Nosocomial diarrhea in children: is astrovirus the leading pathogen?

Chakravarti, Anita; Jain, Manisha; Chauhan, Mohit; Sharma, Anju; Tewari, Sayani

doi:10.1016/s1995-7645(10)60100-9

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Human astrovirus has been associated with nosocomial infections and that could be the reason for such high incidence observed in our study 46. A recent report from New Delhi showed that astrovirus accounted for almost 33% cases of acute diarrhea in children less than 2 years of age 47. Thus, astrovirus-associated nosocomial diarrhea could be an emerging problem.…”

supporting

confidence: 52%

Changing pattern of prevalence, genetic diversity, and mixed infections of viruses associated with acute gastroenteritis in pediatric patients in New Delhi, India

Gupta

Krishnan

Sharma

et al. 2017

Journal of Medical Virology

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There are very few studies that have assessed multiple viral agents causing Acute-Gastroenteritis (AGE) in India. The present study compared the changing pattern of prevalence and genetic diversity of five enteric viruses associated with acute-diarrhea in Delhi children within a gap of 5 years. Fecal samples were collected from diarrheal children (<4 years) during two winter seasons: year 2009-2010 (n = 59) and year 2014-2015 (n = 85). Samples were individually tested for rotavirus-A, norovirus, astrovirus, adenovirus, and sapovirus using EIA/RT-PCR and genetically characterized by phylogenetic analysis. Rotavirus was the most predominant (54.9%) virus followed by norovirus (25.7%), astrovirus (8.3%), and adenovirus (4.9%) with rare detection of sapovirus (0.7%). While detection rate increased for both rotavirus (49.2-58.8%) and astrovirus (5.1-10.6%), norovirus detection rate decreased (30.5-22.4%) from 2009 to 2015. During the same time period, adenovirus detection remained low (4.7-5.1%). Interestingly, mixed infections increased from 8.5% to 16.5% after 5 years. G1P[8] rotavirus strain was found most predominant (40%). Both type-1 and 8 astroviruses were detected. Single sapovirus detected was of genotype GII.1. Both GI (GI.5, GI.3) and GII (GII.1, GII.4, GII.7, GII.21, GII.13) genogroups of norovirus were detected. Of particular significance was the first detection of other NoV genotypes (besides GII.4 and GI.3) in Delhi. This is also the first report of NoV GI.5 from India. A change in prevalence pattern and increased diversity from 2009 to 2015 emphasizes the need for continued enteric virus surveillance to help measure the impact of new diarrhea vaccine(s) introduced in India.

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supporting

confidence: 52%

Changing pattern of prevalence, genetic diversity, and mixed infections of viruses associated with acute gastroenteritis in pediatric patients in New Delhi, India

Gupta

Krishnan

Sharma

et al. 2017

Journal of Medical Virology

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“…Desde então, estes vírus são frequentemente descritos no mundo inteiro em casos de infecções entéricas em humanos sugerindo-se como a segunda principal causa de gastroenterite em crianças depois dos rotavírus (CHAKRAVARTI et al, 2010).…”

Section: Revisão De Literaturaunclassified

<b>Detecção e genotipagem de astrovírus em amostras fecais de aves de produção procedentes de diferentes criações comerciais brasileiras</b>

Espinoza¹

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AGRADECIMENTOSGostaria de agradecer, pela oportunidade de continuar a crescer e cumprir um dos objetivos na procura dos meus sonos e ideais:A Universidade de São Paulo, pelo espaço onde esteve a desenvolver não apenas o pensamento cientifica, as pessoas, os serviços e os espaços de entretenimento.Por ter a oportunidade de trabalhar com alguém que soube me orientar e corrigir nos momentos indicados, pelos ensinamentos e conselhos, ao Professor Fabio Gregori.Aos professores do Departamento de Medicina Veterinária Preventiva e Saúde Animal, por serem sempre tão receptivos amáveis e abertos a conversa, pela disposição e tempo, com certeza isso contribui de grande maneira na minha formação.Aos funcionários do Departamento, por serem tudo de bom comigo, por sua ajuda e diversas orientações.A todos os colegas, dos diversos laboratórios do departamento, pelas conversas, piadas, conselhos, não gostaria de colocar nomes, porque guardo grande estima a todo eles.Aos colegas de outras faculdades, que conheci no decorrer deste tempo, brasileiros e estrangeiros, por que a traves de eles aprendi que todos somos iguais, e que podemos viver juntos em perfeita paz e amizade.A CAPES (Processo: 5881-11-0 PEC PG) pela bolsa de estudo concedida. that were the only sequences available in the GenBank. The present study brings to light several data concerning to the Brazilian avian astroviruses, allowing to realization of the others studies related to the epidemiology of this virus, theirs potential public health risks and the adoption of the control measures targeted to this agent.

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Epidemiology and clinical features of rotavirus, adenovirus, and astrovirus infections and coinfections in children with acute gastroenteritis prior to rotavirus vaccine introduction in Meerut, North India

Akdag

Gupta

Khan

et al. 2019

Journal of Medical Virology

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There are limited reports on the etiology of multiple enteric viruses causing acute gastroenteritis (AGE) in North India. In the present study we have determined the prevalence of three enteric viruses, namely rotavirus, astrovirus (AstV) and adenovirus (AdV) in a total of 312 diarrheic children (<5 years) hospitalized at Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh from August 2014 to July 2016; and results were compared with data from Delhi. The fecal samples were individually screened for group A rotavirus (RVA), AdV, and AstV using enzyme immunoassay kits. At least one viral agent was detected in 29.2% of 312 fecal specimens. RNA of rotavirus antigen‐positive samples was extracted by TRIzol method. Rotavirus G/P genotyping was performed using seminested multiplex reverse transcriptase‐polymerase chain reaction. RVA was the most predominant virus (18.3%) followed by AstV (12.5%), and AdV (9.9%). Coinfections were detected in 10.6% cases and the most common coinfection in diarrheic children was RVA combined with AstV (36.4%). Overall, the enteric viruses were found most prevalent in the 6 to 11 months age group (P = .01). Increased duration of vomiting (≥3 days) was significantly (P = .04) associated with AdV infection (61.3%) as compared with AstV (30.76%) and rotavirus (26.31%). G1P[8] was detected throughout as the most prevalent rotavirus strain (10.5%). Unusual RV strains like G2P[6] and G2P[8] were also detected. Of note G3, G4, and G12 rotavirus were detected for the first time in Meerut. This is the first report that demonstrated the important contribution of multiple enteric viruses causing AGE in young children in this part of Uttar Pradesh (Meerut).

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Nosocomial diarrhea in children: is astrovirus the leading pathogen?

Cited by 3 publications

References 8 publications

Changing pattern of prevalence, genetic diversity, and mixed infections of viruses associated with acute gastroenteritis in pediatric patients in New Delhi, India

Changing pattern of prevalence, genetic diversity, and mixed infections of viruses associated with acute gastroenteritis in pediatric patients in New Delhi, India

<b>Detecção e genotipagem de astrovírus em amostras fecais de aves de produção procedentes de diferentes criações comerciais brasileiras</b>

Epidemiology and clinical features of rotavirus, adenovirus, and astrovirus infections and coinfections in children with acute gastroenteritis prior to rotavirus vaccine introduction in Meerut, North India

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