Notch Signaling in Cell–Cell Communication Pathways

Bigas, Anna; Espinosa, Lluís

doi:10.1007/s40778-016-0065-1

Cited by 19 publications

(11 citation statements)

References 69 publications

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“…Details of the 86 KEGG pathways can be found in Table S4 . The most statistically significant pathways include major pathways involved in cell differentiation (Hedgehog signaling, N = 29) 30 , cell migration (Wnt signaling, N = 114) 31 , and cell-to-cell communication (Notch signaling, N = 39) 32 .…”

Section: Resultsmentioning

confidence: 99%

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

You

Corley

Wen

et al. 2018

Sci Rep

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Keratoconus is a common degenerative corneal disease that can lead to significant visual morbidity, and both genetic and environmental factors have been implicated in its pathogenesis. We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery from keratoconus and myopia control patients, undergoing collagen cross-linking and photorefractive keratectomy, respectively. We identified major differences in keratoconus linked to cell-cell communication, cell signalling and cellular metabolism. The genes associated with the Hedgehog, Wnt and Notch1 signaling pathways were down-regulated in keratoconus. We also identified plasmolipin and Notch1 as being significantly reduced in keratoconus for both gene and protein expression (p < 0.05). Plasmolipin is a novel protein identified in human corneal epithelium, and has been demonstrated to have a key role in epithelial cell differentiation in other tissues. This study shows altered gene and protein expression of these three proteins in keratoconus, and further studies are clearly warranted to confirm the functional role of these proteins in the pathogenesis of keratoconus.

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Section: Resultsmentioning

confidence: 99%

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

You

Corley

Wen

et al. 2018

Sci Rep

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“…The Notch signaling pathway is a well‐preserved molecular mechanism that coordinates cellular events that occur within a neighboring cell community (Abdel‐Mohsen et al, 2019a, 2019b). The interaction among ligands and receptors of the Notch pathway is critical in deciding the status of Notch and the impact of any particular cellular event often induced by other signaling pathways (Bigas & Espinosa, 2016). Notch signaling was established as a key regulator of energy homeostasis that is closely correlated with glycol‐metabolism and lipid accumulation (Zhao et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Ziziphus spina‐christi (L.) fortified with Camellia sinensis mediates apoptosis, Notch‐1 signaling, and mitigates obesity‐induced non‐alcoholic fatty liver

2021

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The habit of drinking tea is highly prevalent and could be utilized to introduce more health benefits through fortification with medicinal plants. The purpose of this analysis was to assess the nutritional quality and health benefits of fortified Ziziphus tea (ZT) with green tea (GT) against obesity and non‐alcoholic fatty liver disease (NAFLD). Proximate analysis and sensory evaluation were carried out on the fortified tea. In the in vivo study, 15 SD rats were used for each group. Flow cytometry was utilized for caspase 3 analysis. ELISA was used for the detection of tumor necrosis factor‐alpha and adiponectin levels. Real‐time PCR was used to detect Notch‐1 and Hes‐1 gene expression. The composition of fortified (GT+ZT) showed a significant improvement in the nutritional value represented by the increase in overall protein, crude fat, crude fiber, ash, carbohydrate, mineral contents, and antioxidant capacity. Treatment with GT+ZT restored the disturbance in body weight, lipid profile, liver function, glucose, insulin sensitivity index, and oxidative status. It reversed the changes in TNF‐α and adiponectin levels. Their protective effects against NAFLD were indicated by the inhibition of hepatic caspase‐3 activity, suppression of Notch‐1, and Hes‐1 gene expression and amelioration of high‐fat diet (HFD)‐induced histological alterations. Collectively, our findings, elucidate the precise mechanism of fortified ZT+GT for the attenuation of obesity‐induced metabolic disorders and NAFLD via regulating lipolysis, TNF‐α, adiponectin, apoptosis, and Notch‐1 signaling pathways, and provide a foundation for an easily implemented healthy habit of drinking. Practical applications The incorporation of bioactive compounds into functional foods is a growing market. Consumer attention in well‐being has increased rapidly toward a fortified diet that provides additional health effects. The fortified (GT+ZT) tea may potentially serve as an easily implemented healthy drinking habit to prevent and manage obesity and NAFLD and reduce the risk of other diseases. Fortification with ZT improved the health‐promoting functionality of GT through the enhancement of total protein, carbohydrates, antioxidant, and mineral contents. This was reflected by their synergetic therapeutic activity in ameliorating the disturbance in obesity‐related disorders and NAFLD via regulating lipolysis, inflammation, oxidative stress, apoptosis, and Notch‐1 signaling pathways. Therefore, (GT+ZT) could be considered functional foods which attribute to functional improvement and reduction in disease risk.

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“…Concerning the overlap with Reactome pathways, the vitamin A target genes obtained from CTD are significantly enriched in signaling by NOTCH. The NOTCH signalling pathway is mainly involved in cell-to-cell communication, 45 and it plays a role in the development of most organs and tissues. 46 Other Reactome terms also have overlapping genes, even if not significant.…”

Section: Resultsmentioning

confidence: 99%

Overlap of vitamin A and vitamin D target genes with CAKUT-related processes

et al. 2021

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Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) are a group of abnormalities affecting the kidneys and their outflow tracts, which include the ureters, the bladder, and the urethra. CAKUT patients display a large clinical variability as well as a complex aetiology, as only 5% to 20% of the cases have a monogenic origin. It is thereby suspected that interactions of both genetic and environmental factors contribute to the disease. Vitamins are among the environmental factors that are considered for CAKUT aetiology. In this study, we collected vitamin A and vitamin D target genes and computed their overlap with CAKUT-related gene sets. We observed significant overlaps between vitamin A target genes and CAKUT causal genes, or with genes involved in renal system development, which indicates that an excess or deficiency of vitamin A might be relevant to a broad range of urogenital abnormalities.

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Notch Signaling in Cell–Cell Communication Pathways

Cited by 19 publications

References 69 publications

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patients

Ziziphus spina‐christi (L.) fortified with Camellia sinensis mediates apoptosis, Notch‐1 signaling, and mitigates obesity‐induced non‐alcoholic fatty liver

Overlap of vitamin A and vitamin D target genes with CAKUT-related processes

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