Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease

Wu, Chao; Wu, Haoting; Zhou, Cheng; Guan, Xiaojun; Guo, Tao; Cao, Zhengye; Wu, Jingjing; Liu, Xiaocao; Chen, Jingwen; Wen, Jiaqi; Qin, Jianmei; Tan, Sijia; Duanmu, Xiaojie; Zhang, Baorong; Huang, Peiyu; Xu, Xiaojun; Zhang, Minming

doi:10.1002/hbm.26316

Cited by 7 publications

(1 citation statement)

References 63 publications

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“…On the other hand, other authors found an increased cerebellar FC 25 – 29 , and others an increased FC with some regions and a decreased FC with others 30 – 32 . Moreover, some authors found a correlation between the increased FC connectivity and the clinical features of patients 26 – 29 the presence or not of dopaminergic treatment 31 , 33 while a decreased cerebellar FC has been related to a reduced cognitive performance 23 .…”

Section: Discussionmentioning

confidence: 99%

Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study

Pietracupa,

Ojha,

Belvisi

et al. 2024

npj Parkinsons Dis.

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Increasing evidence suggests that the cerebellum may have a role in the pathophysiology of Parkinson’s disease (PD). Hence, the scope of this study was to investigate whether there are structural and functional alterations of the cerebellum and whether they correlate with motor and non-motor symptoms in early PD patients. Seventy-six patients with early PD and thirty-one age and sex-matched healthy subjects (HS) were enrolled and underwent a 3 T magnetic resonance imaging (MRI) protocol. The following MRI analyses were performed: (1) volumes of 5 cerebellar regions of interest (sensorimotor and cognitive cerebellum, dentate, interposed, and fastigial nuclei); (2) microstructural integrity of the cerebellar white matter connections (inferior, middle, and superior cerebellar peduncles); (3) functional connectivity at rest of the 5 regions of interest already described in point 1 with the rest of brain. Compared to controls, early PD patients showed a significant decrease in gray matter volume of the dentate, interposed and fastigial nuclei, bilaterally. They also showed abnormal, bilateral white matter microstructural integrity in all 3 cerebellar peduncles. Functional connectivity of the 5 cerebellar regions of interest with several areas in the midbrain, basal ganglia and cerebral cortex was altered. Finally, there was a positive correlation between abnormal functional connectivity of the fastigial nucleus with the volume of the nucleus itself and a negative correlation with axial symptoms severity. Our results showed that structural and functional alterations of the cerebellum are present in PD patients and these changes contribute to the pathophysiology of PD in the early phase.

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Section: Discussionmentioning

confidence: 99%

Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study

Pietracupa,

Ojha,

Belvisi

et al. 2024

npj Parkinsons Dis.

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Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease

Zhou

et al. 2023

Human Brain Mapping

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Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under long‐term DRT, and 94 normal control (NC) were, retrospectively, enrolled. Resting‐state functional magnetic resonance imaging data and motor symptom assessments were conducted before and after levodopa challenge test. Whole‐brain functional connectivity (FC) matrices were constructed. Network‐based statistics were performed to assess FC difference between drug‐naïve patients and NC, and these significant FCs were defined as disease‐related connectomes, which were used for further statistical analyses. Patients showed better motor performances after both long‐term DRT and levodopa challenge test. Two disease‐related connectomes were observed with distinct patterns. The FC of the increased connectome, which mainly consisted of the motor, visual, subcortical, and cerebellum networks, was higher in drug‐naïve patients than that in NC and was normalized after long‐term DRT (p‐value <.050). The decreased connectome was mainly composed of the motor, medial frontal, and salience networks and showed significantly lower FC in all patients than NC (p‐value <.050). The global FC of both increased and decreased connectome was significantly enhanced after levodopa challenge test (q‐value <0.050, false discovery rate‐corrected). The global FC of increased connectome in ON‐state was negatively associated with levodopa equivalency dose (r = −.496, q‐value = 0.007). Higher global FC of the decreased connectome was related to better motor performances (r = −.310, q‐value = 0.022). Our findings provided insights into brain functional alterations under dopaminergic medication and its benefit on motor symptoms.

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Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia

Piramide,

De Micco,

Siciliano

et al. 2024

Curr Neurol Neurosci Rep

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Purpose of the Review In this review, we attempt to summarize the most updated studies that applied resting-state functional magnetic resonance imaging (rs-fMRI) in the field of Parkinsonisms and related dementia. Recent Findings Over the past decades, increasing interest has emerged on investigating the presence and pathophysiology of cognitive symptoms in Parkinsonisms and their possible role as predictive biomarkers of neurodegenerative brain processes. In recent years, evidence has been provided, applying mainly three methodological approaches (i.e. seed-based, network-based and graph-analysis) on rs-fMRI data, with promising results. Summary Neural correlates of cognitive impairment and dementia have been detected in patients with Parkinsonisms along the diseases course. Interestingly, early functional connectivity signatures were proposed to track and predict future progression of neurodegenerative processes. However, longitudinal studies are still sparce and further investigations are needed to overcome this knowledge gap.

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Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease

Cited by 7 publications

References 63 publications

Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study

Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study

Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease

Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia

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