Nosocomial outbreak of Myroides odoratimimus urinary tract infection in a Tunisian hospital

Ktari, Sonia; Mnif, Basma; Koubâa, Makram; Mahjoubi, Faouzia; Jemâa, Mounir Ben; Mhiri, M.N.; Hammami, A.

doi:10.1016/j.jhin.2011.09.010

Cited by 69 publications

(86 citation statements)

References 9 publications

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“…can cause soft tissue infection (Benedetti et al, 2011), cellulitis (Bachmeyer et al, 2007), necrotizing fasciitis (Crum-Cianflone et al, 2014), ventriculitis (Macfarlane et al, 1985), and urinary tract infections (Yağci et al, 2000). M. odoratimimus even caused an outbreak of urinary tract infection in a hospital (Ktari et al, 2012).…”

Section: Antibiotic Resistance Status Of Clinical Myroides Sp Infectmentioning

confidence: 99%

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Antibiotic resistance mechanisms of Myroides sp.

Yuan

et al. 2016

J. Zhejiang Univ. Sci. B

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Bacteria of the genus Myroides (Myroides spp.) are rare opportunistic pathogens. Myroides sp. infections have been reported mainly in China. Myroides sp. is highly resistant to most available antibiotics, but the resistance mechanisms are not fully elucidated. Current strain identification methods based on biochemical traits are unable to identify strains accurately at the species level. While 16S ribosomal RNA (rRNA) gene sequencing can accurately achieve this, it fails to give information on the status and mechanisms of antibiotic resistance, because the 16S rRNA sequence contains no information on resistance genes, resistance islands or enzymes. We hypothesized that obtaining the whole genome sequence of Myroides sp., using next generation sequencing methods, would help to clarify the mechanisms of pathogenesis and antibiotic resistance, and guide antibiotic selection to treat Myroides sp. infections. As Myroides sp. can survive in hospitals and the environment, there is a risk of nosocomial infections and pandemics. For better management of Myroides sp. infections, it is imperative to apply next generation sequencing technologies to clarify the antibiotic resistance mechanisms in these bacteria.

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Section: Antibiotic Resistance Status Of Clinical Myroides Sp Infectmentioning

confidence: 99%

“…Thus, Myroides spp. are widely distributed in nature (Mammeri et al, 2002;Ktari et al, 2012;Suganthi et al, 2013;Ravindran et al, 2015).…”

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confidence: 99%

Antibiotic resistance mechanisms of Myroides sp.

Yuan

et al. 2016

J. Zhejiang Univ. Sci. B

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“…Two studies reported nosocomial outbreaks of urinary tract infections in the setting of urinary stones or cancer (Ktari et al, 2012;Yagci et al, 2000). In nosocomial infections the source is mostly unknown, however water has been suspected to carry this organism (Hugo et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Myroides spp. Causing Urinary Tract Infection in an Immunocompromised Patient: A Case Report

Thass¹,

Kumar²,

Kaur³

2018

Int.J.Curr.Microbiol.App.Sci

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A 12 year old girl presented to the paediatric OPD with complains of generalised swelling and decreased urine output for the past ten days. The swelling started from the face followed by the abdomen and limbs. The patient also had cough, difficulty in breathing and episodes of vomiting for the past 2 days. The vomiting was non-bilious and nonprojectile. There was no history of fever, pain abdomen, loose stools, burning micturition or haematuria. There was no history of headache, or any evidence of focal neurological defect. On examination her blood pressure was found to be raised. Her cardiovascular and motor system functions were found to be within normal limits. On per abdomen examination, abdomen was found to be soft and distended, no organomegaly found and bowel sounds were normal. Her haemogram was within normal limits, ANA was negative. Chest Xray showed signs of pleural effusion and pleural fluid was negative for TB by Genexpert. Her C3 and C4 complement levels were within normal limits. On urine analysis showed protein to creatinine ratio of 2.57. Urine dipstick showed-albumin (3+) and sugar (nil). Serum protein was 3.5-4 g/dl (normal: 6-8.3 g/dl) and serum albumin 1.3-1.5 g/dl (3.5-5 g/dl). Her total blood cholesterol was 912 mg/dl (normal <200 mg/dl). The patient had hypoalbuminemia, hyper albuminuria, hyperlipidemia and generalised edema, thus a presumptive diagnosis of nephrotic syndrome was made.

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“…In immunocompromised patients, Myroides may be responsible for skin infections in patients with diabetes [6,7], urinary tract infections, lung infections [8][9][10], endocarditis [11], ventriculitis [12,13], bacteremia [14] or infections of the central nervous system. Rarely, there have been reported cases of infection in immunocompetent hosts [12,13]; the described cases were associated with hepatic, renal insufficiency, malignancies or co-infections with Oerskovia turbata in alithiasic cholecystitis [15].…”

Section: Discussionmentioning

confidence: 99%