Normative values for intima–media thickness and distensibility of large arteries in healthy adolescents

Jourdan, Claudia; Wühl, Elke; Litwin, Mieczysław; Fahr, K.; Trelewicz, Justyna; Jobs, Katarzyna; Schenk, Jens‐Peter; Grenda, Ryszard; Mehls, Otto; Tröger, J.; Schaefer, Franz

doi:10.1097/01.hjh.0000178834.26353.d5

Cited by 319 publications

(290 citation statements)

References 50 publications

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“…The arterial stiffening as well as the IMT have shown to be associated with increased morbidity and mortality 38,39 . Recently, studies showing a correlation between SAH and PP observed in infancy and adolescence and the presence of arterial stiffening and IMT in young adults have been published [40][41][42][43] , indicating that the processes identifi ed in the elderly are also present in younger individuals. Studies with healthy young adults of both sexes also showed that the intima-media thickening (IMT) and aortic stiffening seem to refl ect two different entities of vascular damage, with IMT alone being associated to LDL-cholesterol and BMI 44,45 .…”

Section: Discussionmentioning

confidence: 99%

Pré-hipertensão arterial e pressão de pulso aumentada em adolescentes: prevalência e fatores associados

Rosa¹,

Fonseca²,

Oigman³

et al. 2006

Arq. Bras. Cardiol.

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OBJECTIVETo estimate the prevalence of prehypertension and elevated pulse pressure in adolescents and assess the association between those two conditions and sex, age, sexual development, obesity and physical activity. METHODSAnthropometrical data and blood pressure were measured in and a questionnaire was applied to 456 adolescents (aged 12 to 17 years) recruited from public and private schools, in the Fonseca district, in the city of Niterói, state of Rio de Janeiro, Brazil, from 2003 to 2004. RESULTSThirty nine (8.6%) presented prehypertension (PH) and 13.4%, elevated pulse pressure (PP). At bivariate analysis, PH was signifi cantly associated with sex, age and obesity, with more prevalent in boys aged between 15 and 17 years, and in the obese. Elevated PP was associated with gender only, as it was more prevalent in boys. Sexual maturation did not show an association with PH or elevated PP. Similar correlations were found at logistic regression. PH prevalence odds ratio was 7.7 for sex, 4.3 for age and 4.6 for obesity. Elevated PP prevalence odds ratio was 10.8 for sex. The correlation between PP and physical activity was positive and signifi cant. The elevation of PP was attributable to systolic blood pressure. CONCLUSIONPH and the elevated PP were shown to be present in adolescents from a population with a low prevalence of hypertension, mostly in boys. Further prospective studies are necessary to assess the persistence and the impact of those conditions.

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Section: Discussionmentioning

confidence: 99%

Pré-hipertensão arterial e pressão de pulso aumentada em adolescentes: prevalência e fatores associados

Rosa¹,

Fonseca²,

Oigman³

et al. 2006

Arq. Bras. Cardiol.

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“…Patients with underlying vasculitis, diabetes, uncontrolled hyperlipidemia (serum cholesterol Ն5 mMol/L despite statin therapy), uncontrolled hypertension (systolic BP Ն95th centile for age despite therapy), and smokers were excluded. Because vascular measures are age dependent and normative data are available only for children who were older than 10 yr, 38 we compared our patient group with 40 age-and gendermatched healthy control subjects who were studied contemporaneously.…”

Section: Methodsmentioning

confidence: 99%

Mineral Metabolism and Vascular Damage in Children on Dialysis

Shroff

Donald²,

Hiorns

et al. 2007

Journal of the American Society of Nephrology

199

151

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Cardiovascular disease is increasingly recognized as a life-limiting problem in young patients with chronic kidney disease, but there are few studies in children that describe its determinants. We studied the association of intact parathyroid hormone (iPTH) levels and their management on vascular structure and function in 85 children, ages 5-18 years, who had received dialysis for Ն6 months. Compared to controls, dialysis patients had increased carotid intima-media thickness and pulse-wave velocity. All vascular measures positively correlated with serum phosphorus levels, while carotid intima-media thickness and cardiac calcification score also correlated with iPTH levels. Patients with mean time-integrated iPTH levels less than twice the upper limit of normal (n ϭ 41) had vascular measures that were comparable to age-matched controls, but those with iPTH levels greater than twice the upper limit of normal (n ϭ 44) had greater carotid intima-media thickness, stiffer vessels, and increased cardiac calcification than controls. Patients with increased carotid intima-media thickness had stiffer vessels and a greater prevalence of cardiac calcification. There was a strong dose-dependent correlation between vitamin D and all vascular measures, and calcium intake from phosphate binders weakly correlated with carotid intima-media thickness. In conclusion, both iPTH level and dosage of vitamin D are associated with vascular damage and calcification in children on dialysis.

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“…During the last decade, multiple reports have been published that support using cIMT and PWV measurements to evaluate target organ damage, and pediatric reference values for cIMT and PWV have been published (Table V and VI) [37][38][39][40][41][42]. These tests are already recommended (ESH 2016) as additional in the assessment of target organ damage in children with AH.…”

Section: Non-obligatory Additional Tests To Evaluate the Extent Of Tamentioning

confidence: 99%

Zalecenia Sekcji Pediatrycznej Polskiego Towarzystwa Nadciśnienia Tętniczego dotyczące postępowania diagnostycznego i terapeutycznego w nadciśnieniu tętniczym u dzieci i młodzieży

Litwin

Niemirska

Obrycki

et al. 2018

Arterial Hypertension

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Presented recommendations are an extended and actualized version of paediatric recommendations of Polish Society of Hypertension published in 2015. Since then, new studies have appeared on this subject, introducing a new classification of hypertension, newly described principles of management in risk groups and methods of assessing hypertensive target organ damage. The presented updated recommendations included changes introduced in the 2016 European Society of Hypertension recommendations and Recommendations of Children's Memorial Health Institute in Warsaw. Recently published guidelines of American Academy of Pediatrics have been discussed. In the presented issue of guidelines, epidemiological information on the occurrence and incidence of hypertension in developmental age was added and classification of blood pressure values was updated. Subchapters on diagnosis and organ damage assessment, principles of diagnosis and treatment of hypertension in children with diabetes, chronic kidney disease and a subsection discussing diagnostic and therapeutic difficulties with setting blood pressure targets were revised. In addition, the principles of early diagnosis of arterial hypertension in post-hospital care in children born before 33 weeks of gestation published in 2018 as recommendations of the Polish Neonatal Society have been also taken into account.

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Normative values for intima–media thickness and distensibility of large arteries in healthy adolescents

Abstract: Morphological and functional measures of large arteries should be normalized to take account of changes during adolescence and skewed distributions. Relative body mass, systolic blood pressure and/or pulse pressure are determinants of IMT and elasticity.

Cited by 319 publications

References 50 publications

Pré-hipertensão arterial e pressão de pulso aumentada em adolescentes: prevalência e fatores associados

Pré-hipertensão arterial e pressão de pulso aumentada em adolescentes: prevalência e fatores associados

Mineral Metabolism and Vascular Damage in Children on Dialysis

Zalecenia Sekcji Pediatrycznej Polskiego Towarzystwa Nadciśnienia Tętniczego dotyczące postępowania diagnostycznego i terapeutycznego w nadciśnieniu tętniczym u dzieci i młodzieży

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