Novas evidências sobre o valor diagnóstico da reação de imunofluorescência indireta e reação intradérmica de hipersensibilidade tardia na infecção humana por Leishmania (L.) infantum chagasi na Amazônia, Brasil

Barbosa, R. N.; Corrêa, Zuila de Jesus Coelho; Jesus, Roseli Conceição dos Santos de; Everdosa, Domingas Ribeiro; Brandão, João A; Coelho, Raimundo Negrão; Monteiro, A. J; Machado, R. S; Luz, João Batista Palheta da; Martins, Antônio F. P; Brandão, Roberto Carlos Feitosa; Lima, José Aprígio Nunes; Barata, Iorlando da Rocha; Pinheiro, Maria Sueli Barros; Leão, Edna de Freitas; Silva, Fábio Márcio Medeiros da; Silva, Maria das Graças Soares da; Campos, Marliane Batista; Souza, Álvaro Nogueira de; Lainson, Ralph; Sílveira, Fernando Tobias

doi:10.5123/s2176-62232010000100006

Cited by 3 publications

(4 citation statements)

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“…Importantly, the high infection rate detected by MST reveals a large contingent of individuals with cellular immune resistance to L. chagasi infection, i.e., the findings indicate that many infected individuals in an endemic area are resistant to the disease 24 .…”

Section: Discussionmentioning

confidence: 93%

“…The positive rate for infection was considerably higher for MST than for ELISA. According to Barbosa et al 24 , in endemic areas, the high infection rate in individuals with a positive cellular response indicates that the majority of cases present a brief period of humoral response (ELISA+), followed by rapid MST conversion, which remains positive for a more prolonged period. The higher MST rate as compared to ELISA may be explained by re-infections, since persons in endemic areas are permanently exposed to bites by infected sand flies 25,26 .…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis

et al. 2012

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This study analyzed factors associated with asymptomatic Leishmania chagasi infection in family members and neighbors of patients with visceral leishmaniasis (VL). A cross-sectional study was conducted with 361 individuals in the counties comprising Ilha de São Luís (São Luís Island) in Maranhão State, Brazil. The Montenegro skin test (MST) and serology by enzyme-linked immunosorbent assay (ELISA) were performed to detect infection. Odds ratios (OR) and prevalence ratios (PR) and their 95% confidence intervals (95%CI) were estimated by multilevel logistic regression and Poisson regression, respectively. The rates of positive reactions were 71.3% for MST and 9.7% for ELISA. The variable associated with infection according to MST was living in the same household as the index case (PR = 1.36; 95%CI: 1.03-1.78). According to ELISA, the statistically significant variables were: living in the county of Raposa (OR = 3.56; 95%CI: 1.24-10.19) and living in the same household as the index case (OR = 2.70; 95%CI: 1.19-6.08). Family members of individuals with LV are at increased risk of infection. Priority control measures should target these families.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis

et al. 2012

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“…It is important to note that although 23.4% of the municipalities in Pernambuco did not report VL cases during the study period, this does not mean that these municipalities were PLOS NEGLECTED TROPICAL DISEASES disease free. Indeed, it is well known that symptomatic cases are only a small percentage among those infected [34]. Furthermore, aside from the failure in the diagnosis of the disease, failure in the notification system has also been reported in Brazil due to incomplete and/or poorly filled information [35].…”

Section: Detection Of Vl Casesmentioning

confidence: 99%

Patterns and drivers of Human Visceral Leishmaniasis in Pernambuco (Brazil) from 2007 to 2018

et al. 2023

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Visceral leishmaniasis (VL) is the second most common protozoosis that affects people around the world. The aim of this study is to understand how environmental and socioeconomic factors, as well as VL control and surveillance interventions, influence the spread and detection of VL cases in Pernambuco state (Brazil). A novel model was developed to analyze cases of VL between 2007 and 2018, enabling the quantification of the association of these variables with two processes: the probability of “invasion” (emergence of new cases) at municipalities by VL, and the probability of detecting cases not reported in municipalities that have already been invaded. Pernambuco state identified 1,410 cases of VL between 2007 and 2018, with an average of 128 cases per year and average incidence of 1.28/100 thousand people. These cases were distributed in 77.1% (142/184) of the municipalities, and 54.8% (773/1,410) of them were autochthonous. Our model reveals that the proportion of agriculture was positively associated with VL invasion probability. We also find that municipalities that are closer to notification centers and/or that have received technical training and support tend to have higher detection rates of VL cases. Taken together, these results suggest that a municipality with almost no agriculture and that received technical training, located close to a notification center, is unlikely to be invaded if no cases have ever been detected. On the other hand, a municipality that is far from the notification center, with no technical training, with a large agricultural area might have already been invaded but the surveillance system might have routinely failed to detect VL cases due to low detection probability. By disentangling the processes of invasion and detection, we were able to generate insights that are likely to be useful for the strategic allocation of VL prevention and control interventions.

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“…A detecção de anticorpos IgG anti rK 39 tem se mostrado bastante sensível e específico para LV. 242,246 A utilização da rk 39 baseados em métodos ELISA apresentou uma sensibilidade de em plataformas imunocromotográficas, que permitem execução simples e interpretação visual das reações, que apresentam valores de sensibilidade e especificidade que variam de 67 a 100% e de 59% a 100%, respectivamente. A avaliação desses testes apresentam resultados variáveis de acordo com a área geográfica do estudo, produto e da metodologia.…”

Section: Testes Sorológicosunclassified

Análise epidemiológica da Leishmaniose visceral humana no Brasil: contribuição as políticas de controle

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serem o alicerce necessário e aplausos em minhas conquistas.vi "Por vezes sentimos que aquilo que fazemos não é senão uma gota de água no mar. Mas o mar seria menor se lhe faltasse uma gota" (Madre Teresa de Calcutá)vii AGRADECIMENTOSAgradeço a todos que de alguma maneira contribuíram para elaboração deste trabalho:Ao meu orientador, Prof. Dr. Vitor Laerte Pinto Júnior, pelos valiosos ensinamentos, paciência e dedicação no decorrer da elaboração da tese. A ele, minha admiração, por ser um exemplo de profissionalismo.À Diretoria de Atenção Primária-DIRAPS do Hospital Regional de Sobradinho, em especial ao Dr. Cleiton e a Enfermeira Iris Silva, por oportunizar a execução de parte deste trabalho.Às equipes da estratégia Saúde da Família-ESF, da região administrativa da Fercal -DF: comunidades do Engenho Velho,Queima Lençol e Rua do Mato, pelo apoio técnico no trabalho de campo.À Drª Isabele Barbieri Santos, pelas discussões e incentivo na elaboração deste trabalho.Ao Prof. Dr. Cesar Carranza-Tamayo, pelas discussões e apoio ao trabalho.À Drª Denise Furlanetto, pelo apoio e incentivo na reta final deste trabalho. À CAPES, pelo financiamento, com a concessão de bolsa de estudos.Aos membros da banca, pela cordialidade, de terem aceitado participar da discussão da minha tese.Às minhas amigas, Norma Paes Santos e Cristiane Citadin, pela amizade verdadeira de sempre.Aos meus pais, pelo apoio incondicional e por sempre ter valorizado a minha formação.Aos meus irmãos, Pedro José de Moura Júnior e Alexandre Fragoso de Moura pelo apoio necessário.Ao meu esposo, Marcus Vinícius Lane de Abreu, pelo companheirismo. Amo-te! Ao meu filho e príncipe, Arthur Fragoso de Abreu, que apesar de pequeno, é luz em muitos momentos e de uma compreensão admirável.Por fim, a Deus pela oportunidade de executar este trabalho, vencer obstáculos e superar os desafios.

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Novas evidências sobre o valor diagnóstico da reação de imunofluorescência indireta e reação intradérmica de hipersensibilidade tardia na infecção humana por Leishmania (L.) infantum chagasi na Amazônia, Brasil

Cited by 3 publications

References 22 publications

Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis

Factors associated with asymptomatic infection in family members and neighbors of patients with visceral leishmaniasis

Patterns and drivers of Human Visceral Leishmaniasis in Pernambuco (Brazil) from 2007 to 2018

Análise epidemiológica da Leishmaniose visceral humana no Brasil: contribuição as políticas de controle

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