Normal muscle structure, growth, development, and regeneration

Pinto, Wladimir Bocca Vieira de Rezende; Souza, Paulo Victor Sgobbi de; Oliveira, Acary Souza Bullé

doi:10.1007/s12178-015-9267-x

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…These smaller, immature fibers, while capable of signal transduction, contribute less to the contractility of the overall muscle, and by extension, to a lower summation of action potentials forming the basis of the CMAP 28 . Nevertheless, it is noteworthy that all recorded CMAPs were in the millivolt range, resulting in signals that are at least 80 times greater than similar recordings performed with electrodes placed directly on peripheral nerves 6 .…”

Section: Discussionmentioning

confidence: 87%

Regenerative peripheral nerve interface free muscle graft mass and function

Ursu

Sohasky

et al. 2020

Muscle and Nerve

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Background Regenerative peripheral nerve interfaces (RPNIs) transduce neural signals to provide high‐fidelity control of neuroprosthetic devices. Traditionally, rat RPNIs are constructed with ~150 mg of free skeletal muscle grafts. It is unknown whether larger free muscle grafts allow RPNIs to transduce greater signal. Methods RPNIs were constructed by securing skeletal muscle grafts of various masses (150, 300, 600, or 1200 mg) to the divided peroneal nerve. In the control group, the peroneal nerve was transected without repair. Endpoint assessments were conducted 3 mo postoperatively. Results Compound muscle action potentials (CMAPs), maximum tetanic isometric force, and specific muscle force were significantly higher for both the 150 and 300 mg RPNI groups compared to the 600 and 1200 mg RPNIs. Larger RPNI muscle groups contained central areas lacking regenerated muscle fibers. Conclusions Electrical signaling and tissue viability are optimal in smaller as opposed to larger RPNI constructs in a rat model.

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Section: Discussionmentioning

confidence: 87%

Regenerative peripheral nerve interface free muscle graft mass and function

Ursu

Sohasky

et al. 2020

Muscle and Nerve

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“…Several pathologies of skeletal muscle, including severe congenital myopathies such as nemaline myopathy, are characterized by sarcomeric disarray caused by abnormalities in actin regulation (de Rezende Pinto et al, 2015;Romero et al, 2013). Interestingly, unlike the genetic deletion of MRTF/SRF targets, such as LMOD3, loss of MRTFs in skeletal muscle did not cause nemaline myopathy.…”

Section: Discussionmentioning

confidence: 98%

Myocardin-related transcription factors are required for skeletal muscle development

et al. 2016

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Myocardin-related transcription factors (MRTFs) play a central role in the regulation of actin expression and cytoskeletal dynamics. Stimuli that promote actin polymerization allow for shuttling of MRTFs to the nucleus where they activate serum response factor (SRF), a regulator of actin and other cytoskeletal protein genes. SRF is an essential regulator of skeletal muscle differentiation and numerous components of the muscle sarcomere, but the potential involvement of MRTFs in skeletal muscle development has not been examined. We explored the role of MRTFs in muscle development in vivo by generating mutant mice harboring a skeletal muscle-specific deletion of MRTF-B and a global deletion of MRTF-A. These double knockout (dKO) mice were able to form sarcomeres during embryogenesis. However, the sarcomeres were abnormally small and disorganized, causing skeletal muscle hypoplasia and perinatal lethality. Transcriptome analysis demonstrated dramatic dysregulation of actin genes in MRTF dKO mice, highlighting the importance of MRTFs in actin cycling and myofibrillogenesis. MRTFs were also shown to be necessary for the survival of skeletal myoblasts and for the efficient formation of intact myotubes. Our findings reveal a central role for MRTFs in sarcomere formation during skeletal muscle development and point to the potential involvement of these transcriptional co-activators in skeletal myopathies.

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“…The average speed of protein synthesis from basal fractional muscle, tendon, bone, cartilage, ligament and menisci ranges between 0.02 and 0.13% per hour in vivo in humans [29]. The portion of myofibrillar protein represents up to 85% of muscle fiber volume [30,31].…”

Section: Resultsmentioning

confidence: 99%

Role of Healthy Food Daily Consumption on the Forming of the Breasts, Thighs, Buttocks for Getting Healthy, Sexy and Interesting Body

Lelyana¹

2020

Act Sci wom hea

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Introduction Introduction: A person's body shape is influenced by various factors. Many women who want a healthy body shape, sexy and attractive. One of the parameters of a woman's attractiveness is the shape and size of her breasts, thighs and buttocks. Unclear understanding the ways to get a healthy, beautiful and attractive body shape because of many factors that influence it. One of many factors is the food factor, but it is still unknown how food affects the formation of breasts, thighs and buttocks. Therefore, this paper aims to discuss the role of food in the formation of breasts, thighs and buttocks in women so that they look healthy, sexy and attractive. Methods: Systematic Review. Results: Consumption of healthy foods consists of carbohydrates, proteins, fats, vitamins, minerals and water. Consumption of healthy foods affects of someone body shape. Consumption of dairy food, yogurt, spicy favor, eggs, chicken breast, beef, flax seeds, whey protein, fatty fish, beans, legumes, soybeans, vegetables, vitamins and minerals will influence the formation of fat cells and muscle cells. In fact, exercise helps food activity in influencing the formation of cells and organs of the body. Discussion: The breasts, thighs and buttocks are mostly composed of fat and supporting muscle tissue around the area of the organ. Body fat tissue is obtained from food consumption. Excessive consumption of food that is not used by the body will be stored as adipose tissue. Muscle tissue is formed from the consumption of various foods, especially those containing protein. Consumption of healthy food affects the formation of body cells or body cells forming naturally. Conclusion: Consumption of healthy foods will affect the formation of body cells such as fat cells and muscle cells so that they will form healthy, sexy and attractive breasts, buttocks and thighs.

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Normal muscle structure, growth, development, and regeneration

Cited by 18 publications

References 35 publications

Regenerative peripheral nerve interface free muscle graft mass and function

Regenerative peripheral nerve interface free muscle graft mass and function

Myocardin-related transcription factors are required for skeletal muscle development

Role of Healthy Food Daily Consumption on the Forming of the Breasts, Thighs, Buttocks for Getting Healthy, Sexy and Interesting Body

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