Notizen: Kämpferol-3-glucuronid und Quercetin-3-glucuronid, Hauptflavonoide von Euphorbia lathyris L. und ihre Trennung an acetyliertem Polyamid

Dumkow, K.

doi:10.1515/znb-1969-0323

Cited by 17 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of the common techniques for isolation and characterization of glycosides result in the loss of glucuronides, because they contain a carboxylic acid group. There have been reports (Dumow, 1969) that glucuronides are irreversibly bound to polyamide columns and cannot be isolated in this manner. However, their characterization has also been reported by just such a technique (Wagner et al, 1970).…”

Section: Glycosidementioning

confidence: 99%

Flavonol Glycosides of the Cultivated Strawberry

Ryan¹

1971

Journal of Food Science

View full text Add to dashboard Cite

SUMMARY— Alter extraction and separation by thin‐layer chromatography (TLC) on cellulose, nine flavonol glycosides were detected and purified in the fruit of strawberry from various sources. The structures of these were investigated by TLC, spectral properties and several types of hydrolysis. Four of them mere completely identified as the ‐3‐ß‐monoglucosides and ‐3‐ß‐glucuronides of quercetin and kaempferol. Three others were characterized less fully as kaempferol‐7‐monogluco‐side, a kaempferol‐7‐glucoside and an unreported quercetin‐3‐glucoside which was not the ‐3‐ß‐monoglucoside or a diglucoside. A comparison between the flavonol glycosides and anthocyanins of this fruit was made with respect to the amounts and types present.

show abstract

Section: Glycosidementioning

confidence: 99%

Flavonol Glycosides of the Cultivated Strawberry

Ryan¹

1971

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…Table 1 gives a summary of the isolated flavonoids, their structures, occurrence and their pharmacological effect. Some flavonoids such as rhamnetin-3-α-arabinofuranoside ( 80) from E. amygdaloides, kaempferol-3-glucuronide ( 36) from E. lathyris [52,57] 60) from E. ebracteolata were reported for the first time by Xin et al [59]. This showed the structural diversity of Euphorbia flavonoids.…”

Section: Flavonoids Isolated From Euphorbia Speciesmentioning

confidence: 95%

“…In contrast, E. mygdaloides [51], E. paralias [52], E. stenoclada [53], E. altotibetic [51,54], E. allepica [51,55] and E. magalanta [51] were the least-investigated species, having the least number of isolated flavonoids (n = 1). Others include E. helioscopia (n = 7) [56], E. lathyris (n = 3) [57], E. humifusa [58], E. ebracteolata (n = 4) [59] and E. lunulata [60]. Future studies should therefore be directed on these species, as they remain a promising source of bioactive constituents.…”

Section: Flavonoids Isolated From Euphorbia Speciesmentioning

confidence: 99%

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

et al. 2021

View full text Add to dashboard Cite

Plants of the genus Euphorbia are widely distributed across temperate, tropical and subtropical regions of South America, Asia and Africa with established Ayurvedic, Chinese and Malay ethnomedical records. The present review reports the isolation, occurrence, phytochemistry, biological properties, therapeutic potential and structure–activity relationship of Euphorbia flavonoids for the period covering 2000–2020, while identifying potential areas for future studies aimed at development of new therapeutic agents from these plants. The findings suggest that the extracts and isolated flavonoids possess anticancer, antiproliferative, antimalarial, antibacterial, anti-venom, anti-inflammatory, anti-hepatitis and antioxidant properties and have different mechanisms of action against cancer cells. Of the investigated species, over 80 different types of flavonoids have been isolated to date. Most of the isolated flavonoids were flavonols and comprised simple O-substitution patterns, C-methylation and prenylation. Others had a glycoside, glycosidic linkages and a carbohydrate attached at either C-3 or C-7, and were designated as d-glucose, l-rhamnose or glucorhamnose. The structure–activity relationship studies showed that methylation of the hydroxyl groups on C-3 or C-7 reduces the activities while glycosylation loses the activity and that the parent skeletal structure is essential in retaining the activity. These constituents can therefore offer potential alternative scaffolds towards development of new Euphorbia-based therapeutic agents.

show abstract

“…[79] It is well-known that Euphorbia species characterized by the diversity of phenolic metabolites like flavonoids, lignans and coumarins. [62] The flavonol glucuronides, (1, 2), were obtained from E. lathyris, [80] E. retusa and E. sanctae-catharinae. [81] Regarding lignan derivatives, the compound (41) was isolated from E. quinquecostata [31] while similar lignans were isolated from E. usambarica [71] and E. neriifolia [82] that supported the chemotaxonomic significance of these compounds.…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

Integration of LC/MS, NMR and Molecular Docking for Profiling of Bioactive Diterpenes from Euphorbia mauritanica L. with in Vitro Anti‐SARS‐CoV‐2 Activity

Essa¹,

El‐Hawary

Kubacy³

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

In spite of tremendous efforts exerted in the management of COVID-19, the absence of specific treatments and the prevalence of delayed and long-term complications termed post-COVID syndrome still urged all concerned researchers to develop a potent inhibitor of SARS-Cov-2. The hydromethanolic extracts of different parts of E. mauritanica were in vitro screened for anti-SARS-Cov-2 activity. Then, using an integrated strategy of LC/MS/MS, molecular networking and NMR, the chemical profile of the active extract was determined. To determine the optimum target for these compounds, docking experiments of the active extract's identified compounds were conducted at several viral targets. The leaves extract showed the best inhibitory effect with IC 50 8.231 � 0.04 μg/ml. The jatrophane diterpenes were provisionally annotated as the primary metabolites of the bioactive leaves extract based on multiplex of LC/MS/MS, molecular network, and NMR. In silico studies revealed the potentiality of the compounds in the most active extract to 3CLpro, where compound 20 showed the best binding affinity. Further attention should be paid to the isolation of various jatrophane diterpenes from Euphorbia and evaluating their effects on SARS-Cov-2 and its molecular targets.

show abstract

Notizen: Kämpferol-3-glucuronid und Quercetin-3-glucuronid, Hauptflavonoide von Euphorbia lathyris L. und ihre Trennung an acetyliertem Polyamid

Cited by 17 publications

References 0 publications

Flavonol Glycosides of the Cultivated Strawberry

Flavonol Glycosides of the Cultivated Strawberry

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

Integration of LC/MS, NMR and Molecular Docking for Profiling of Bioactive Diterpenes from Euphorbia mauritanica L. with in Vitro Anti‐SARS‐CoV‐2 Activity

Contact Info

Product

Resources

About