‘Not-so-minor’ stroke: Lasting psychosocial consequences of anterior cingulate cortical ischemia in the rat

Hewlett, Krista A.; Kelly, Meighan H.; Corbett, Dale

doi:10.1016/j.expneurol.2014.07.024

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…4-7), with no locomotor impairments (Fig. 4C)or bias in spontaneous alternation.Other similar studies from this lab have shown a similar lack of effect on motor function as assessed by skilled reaching and cylinder tests [33].…”

Section: Discussionmentioning

confidence: 87%

Assessing cognitive function following medial prefrontal stroke in the rat

Livingston-Thomas

Jeffers

Nguemeni

et al. 2015

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 87%

Assessing cognitive function following medial prefrontal stroke in the rat

Livingston-Thomas

Jeffers

Nguemeni

et al. 2015

Behavioural Brain Research

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“…Studies were only included if specific bregma coordinates were reported. For (A) (functions associated with Cg1/Cg2), studies included: [39,40,45,46,[56][57][58][59][60][61][62][63]; for (B) (functions associated with rodent ACC/MCC), studies included: [19, 41,42,49,54,82,83,87,[106][107][108][109][110][111][112][113][114][115][116][117][118][119][120]. Abbreviations: ACC, anterior cingulate cortex; Cg1, cingulate area 1; Cg2, cingulate area 2; MCC, midcingulate cortex.…”

Section: Trends In Neurosciencesmentioning

confidence: 99%

Where is Cingulate Cortex? A Cross-Species View

Heukelum

Mars

Guthrie

et al. 2020

Trends in Neurosciences

192

147

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To compare findings across species, neuroscience relies on cross-species homologies, particularly in terms of brain areas. For cingulate cortex, a structure implicated in behavioural adaptation and control, a homologous definition across mammals is availablebut currently not employed by most rodent researchers. The standard partitioning of rodent cingulate cortex is inconsistent with that in any other model species, including humans. Reviewing the existing literature, we show that the homologous definition better aligns results of rodent studies with those of other species, and reveals a clearer structural and functional organisation within rodent cingulate cortex itself. Based on these insights, we call for widespread adoption of the homologous nomenclature, and reinterpretation of previous studies originally based on the nonhomologous partitioning of rodent cingulate cortex.

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“…It has been demonstrated that damage to other limbic structures, such as the cingulate or parahippocampal cortex, may cause psychosocial behavioral disturbances [84] as well as deficits in spatial learning [85] and memory recognition [3, 86]. Thus, damage within different structures of the limbic system, particularly those belonging to the Papez circuit, may promote cognitive decline associated with CI.…”

Section: Neural Underpinnings Of Disrupted Plasticity Processes: Invomentioning

confidence: 99%

Altered Neural Networks in the Papez Circuit: Implications for Cognitive Dysfunction after Cerebral Ischemia

Escobar

Jackson

et al. 2019

JAD

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Cerebral ischemia remains a leading cause of mortality worldwide. Although the incidence of death has decreased over the years, surviving patients may suffer from long-term cognitive impairments and have an increased risk for dementia. Unfortunately, research aimed toward developing therapies that can improve cognitive outcomes following cerebral ischemia has proved difficult given the fact that little is known about the underlying processes involved. Nevertheless, mechanisms that disrupt neural network activity may provide valuable insight, since disturbances in both local and global networks in the brain have been associated with deficits in cognition. In this review, we suggest that abnormal neural dynamics within different brain networks may arise from disruptions in synaptic plasticity processes and circuitry after ischemia. This discussion primarily concerns disruptions in local network activity within the hippocampus and other extra-hippocampal components of the Papez circuit, given their role in memory processing. However, impaired synaptic plasticity processes and disruptions in structural and functional connections within the Papez circuit have important implications for alterations within the global network, as well. Although much work is required to establish this relationship, evidence thus far suggests there is a link. If pursued further, findings may lead toward a better understanding of how deficits in cognition arise, not only in cerebral ischemia, but in other neurological diseases as well.

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‘Not-so-minor’ stroke: Lasting psychosocial consequences of anterior cingulate cortical ischemia in the rat

Cited by 9 publications

References 49 publications

Assessing cognitive function following medial prefrontal stroke in the rat

Assessing cognitive function following medial prefrontal stroke in the rat

Where is Cingulate Cortex? A Cross-Species View

Altered Neural Networks in the Papez Circuit: Implications for Cognitive Dysfunction after Cerebral Ischemia

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