Notizen zur Synthese von 2‐Aminophenylsulfonen

Abstract

Syntheses of some Alkyl, Cycloalkyl and AryI2-Aminophenyl Sulfones SummarySyntheses of the alkyl, cycloalkyl and aryl 2-aminophenyl sulfones 10 were achieved by oxidation of the corresponding 2-nitrophenyl sulfides 7 to the 2-nitrophenyl sulfones 9 followed by ethanolic BPchamp-reduction. The sulfides 7 in turn were obtained either by reactions of 2-nitro-thiophenol (8) with the appropriate alkyl and cycloalkyl halides or of 2-chloro-nitrobenzene (5) with the relevant thiols. Condensation of 2-nitrobenzenesulfinic acid (3) with bromoacetic acid in aqueous alkaline solution led -presumably via 2-nitrophenylsulfonylacetic acid (4) -to methyl 2 nitrophenyl sulfone (l), reduction of which gave 2-aminophenyl methyl sulfone (2). Treatment of 2-aminothiophenol (11) with t-butyl alcohol in aqueous sulfuric acid gave 2-aminophenyl t-butyl sulfide (12), which was acetylated to o-t-butylthio-acetanilide (13). Oxidation of the latter to o-t-butylsulfonylacetanilide (14) followed by hydrolysis led to 2-aminophenyl t-butyl sulfone (15). Als Methode zur Herstellung von

Preparation, Structure and Reactivity of Polynuclear Gold(I) Phosphanyl Alkanethiolates

“…C 4 H 9 AuS (286.15): calcd. C 16.79, H 3.17; found C 16.64, H 3.20. Neopentanethiol was prepared by a literature procedure [21] Method A: Neopentanethiol (0.327 g, 3.14 mmol) was added dropwise to an aqueous solution of H[AuCl 4 ] (29.34 wt.-% Au) (0.676 g, 1 mmol Au) in EtOH (2.6 mL). An exothermic reaction occurred with the formation of a brown solid that turned white in 30 min.…”

Addressing Hydrogen Bonding Motifs by Suited Substitution of Thioureas

“…All chemicals were purchased from Fluka, Sigma Aldrich, Acros Organics, abcr and Merck. All primary amines were synthesized according to literature or analogue to them 48–50. The solvents were purified by standard literature procedures 24…”

N,N’-Bis(2-mercaptophenyl)propane-1,3-diamine as a new organic ligand of the N2S2 type and its coordination compound with nickel(II)

“…39 Water (25 mL) and concen trated sulfuric acid (34 mL) were placed into a 100 mL round bottom flask equipped with a dropping funnel, thermometer, and magnetic stirring bar, then tert butanol (11 mL, 1.2•10 -1 mol) was added at 0 °C, followed by a slow addition of 2 ami nobenzenethiol (10 g, 8.0•10 -2 mol) over 40 min at the same temperature. The reaction mixture was stirred for 1 h at 0 °C and poured into a saturated aq.…”