Normative Values of Peripapillary Retinal Nerve Fiber Layer Thickness in a Middle Eastern Population

Abstract

Purpose Peripapillary retinal nerve fiber layer (pRNFL) thickness is subject to high variability. Normative values of pRNFL thickness remain undocumented in the Middle East. The aim of our study is to assess the normative values of pRNFL thickness in a Middle Eastern population. Methods A retrospective chart review of 74 patients was conducted. Outpatients who had presented to the ophthalmology clinic at the Jordan University Hospital between January 2016 and July 2018 were consecutively sampled. Measurements had been recorded using Fourier-domain optical coherence tomography. Multivariable regression models were developed to generate predicted normative values with adjustments to candidate confounders. Results The mean global pRNFL thickness was 99 ± 11 μm. The mean quadrantic pRNFL thickness increased from the nasal quadrant (75 ± 16 μm) to the temporal (82 ± 20 μm), superior (114 ± 20 μm), and inferior (125 ± 20 μm) quadrants. Gender and eye sidedness did not contribute to the variability in pRNFL thickness. The relationship between aging and pRNFL thinning is independent of diabetes mellitus type 2 and systemic hypertension. Both systemic conditions significantly predicted pRNFL changes despite negative fundoscopic findings. Conclusions Our set of predicted normative data may be used to interpret measurements of pRNFL thickness in Middle Eastern patients. Our findings suggest that systemic conditions with potential ocular manifestations may require consideration in predictive models of pRNFL thickness, even in the absence of gross fundoscopic findings. Normative data from additional Middle Eastern populations are required to appraise our models, which adjust for common clinical confounders.

Normative values of the retinal macular thickness in a middle eastern population

“…This value is consistent with that of the previous studies on the Caucasian population using the Spectrally OCT 270+/− 22.5 um [4,10]. Based on previous studies we have noticed that middle Eastern population sample investigated in our study had thinner central foveal thickness when compared to the Iranian population but thicker than other populations like African Americans, Japanese White American, Indians and blacks (5,11,(16)(17)(18)(19)(20). Moreover, the results are variable when compared to other Caucasians [8].…”

“…The central area of the fovea increased with age while the thickness in the other areas decreased. Other areas of the retina were evaluated in the Middle Eastern population namely, the peri-papillary nerve fiber layer, this analysis concluded that the thickness in various areas is consistent with previous studies [19], Essentially, the African-American race was a predictor of decreased mean foveal thickness when compared to Caucasians and Hispanics.…”

Normative Values of The Retinal Macular Thickness in a Middle Eastern Population.

“…The central area of the fovea increased with age while the thickness in the other areas decreased. Another areas of the retina was evaluated in the Middle Eastern population namely, the peri-papillary nerve fiber layer, this analysis concluded that the thickness in various areas is consistent with previous studies [20 ], Essentially, the African-American race was a predictor of decreased mean foveal thickness when compared to Caucasians and Hispanics. Furthermore, males were associated with increased mean foveal thickness.…”

Normative Values of The Retinal Macular Thickness in a Middle Eastern Population.

“…Japanese have thicker retinas compared to the US population using Stratus OCT [18]. concluded that the thickness in various areas is consistent with previous studies [20], Essentially, the African-American race was a predictor of decreased mean foveal thickness when compared to…”

“…Refractive error didn't statistically add to the prediction model. Americans, Japanese White American, Indians and blacks (5,11,(16)(17)(18)(19)(20). Moreover, the results are variable when compared to other Caucasians [9].…”