Normolipemic papular xanthomatosis in erythrodermic atopic dermatitis

Goerdt, Sergij; Kretzschmar, Lars; Bonsmann, Giesela; Luger, Thomas A.; Kolde, G.

doi:10.1016/0190-9622(95)90397-6

Cited by 15 publications

(3 citation statements)

References 32 publications

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“…Clinical and histopathological features (including variable expression of immunophenotypic markers) and the usually benign clinical course of NLCH are indicative of a reactive process rather than a clonal disorder 2,6 . Several conditions have been described that can precipitate the development of NLCH: papular xanthoma and generalized eruptive histiocytoma have been observed in patients with severe atopic dermatitis, 12 and generalized eruptive histiocytoma has been reported in association with malignancy or other systemic disorders 13 . It is therefore conceivable that in our patients the inflammatory reaction associated with LCH may have initiated the pathogenetic process that led ultimately to JXG.…”

Section: Discussionmentioning

confidence: 99%

Juvenile xanthogranuloma as a sequel to Langerhans cell histiocytosis: a report of three cases

Hoeger

Díaz

Malone

et al. 2001

Clinical and Experimental Dermatology

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We report three children who had multisystem Langerhans cell histiocytosis (LCH) with cutaneous involvement and subsequently developed juvenile xanthogranuloma (JXG). JXG appeared 3--6 years after the initial manifestation of LCH. JXG lesions, which presented as yellowish papules, revealed typical Touton giant cells and were factor XIIIa positive but S100 and CD1a negative. Non-LCH histiocyte disorders, such as JXG, are known to occur as a reaction to a variety of external stimuli such as infection and trauma. It is therefore conceivable that the inflammatory reaction associated with LCH may have precipitated the development of JXG in our patients. Alternatively, one could speculate that this association might be due to a common histogenetic precursor of the cell types involved.

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Section: Discussionmentioning

confidence: 99%

Juvenile xanthogranuloma as a sequel to Langerhans cell histiocytosis: a report of three cases

Hoeger

Díaz

Malone

et al. 2001

Clinical and Experimental Dermatology

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“…Normolipidaemic xanthoma occurs primarily in xanthoma disseminatum and juvenile xanthogranuloma or secondarily by altered lipoprotein, underlying lymphoproliferative diseases and local tissue alteration. 10 In most reported cases, papular xanthoma is normolipidaemic and occurs primarily, but it has occasionally been reported as secondary to other disorders. 10–13 Chen et al .…”

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confidence: 99%

“… 10 In most reported cases, papular xanthoma is normolipidaemic and occurs primarily, but it has occasionally been reported as secondary to other disorders. 10–13 Chen et al . 6 suggested the term ‘primary papular xanthoma’ to describe papular xanthoma without any underlying disease, as in our case.…”

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confidence: 99%