Normal range of white blood cells and differential count of Sudanese in Khartoum state

Taha, Elmutaz H.; Elshiekh, Mohammed; Alborai, Abdelrahim; Hajo, Elnagi Y.; Hussein, Abdelmohisen; Awad, Kamal; Ali, Ibrahim; Musa, Omer A

doi:10.18203/2349-3933.ijam20183116

Cited by 7 publications

(9 citation statements)

References 18 publications

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“…The results of our study demonstrated significantly lower white cell and neutrophil counts in Africans, with neutrophil counts being as low as 1.05 × 10 9 /L. These results support others who have reported similar results in healthy African individuals . A recent study, also forming part of the C‐RIDL project and carried out on healthy urban Kenyans, proposed a neutrophil reference interval of 1.05‐4.08 × 10 9 /L which is very similar to the values observed in the black African population of this current study .…”

Section: Discussionsupporting

confidence: 91%

“…These results support others who have reported similar results in healthy African individuals. 4,5,8,14,15 A recent study, also forming part of the C-RIDL project and carried out on healthy urban Kenyans, proposed a neutrophil reference interval of 1.05-4.08 × 10 9 /L which is very similar to the values observed in the black African population of this current study. 16 These reports have all proposed separate reference ranges for Africans, which is important, as they could influence clinical decision-making, especially in the field of oncology and the initiation of chemotherapy.…”

Section: Ta B L E 1 Population Characteristicssupporting

confidence: 81%

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Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa

Smit

Davison

Hoffmann

et al. 2019

Int J Lab Hematology

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Background Research has suggested that individuals of African descent have lower white cell and neutrophil counts than Caucasians. These differences could lead to incorrect clinical decisions, and therefore, ethnic‐specific reference ranges are required. The Western Cape region of South Africa is uniquely diverse, comprising Caucasian, Mixed Ancestry and those of African descent. The aim of this study was to compare the full blood count and differential counts across the three major ethnic groups residing in this area and to propose appropriate RIs. Methods The study formed part of the international project led by the Committee on Reference Intervals and Decision Limits (C‐RIDL), and therefore, the strict guidelines laid out by the committee were followed. Full blood count and differential counts were performed on a Beckman Coulter ACT 5 diff AL analyser within 2‐4 hours of collection and were reported as mean (standard deviation), 2.5th and 97.5th percentiles. Comparisons were analysed using Spss v25 and Statistica v13, and a P value of < 0.05 was considered significant. Results Reference ranges for Caucasian and Mixed Ancestry individuals were similar while white cell (P = 0.016), monocyte (P < 0.001), neutrophil (P = 0.034) and red cell indices were significantly different amongst the three population groups. There were however no statistical and clinical significant differences between the eosinophil, lymphocyte, red cell and platelet counts across the three groups. Conclusion In conclusion, subjects of Mixed Ancestry, in this region, have similar reference intervals to those of European descent, while lower white cell and neutrophil counts in Africans have been confirmed.

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Section: Discussionsupporting

confidence: 91%

Section: Ta B L E 1 Population Characteristicssupporting

confidence: 81%

Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa

Smit

Davison

Hoffmann

et al. 2019

Int J Lab Hematology

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“…Our study was showed that the mean TWBCs at morning is significantly different than in evening and there is significant increase in TWBCs at evening. More recent study linked the TWBCs to obesity, in recent ongoing study on normal hematological study in Sudanese population it had been observed that the WBCs was found to be more in obese subjects, as exercise is known to increase the WBC count physiologically it has been suggested that the normal daily movement for obese subject could be take an increase for them [3].…”

Section: Discussionmentioning

confidence: 99%

“…The WBCs count of Sudanese people was found to be lower than that of Caucasians and similar to reports from other African countries; Taha, et al performed a study and they found the mean of WBC count was 5.1±1.5×103/ μl with a range of 3.6 ×103/μl to 6.6 ×103/μl. Also, they reported in their study the WBCs count was directly proportional to BMI [3].…”

Section: Introductionmentioning

confidence: 90%

“…White blood cells (WBCs) count is elevated in obesity and is risk factor for atherosclerosis and is present in impaired glucose tolerance (IGT) which is associated with Marco and Micro-angiopathic complication in type 2 diabetes, the effect is more marked in obese patient [9]. Research has shown that obese adults, (BMI--30 kg/m 2 ), have elevated total leukocytes [3] elevation of leukocytes appears to be related to monocytes [10]; however, neutrophils, eosinophils, and lymphocytes may be elevated [11]. And weight loss is important in reducing WBCs count in morbid obesity, simple or complicated by IGT or type 2 Diabetes [9].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Total White Blood Cells in Obese Subject in Khartoum State 2017

Ali¹

2019

HIJ

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Background: This research aimed to investigate the effect of obesity WBCs count and to compare WBCs count of obese subjects early in the morning and in the late evening to explore the effect of normal activates on TWBCs. Methods: Across sectional facility-based study was conducted in the Khartoum state during the period of Sep 2017 to Nov 2017 among Sudanese obese subjects of age between 15-45 years old Result: There is variation in number of TWBS early in the morning comparing to late in the evening.The mean value of TWBCs for morning was 6.29 with standard deviation of 1.75 and the mean of TWBS result for evening is 7.37 with standard deviation of 1.78. The pair sample T test was significant with a P value 0.00 Conclusion: There is significant increase in number of TWBCs at the end of the day in obese subject, the cause may be due to the normal activity of obese considered as exercise.

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Community-based hematological reference intervals among apparently healthy adult Eritrean population in Asmara

Noury

Musa

Gasmalbari

et al. 2023

Preprint

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Background: The complete blood count (CBC) is one of the most beneficial biological tests used in routine medical practice. The reference intervals (RIs) of the hematological parameters are of major importance for clinical orientations and therapeutic decisions and it is necessary to establish RIs that are population specific. The objective of this study was to establish population-specific reference intervals for hematological parameters among healthy adult Eritreans. Method: Using a DXH500 analyzer, CBC values were evaluated in samples taken from 401 healthy Eritreans in Asmara city, ranging in age from 18 to 60. For the blood tests, a sample of venous blood was drawn into a tube containing the anticoagulant EDTA. Data analysis was done using SPSS version 25, and a P value of 0.05 or above was deemed significant. The upper (97.5th percentile) and lower (2.5th percentile) reference interval boundaries with 95% CI were determined using a non-parametric test. The necessity for gender-based reference interval partitioning was determined using the Harris and Boyd Rule. Results: The established 95% reference intervals combined median (2.5th 97.5th percentile) were: that represent both males and females as per the suggestion of Harris and Boyd WBCs, Lymphocytes, Monocytes, Neutrophils, Eosinophils, Basophils, MCV, RDW, RDW-SD and MPV (fl) were 6.3(3.62-11.56x103/microliter), 39.53(22.10-60.55 %), 8.67(5.70-13.61 %), 49.32(27.09-69.25 %), 1.19(0.22-7.13%), 0.17(0.02-0.61%), 88.10(79.32-96.07fl), 13.50(12.50-15.90 %), 37.25(33.00-43.29%), and 9.29(7.76-11.51fl) respectively. RBCs, Hb, HCT, MCH, MCHC, and platelets were the parameters that required separate RI. Their respective median (2.5th 97.5th percentile) for males versus females were 5.40 (4.57-6.21 x106/microliter) versus 4.88 (4.25-5.61x106/microliter), 15.66 (13.56-18.13 g/dl) versus 13.50 (11.95-15.68 g/dl, 48 (42.02-53.93%) versus 42.60 (36.40-48.52%), 29.10 (26.02-34.74 pg) versus 28.30 (24.79-31.02 pg), 32.55 (31.60-36.14 g/dl) versus 32.20 (31.10-33.50 14 g/dl) and 273.15 (155.67-399.34) versus 314.35 (113.96-499.55 103/microliter). Conclusion: The reference intervals established in this study differ from currently used RIs and thus should be used for the interpretation of laboratory results in diagnosis and safety monitoring in clinical trials in Asmara

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Normal range of white blood cells and differential count of Sudanese in Khartoum state

Cited by 7 publications

References 18 publications

Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa

Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa

Evaluation of Total White Blood Cells in Obese Subject in Khartoum State 2017

Community-based hematological reference intervals among apparently healthy adult Eritrean population in Asmara

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