Normal mesenteric lymph ameliorates acute kidney injury following lipopolysaccharide challenge in mice

Protective effects of different Bacteroides vulgatus strains against lipopolysaccharide-induced acute intestinal injury, and their underlying functional genes

“…A series of previous studied have shown that MLNs-resident immune cells (such as Treg cells and dendritic cells) have an important role in immune tolerance [52] . Normal mesenteric lymph ameliorated LPS-induced acute kidney injury in mice [53] , suggesting that MLNs plays a potential role in regulating LPS-induced inflammation. A similar result can be found in another study which showed that NML treatment could help reduce LPS-induced urea, CD14, TNF-α, and IL-6 levels in mice [53] .…”

“…Normal mesenteric lymph ameliorated LPS-induced acute kidney injury in mice [53] , suggesting that MLNs plays a potential role in regulating LPS-induced inflammation. A similar result can be found in another study which showed that NML treatment could help reduce LPS-induced urea, CD14, TNF-α, and IL-6 levels in mice [53] . Besides, the results of histological evaluation showed that B. vulgatus FTJS7K1, but not other B. vulgatus strains supplementation, could inhibit LPS-induced proinflammatory cytokines secretion and lower the DAI scores significantly.…”

Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury

“…In previous studies, the exogenous normal mesenteric lymph (NML) from healthy dog has alleviating effects on LPS-induced microcirculation disturbance and acute lung and kidney injury in rats [6][7][8] . In addition, NML obtained from mice could ameliorate acute kidney injury induced by the LPS challenge, and such effect is related to decreasing inflammation and LPS sensitization 9 .…”