Normal values correlates of carotid intima- media thickness and affecting parameters in healthy adults

Abstract

ÖZETAmaç: Karotis arter intima-media kalınlık (KİMK) değişiklikleri ile aterosklerotik sürecin başlangıcını erken dönemde ortaya koymak mümkün-dür. Türk toplumunda normal bireylerin KİMK'ları incelenmemiştir. Bu çalışmada ateroskleroz yönünden risk faktörleri olmayan normal bireylerde KİMK ve etkileyen parametrelerin incelenmesi amaçlandı. ABSTRACTObjective: Early changes in atherosclerosis can be diagnosed by the carotid artery intima-media thickness (CIMT) measurement. Normal range of CIMT in healthy subjects has not been studied yet in our country. Therefore, the aim of this study was to measure the CIMT in healthy individuals and investigate affecting parameters of CIMT. Methods: Overall, 2298 subjects, aged 18 to 92 years were undergone CIMT measurement in this observational cohort study. 151 healthy adult subjects, aged 20 to 79 year without atherosclerotic risk factors, normal body mass index and normal metabolic parameters were selected to establish normative CIMT values. Correlations between CIMT and atherosclerotic risk factors were evaluated in the Turkish population. The independent variables associated with CIMT were evaluated with multiple linear regression analysis. Results: CIMT value was 0.458±0.116 mm in males and 0.47±0.104 mm in females. Mean values of CIMT (in mm) for healthy reference sample aged 20-29, 30-39, 40-49, 50-59, 60-69 and 70-79 years were 0.402; 0.466; 0.492; 0.586; 0.692 and 0.733, respectively. CIMT increased significantly (p<0.001) by 0.066 mm, in every decade. Correlates of CIMT were age, visceral fat level, fasting serum glucose, total and low-density lipoprotein

Correlation between adipokines and carotid intima media thickness in a group of obese Romanian children: is small for gestational age status an independent factor for cardiovascular risk?

“…An increase in CIMT with each decade of age (0.066 cm/decade) was observed, with CIMT values as high as 0.0733 cm in the 70-79 years group (44). An increase of 0.1 mm in CIMT is known to raise the risk of myocardial infarction by 11% (45).…”

Correlations Between Endothelial Dysfunction and Cerebral Imaging in Migraine

“…Nitric oxide (NO) is responsible for trigeminovascular inflammation during migraine attacks (14). During migraine, endothelial NO and superoxide anions increase in the cerebral blood flow (15,16).…”

“…CCA-IMT, a structural marker of early atherosclerosis was increased in migraineurs, this elevation with patients and controls was excluded. According to a large-scale study on the same race performed in 2012, the CCA-IMT normal value was 0.458±0.116 mm in males and 0.47±0.104 mm in females (15).…”

“…In order to assess endothelial function correctly in the study, the criterion was that had no attack in the last 15 Öz the normal references of the blood parameters may change. In this study, we investigated the contribution of instability to the period without attack.…”

The value of carotid intima-media measurements during the periods of attack and remission of migraine disease and tension-type headache in differential diagnosis

“…In the observational cohort study conducted by Beşir et al in 2010 in Turkey, it was found that CIMT values in healthy volunteers increased only by age and it has been found that CIMT measurement can be used to evaluate early atherosclerosis burden in adult individuals [14]. Recent studies have shown that the risk of ischaemic stroke is high in patients with migraine, especially in women with migraine with aura [15,16].…”