Normocapnic High Frequency Oscillatory Hyperventilation Increases Oxygenation in Pigs

Roubík, Karel; Pachl, J.; Zábrodský, V.

doi:10.33549/physiolres.932123

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…The most common ARDS model induced by normal saline lung lavage does not represent a typical ARDS lung as ARDS in patients is rarely, if ever, solely a result of surfactant deficiency. Nevertheless, the effect of HFOV hyperventilation observed in this study in healthy animals corresponds to the results of an HFOV hyperventilation study conducted in a porcine ARDS model induced by saline lavage [ 43 ]. Hyperventilation with V T increased to 135% of its normocapnic value increased P a O 2 by 31 mmHg in the current study; whereas V T increased to 146% caused an increase in P a O 2 by 28 mmHg in the saline lavage ARDS model in pigs.…”

Section: Discussionsupporting

confidence: 76%

Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation

et al. 2022

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Background The role of high-frequency oscillatory ventilation (HFOV) has long been debated. Numerous studies documented its benefits, whereas several more recent studies did not prove superiority of HFOV over protective conventional mechanical ventilation (CV). One of the accepted explanations is that CV and HFOV act differently, including gas exchange. Methods To investigate a different level of coupling or decoupling between oxygenation and carbon dioxide elimination during CV and HFOV, we conducted a prospective crossover animal study in 11 healthy pigs. In each animal, we found a normocapnic tidal volume (VT) after the lung recruitment maneuver. Then, VT was repeatedly changed over a wide range while keeping constant the levels of PEEP during CV and mean airway pressure during HFOV. Arterial partial pressures of oxygen (PaO2) and carbon dioxide (PaCO2) were recorded. The same procedure was repeated for CV and HFOV in random order. Results Changes in PaCO2 intentionally induced by adjustment of VT affected oxygenation more significantly during HFOV than during CV. Increasing VT above its normocapnic value during HFOV caused a significant improvement in oxygenation, whereas improvement in oxygenation during CV hyperventilation was limited. Any decrease in VT during HFOV caused a rapid worsening of oxygenation compared to CV. Conclusion A change in PaCO2 induced by the manipulation of tidal volume inevitably brings with it a change in oxygenation, while this effect on oxygenation is significantly greater in HFOV compared to CV.

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Section: Discussionsupporting

confidence: 76%

Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation

et al. 2022

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Minute ventilation stabilization during all pressure-control / support mechanical ventilation modes

Candik¹,

Depta²,

Imrecze³

et al. 2020

Physiol Res

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The main goal of our prospective randomized study was comparing compare the effectiveness of ventilation control method „Automatic proportional minute ventilation (APMV) “versus manually set pressure control ventilation modes in relationship to lung mechanics and gas exchange. 80 patients undergoing coronary artery bypass grafting (CABG) were randomized into 2 groups. 40 patients in the first group No. 1 (APMV group) were ventilated with pressure control (PCV) or pressure support ventilation (PSV) mode with APMV control. The other 40 patients (control group No.2) were ventilated with synchronized intermittent mandatory ventilation (SIMV-p) or pressure control modes (PCV) without APMV. Ventilation control with APMV was able to maintain minute ventilation more precisely in comparison with manual control (p<0.01), similarly deviations of ETCO2 were significantly lower (p<0.01). The number of manual corrections of ventilation settings was significantly lower when APMV was used (p<0.01). The differences in lung mechanics and hemodynamics were not statistically significant. Ventilation using APMV is more precise in maintaining minute ventilation and gas exchange compared with manual settings. It required less staff intervention, while respiratory system mechanics and hemodynamics are comparable. APMV showed as effective and safe method applicable on top of all pressure control ventilation modes.

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Avaliação dos efeitos hemodinâmicos da VAFO na síndrome de angústia respiratória grave – relato de caso

et al. 2011

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Introdução: A síndrome do desconforto respiratório agudo (SDRA) é uma condição clínica grave, e a ventilação mecânica é a terapia de suporte nessa situação. A ventilação de alta frequência oscilatória (VAFO) pode ser considerada uma estratégia de ventilação pulmonar protetora ideal; no entanto, alguns estudos indicam que ela pode provocar deterioração hemodinâmica. Objetivo: Avaliar os efeitos hemodinâmicos da VAFO. Método: Relato de caso de uma menina de 1 ano de idade, com SDRA sem resposta ao tratamento convencional, evoluindo para deterioração hemodinâmica. Resultados: Após a VAFO houve melhora nas variáveis hemodinâmicas, desmame de drogas vasoativas e aumento da diurese. O índice de oxigenação (IO) reduziu mais de 50% nas primeiras 24 horas. A VAFO foi utilizada durante 11 dias com o retorno à ventilação mecânica convencional em parâmetros mínimos. Conclusão: A VAFO pode ser usada como terapia de resgate mesmo que as condições hemodinâmicas não sejam favoráveis em paciente com SDRA grave.

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Normocapnic High Frequency Oscillatory Hyperventilation Increases Oxygenation in Pigs

Cited by 3 publications

References 12 publications

Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation

Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation

Minute ventilation stabilization during all pressure-control / support mechanical ventilation modes

Avaliação dos efeitos hemodinâmicos da VAFO na síndrome de angústia respiratória grave – relato de caso

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