Notes - Derivatives of (1-Aminocyclobexyl)-methanol

Notes - Kinetics of the Acid-Catalyzed Condensation of Formaldehyde with N,N-Dimethyl-m-toluidine

“…From previous work, we expected the reaction to occur in two steps, of which the first would be rate- determining under conditions of moderate acidity. [1][2][3][4] The possibility of isolating the substituted benzyl alcohol (BA) under conditions of high acid-ity6 suggested, however, that there is an inversion of relative specific rates ki/k2 as the acidity of the medium is increased. The earlier work indicated that in the absence of excessive concentrations of formaldehyde the reaction is uncomplicated by further additions, condensation, or polymerization, or by ortho addition.…”