Nottingham Prognostic index (NPI) – a Simple Predictive Tool for Operable Breast Cancer

Thangjam, Dhanabir; Agrawal, Sanjit Kumar; Chatterjee, Sanjoy; Ahmed, Rosina

doi:10.1016/j.clon.2016.10.017

Cited by 2 publications

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“…Our findings correlated well with the studies of Bhagat et al 3 and Thiyagarajan et al 16 with lymph node involvement seen in 53.44% and 53.3% of the cases respectively. However, Ahmed et al 19 , Nisa et al 18 and Siadati et al 8 21 , Agarwal et al 22 , Thangjam et al 23 and Shukla et al 24 We observed that positivity for estrogen receptor decreased as the grades increased. Maximum percentage of ER positivity was observed in cases with grade I (75%) which declined in grade II (44.11%) followed by grade III (11.11%).…”

Section: Discussionmentioning

confidence: 58%

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Juneja¹,

Agarwal²,

Agarwal³

et al. 2019

IJCMR

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Introduction: Breast carcinoma is the most common cancer among women in both developing and developed countries. It needs alarming attention because it causes high morbidity and mortality. There is a need to understand the initiation and progression of breast cancer on hormonal, cellular and molecular basis which forms the platform for designing of targeted therapy. This study was intended to find correlation between the expression of Estrogen receptor, Progesterone receptor and Human Epidermal Growth Factor Receptor-2 with histological grade in cases of carcinoma breast.

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Section: Discussionmentioning

confidence: 58%

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Juneja¹,

Agarwal²,

Agarwal³

et al. 2019

IJCMR

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“…According to D'Fredita et al, Fong et al and Thangiam et al NPI is simple clinicopathological prognostic tool which not only gives accurate prediction of prognosis but also offer guidance for administration of adjuvant therapies. [19][20][21] Thus we found the validity of 'NPI as a prognostic tool in breast carcinoma 'is very high.…”

Section: Axillary Lymph Node Scorementioning

confidence: 98%

Nottingham Prognostic Index: Useful tool to assess outcome inpatients of breast carcinoma

Randale¹,

Parate²

2020

ACHR

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Breast cancer has been ranked number one cancer among the Indian females surpassing the incidence of cervical cancer. Multiple clinico-pathological-molecular prognostic factors are available in decision making about potentially suitable treatment options for breast cancer. Among all, Nottingham Prognostic Index (NPI) is the most powerful integrated index. Present study aimed to evaluate the significance of NPI in prognosis of operable breast cancer patients. Materials and Methods: This longitudinal (Descriptive) study was carried on 60 female patients of operable breast carcinoma at tertiary care centre in central India. Results: Two patients from good prognostic group (NPI≤3.4) (30%) had metastasis to bone & CNS. F rom moderate prognostic group ((NPI 3.4 -5.4) (50%) , one patient had recurrence at previous surgical scar site and 3 patients had metastasis to liver, lung and supraclavicular lymph node each. However the worst outcome was found in patients from poor prognostic group (NPI > 5.4) (10%). Five patients from poor prognostic group had metastasis in liver, bone, CNS and lung with two patients had simultaneous metastasis in liver & bone. Four patients from poor prognostic group had death within two and half year s of primary diagnosis. Out of 60 patients, 34 patients had a follow up of more than 1000 days, so were included in statistical analysis of survival based on Cox Proportional Hazard Model. Among 7 variables, NPI was found to be statistically most significant with p value 0.001 Conclusion: Estimation of NPI is the powerful and reproducible index for assessing prognosis in patients with operable breast cancer in advanced resources deprived institute. Main strength of NPI lies in the fact that it is based on relatively simple data which can be provided in routine histopathology report of carcinoma breast.

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Nottingham Prognostic index (NPI) – a Simple Predictive Tool for Operable Breast Cancer

Cited by 2 publications

References 0 publications

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Nottingham Prognostic Index: Useful tool to assess outcome inpatients of breast carcinoma

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