Nosocomial infectious potency of imipenem-resistant Pseudomonas aeruginosa isolated from obstetric and gynecologic infections

Yin, Xianghua; Mikamo, Hiroshige; Tamaya, Teruhiko

doi:10.1007/s10156-002-0220-8

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Pseudomonas aeruginosa is a Gram‐negative opportunistic pathogen in humans (Yin et al . ; Colombo et al . ; Dettman et al .…”

Section: Introductionmentioning

confidence: 99%

“…Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen in humans (Yin et al 2003;Colombo et al 2013;Dettman et al 2013) and in companion animals (Authier et al 2006;Blondeau et al 2012), especially in dogs with chronic, deep pyoderma and chronic otitis externa and otitis media (Cole et al 1998;Foster and DeBoer 1998;Colombini et al 2000;Hillier et al 2006). Pseudomonas aeruginosa also causes problems for various animals in the farm environment (Wilson et al 1997;Bannerman et al 2005;Hossain et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of antibiotic and disinfectant susceptibility profiles amongPseudomonas aeruginosaveterinary isolates recovered during 1994-2003

et al. 2014

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“…Pseudomonas aeruginosa is a Gram‐negative opportunistic pathogen in humans (Yin et al . ; Colombo et al . ; Dettman et al .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of antibiotic and disinfectant susceptibility profiles amongPseudomonas aeruginosaveterinary isolates recovered during 1994-2003

et al. 2014

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“…Pseudomonas aeruginosa , an important aetiological agent of septicaemia in immunocompromised hosts, is associated with a higher fatality rate than any other Gram‐negative bacterial infection. Although antibiotic therapy is considered to be the most effective against infections caused by this micro‐organism, it is frequently ineffective because of bacterial resistance (Yin et al. 2003; Ramphal 2004).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice

et al. 2008

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Aims: The aim of the study was to evaluate the efficacy of probiotics on gut‐derived sepsis caused by Pseudomonas aeruginosa in immunocompromised mice. Methods and Results: After oral inoculation of P. aeruginosa, mice were treated with cyclophosphamide to induce leucopenia and translocation of the intestinal P. aeruginosa into blood, thereby producing gut‐derived sepsis. In this model, administration of 1 × 109 CFU of Bifidobacterium longum strain BB536 for 10 days significantly (P < 0·01) increased the survival rate compared with groups of mice administered either with Bifidobacterium breve strain ATCC 15700 or excipients contained in the probiotic bacterial powder. Administration of B. longum significantly decreased viable counts of P. aeruginosa in the liver and blood compared with other groups. Culture of intestinal contents revealed a significantly lower viable count of P. aeruginosa in the jejunum of B. longum‐treated mice compared with other groups of mice. Furthermore, in vitro data demonstrated that B. longum possessed apparently higher adherent activity to Caco‐2 cell monolayers and significantly suppressed the adherence of P. aeruginosa to the monolayers of cells compared with other groups. Conclusion: Oral administration of B. longum protects mice against gut‐derived sepsis caused by P. aeruginosa, and the effect may be due to interference of P. aeruginosa adherence to intestinal epithelial cells. Significance and Impact of this Study: This study demonstrated that oral administration of B. longum BB536 is effective to protect against opportunistic infection with drug‐resistant bacteria such as P. aeruginosa. The results suggest that probiotics may play an important role even in the immunocompromised patients.

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“…[14][15][16][17][18] Epidemiological data on these pathogens in obstetrics are scarce and old. 19 However, CPE has been reported recently as a possible cause of severe disease in pregnant women. 20 Both ways could have led to colonization, especially in the presence of poor adherence to correct screening 12 and isolation procedures.…”

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confidence: 99%

What Is the Best Initial Empirical Treatment of Suspected Sepsis in a Newborn Readmitted Soon after Discharge Home in an Era of Increased Resistance to Antibiotics? A Report of Two Cases

et al. 2016

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Background Colonization/infection by antibiotic-resistant bacteria is becoming a major threat to health care systems. Case report Two septic neonates were readmitted in our hospital few days after hospital discharge. In both of them, microbiological workup revealed an infection caused by multiresistant pathogens. Noteworthy, one baby had received intensive care management for 4 weeks, whereas the other had been vaginally delivered and sent home on his second day of life. Conclusion These cases suggest that in countries and/or hospital with high prevalence of colonization/infection by resistant pathogens in nurseries, neonatal intensive care units, and obstetric wards, the choice of initial therapy of suspected sepsis in a neonate readmitted from home soon after discharge should take into account the possibility of an infection due to a multiresistant pathogen.

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Nosocomial infectious potency of imipenem-resistant Pseudomonas aeruginosa isolated from obstetric and gynecologic infections

Cited by 4 publications

References 14 publications

Characterization of antibiotic and disinfectant susceptibility profiles amongPseudomonas aeruginosaveterinary isolates recovered during 1994-2003

Characterization of antibiotic and disinfectant susceptibility profiles amongPseudomonas aeruginosaveterinary isolates recovered during 1994-2003

Oral administration of Bifidobacterium longum prevents gut-derived Pseudomonas aeruginosa sepsis in mice

What Is the Best Initial Empirical Treatment of Suspected Sepsis in a Newborn Readmitted Soon after Discharge Home in an Era of Increased Resistance to Antibiotics? A Report of Two Cases

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