Ports are characterized by several complex operations. Accordingly, the analysis of noise results is complicated due to the presence in the same area of diverse sound from ships, trade and also from industrial and shipyards activities as well as auxiliary services producing negative effects on natural ecosystem and the urban population. The ENPI CBC MED project Managing the Environmental Sustainability of Ports for a durable development (MESP) addressed the pollution reduction from port activities through the implementation of a multidisciplinary approach in air, noise and water sectors, encompassing technological, regulatory and administrative solutions to ensure natural and urban sustainability and high level of life quality in surrounding territories. To prevent a heterogeneous development, the "status quo" of ports in Northern and Southern Shores of the Mediterranean Sea was analyzed and a guideline on methodologies, good practices and measurement assessment, adaptable and transferable in different port contexts was elaborated. To assess the procedures, validation tests have been carried out to different real cases. In noise sector pilot projects in the ports of Patras, Greece, and Tripoli, Lebanon, have been implemented. Due to the dissimilar scenarios, in terms of orography, facilities and activities, different noise mitigation actions and interventions were consequently accomplished.