and macro-adenomas unless an urgent treatment is necessary. First line treatment is always medical with dopamine agonists. In this report, we presented a patient with pubertal arrest and giant prolactinoma that disappeared in a short time with cabergoline treatment.

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Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Giant pubertal prolactinoma: Complete resolution following short term carbegoline treatment

et al. 2016

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“…Bromocriptine, first introduced in the late 1970s, is considered to be the therapy of first choice for prolactin-secreting pituitary adenomas /4,12,14,18-19,36-38/. Good responses to bromocriptine have been documented in several large adult series, but there have been few reports of the response in children /4-9, [11][12]14,[24][25][26][27][28][29][30][31][32][33]36/. In the past 25 years, only five cases of prolactin-secreting pituitary adenoma and one case of idiopathic hyperprolactinaemia have been diagnosed at the Royal Children's Hospital, Melbourne, which is the main paediatric referral centre for a population of four million people.…”

Section: Introductionmentioning

confidence: 99%

Hyperprolactinaemia and Pituitary Adenomas in Adolescence

Dissaneevate

Warne²

1998

Journal of Pediatric Endocrinology and Metabolism

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Six adolescents, Ave males with prolactinsecreting pituitary macroadenomas and one female with idiopathic hyperprolactinaemia, are described. Their ages at presentation ranged from 13 years 7 months to 16 years 6 months. Presenting symptoms included headache, visual field defect, arrested growth and puberty. Only two cases had galactorrhoea. Every case had an elevated serum prolactin level. Three had surgery before the results of serum prolactin were to hand. Each patient was treated with bromocriptine. Bromocriptine suppressed serum prolactin level to normal in four cases, but in the girl with idiopathic hyperprolactinaemia, bromocriptine was not useful. In two boys, serum prolactin was not suppressed with bromocriptine therapy alone, and they were subsequently treated with cabergoline, surgery and irradiation. Nevertheless, in children and adolescents with prolactin-secreting pituitary adenoma, bromocriptine should be the first line of treatment.

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“…Muchos tratamientos se han utilizado a lo largo de la historia. Se han empleado múltiples agonistas de la dopamina tratando siempre de minimizar sus efectos secundarios 4,10,23 ; diferentes modalidades de terapia radiante que van desde la clásica cobaltoterapia externa, hasta la radiocirugía estereotáxica en cualquiera de sus variantes 14,19 y el abordaje quirúrgico que ha evolucionado desde finales del siglo X1X 3,9,12,16 . Así, la elección del tratamiento debe individualizarse y muchas veces se utiliza la terapia combinada.…”

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