Normal pancreatic and intestinal enzymes in hypophagic growth-retarded rats that received dorsomedial hypothalamic lesions shortly after weaning

Bernardis, Lee L.; Lee, Ping C.; Brooks, Stephen; Lebenthal, Emanuel

doi:10.1016/0091-3057(84)90222-3

Cited by 5 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rats, as in humans, the digestive enzymes of the small intestine are immature and undergo rapid development postnatally (6)(7)(8)(9)(10)14). Characteristically, lactase is high in neonates and decreases rapidly at weaning to reach a much lower adult level.…”

Section: Discussionmentioning

confidence: 99%

“…Upon release from hypoxia, the hormonal effect dissipates and the enzymes return to their original levels. From 14 to 21 days of age, the small intestine undergoes rapid transformation (6)(7)(8)(9)(10). Prior hypoxic condition then manifested its effects by upsetting the genetic programming and the timing of differentiation of mucosal cells thus leading to a delayed appearance of mucosal enzymes in the 21-day-old animals (14 days posthypoxic).…”

Section: Bodymentioning

confidence: 99%

“…Similar effects of hypoxia may also occur in the small intestine. In neonatal rats, as in human infants, the intestine undergoes rapid differentiation and maturation of its digestive enzymes (6)(7)(8)(9)(10), Neonates have high lactase, undetectable sucrase, and low maltase activity. In rodents, sucrase and maltase activity increase rapidly around the 15th day of age.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of Hypoxia on the Development of Intestinal Enzymes in Neonatal and Juvenile Rats

Lee¹,

Struve²,

Raff

2003

Exp Biol Med (Maywood)

Self Cite

View full text Add to dashboard Cite

Hypoxia in the neonate is known to alter the activity of hepatic and pancreatic enzymes involved in lipid and carbohydrate metabolism. The purpose of this study was to evaluate the effect of neonatal hypoxia on the activity of intestinal enzymes, and to determine whether the administration of glucocorticoids to neonates can mimic the effects of hypoxia. Hypoxia in neonatal rats (0-7 days) increased protein content, and lactase and maltase activity in the duodenal and the jejunal segments of the small intestine compared with normoxic controls. Hypoxia in juvenile rats (28-35 days) did not change these enzymes. Two weeks after returning hypoxic (0-7 days) pups to normoxia, their body weight remained lower than the age-matched controls. In the group recovering from hypoxia, sucrase, maltase, and leucine aminopeptidase activities were lower in the duodenal and the jejunal segment. Compared with controls, LDH activity was lower only in the jejunal intestine in the group recovering from hypoxia. All enzyme activities returned to control levels 3 weeks after recovery. Neonatal rats treated with dexamethasone had a decrease in body weight, but increases in sucrase and maltase activity in both the duodenal and the jejunal segment. Hypoxia in newborn rats caused a delayed maturation of small intestinal enzymes. Increases in serum glucocorticoids after hypoxic exposure probably do not play a major role in the delayed maturation of the disaccharidase activity in the small intestine.

show abstract