Normative data of Visual Evoked Potential in children and correlation with age

Abstract

Background: Visual Evoked Potential is the assessment of the visual pathway and the visual cortex. The present study was descriptive analysis of normal VEP between the age of 6 months to 4 years of age and the determination of the neuronal development among healthy children of above age group. Materials and Methods: The study was conducted in neurological lab of BPKIHS on healthy children (n=36) of well-baby clinic between the age of 0.5 to ≤4 years (yr). Subjects were divided into subgroup 1(0.5 to ≤2 yr), subgroup 2(2 to ≤3 yr) and subgroup 3(3 to ≤4 yr). Visual stimulator provided with fl ash light emitting diode (LED) goggle was used to stimulate the retina and VEP recording was done. Flash VEP parameters: latencies (N90, P120) and amplitude (N90-P120) were recorded. Post hoc (Bonferroni) analysis was done for comparing VEP variables. Pearson correlation were done for VEP with respect to age. Results: VEP latencies of children, age-group 3 to ≤4 yr showed signifi cantly less N90 latency on right eye stimulation comparing age-group 0.5 to ≤2 yr (103.75±22.54 vs. 79.09±17.77ms, p=0.012). P120 latency was signifi cantly less on right eye stimulation (148.5±15.38 vs.116.67±13.65ms p=0.001) and on left eye stimulation (145.91±18.11 vs. 116.67±13.65 ms, p=0.001) in age-group 3 to ≤4 yr children as compared to age-group 0.5 to ≤2 yr. Conclusion: Signifi cant decrement of VEP latencies as age advances which explains the maturation of central nervous system and functionally approaching to adult value at around 3 to 4 yr.

Normative values of visual evoked potentials in Northeastern of Iran

“…A total 59 students of Mashhad University of Medical Sciences (32 females and 27 males) participated in this study. Since the morphologic and metabolic maturation of the visual cortex completes at the age of 18 and VEPs components are not affected after this age,19, 20 we selected participants who were 18 years and older (22.55 ± 3.79 years old). All participants had normal general and ocular health and their best-corrected visual acuity was 6/6 or better in each eye at 6 m. The procedures of this study were approved by the local Human Research Ethics Committee and were in conformity with the Helsinki Declaration.…”

“…The latency values of VEPs for large checks and small checks reached adult levels respectively at 1 and 5 year of age 20 and the amplitudes of VEPs were not affected by age after 1 years 22, 23. Moreover, most studies have reported that the maturation of the visual pathway occurs around 4 years of age 20, 22, 24…”

“…Longer latency of P100 occurs in the elderly and in males than females 14, 16. Numerous studies have assessed the maturation of visual system using VEPs and have observed earlier maturation for larger check sizes than smaller ones 19, 20, 21, 22. The latency values of VEPs for large checks and small checks reached adult levels respectively at 1 and 5 year of age 20 and the amplitudes of VEPs were not affected by age after 1 years 22, 23.…”

“…Numerous studies have assessed the maturation of visual system using VEPs and have observed earlier maturation for larger check sizes than smaller ones 19, 20, 21, 22. The latency values of VEPs for large checks and small checks reached adult levels respectively at 1 and 5 year of age 20 and the amplitudes of VEPs were not affected by age after 1 years 22, 23. Moreover, most studies have reported that the maturation of the visual pathway occurs around 4 years of age 20, 22, 24…”

Visual Evoked Potentials in Operated Primary Congenital Glaucoma: A Cross-Sectional Comparative Study

“…The study was conducted on 34 (19 1. The mean age of the control children was slightly higher than the study children, though not statistically significant (p=0.217).…”