Novel 12-Deoxy-16-hydroxyphorbol Diesters Isolated from the Seed Oil of Jatropha curcas

Haas, W.; Sterk, H.; Mittelbach, Martin

doi:10.1021/np020060d

Cited by 169 publications

(128 citation statements)

References 20 publications

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“…Phorbol esters contain tetracyclic diterpenoid skeleton (tiglian) and two fatty acids [28]. Little information about the biosynthetic pathway of phorbol ester has been elucidated.…”

Section: In Silico Analysis Of Casbene Synthase Among Euphorbiaceae Pmentioning

confidence: 99%

Reverse Transcription-PCR analysis of geranylgeranyl diphosphate synthase (JcGGPPS) in Jatropha curcas L. and in silico analysis of Casbene Synthase (JcCS) among Euphorbiaceae

Jadid

Mardika

Nurhidayati

et al. 2016

AIP Conference Proceedings

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Abstract. Recently, Euphorbiaceae have attracted much attention for their potential uses in biodiesel production. Their seeds have been well known as the principal resource for oil production. The seed-derived oil content ranged from 28 % to 39 % by dry weight for all Euphorbiaceae species. Meanwhile, their seed also possesses relatively high protein content, ranged from 22 % to 35 %, making them a new alternative for livestock animal feed resources. Nevertheless, the development of this new animal feed resource is limited to the toxicity of the seeds. Its toxicity is mainly caused by the presence of anti-nutrient agents and toxins, such as curcin, trypsin inhibitor and phorbol ester (PE). The later is known to be tetracyclic diterpenes, which represents the primary toxic substances in one of the Euphorbiaceae plants, Jatropha curcas L. To date, little is known about the biosynthesis of these toxic substances. This research aims to analyze the expression of JcGGPPS gene encoding the geranylgeranyl diphosphate synthase involved in the production of the primary precursor for diterpenoid substances. In addition, the phylogram was presented to show the Euphorbiaceae Casbene Synthase (CS). The RT-PCR analysis showed that JcGGPPS is expressed both in seeds and leaves of J. curcas. Meanwhile, in silico analysis of six Euphorbiaceae species showed that CS from Euphorbia esula, Euphorbia resinifera, Euphorbia peplus and Euphorbia fischeriana are highly identical. In addition, CS from J. curcas derives from a different origin than other Euphorbiaceae plants.

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“…Phorbol esters contain tetracyclic diterpenoid skeleton (tiglian) and two fatty acids [28]. Little information about the biosynthetic pathway of phorbol ester has been elucidated.…”

Section: In Silico Analysis Of Casbene Synthase Among Euphorbiaceae Pmentioning

confidence: 99%

Reverse Transcription-PCR analysis of geranylgeranyl diphosphate synthase (JcGGPPS) in Jatropha curcas L. and in silico analysis of Casbene Synthase (JcCS) among Euphorbiaceae

Jadid

Mardika

Nurhidayati

et al. 2016

AIP Conference Proceedings

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show abstract

“…They are generally found in plant species of the families Euphorbiaceae and Thymelaeceae. Recently, various forms of phorbol esters have been isolated from J. curcas aerial parts and seed oil [10][11][12]. Generally, due to toxicity it causes tumor promotion, skin inflammation, activation of blood platelets, tissue damage, lymphocyte mitogenesis, stimulation of degranulation in neutrophils in living cells and prostaglandin production [8,13].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Anti-Inflammatory Activity of Press Cake of Jatropha curcas

Tripathi¹,

Sharma²

2016

Appli Micro Open Access

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Several compounds present in fruits as Polyphenol, are able to kill or inhibit the growth of microorganisms. These properties are relevant mainly in tropical areas, as Amazonian region where infectious are highly prevalent. Therefore, this study investigated the antimicrobial activity of Jatropha curcas seed cake against microorganisms. The results showed antibacterial effect of Jatropha curcas seed cake methanolic extracts on two Gram-positive bacteria and Gram-negative bacteria. Effect of Jatropha curcas seed cake on Superoxide and nitric oxide production was also estimated in macrophage cells. This result suggests its anti-inflammatory and antibacterial potential of the herb, which could be due to the bio-active principles which are anti-inflammatory and antibacterial in nature. The present study, therefore emphasizes the use of Jatropha curcas seeds as an anti-inflammatory and antibacterial drug against macrophage cells and bacteria respectively.

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“…The phorbol esters molecules are tetracyclic diterpenoids with a tigliane skeletal structure [5]. These authors isolated six different types of PE of Jatropha curcas and all of these compounds possess the same diterpene core, namely, 12-deoxy-16-hydroxyphorbol.…”

Section: Introductionmentioning

confidence: 99%

Technical and Economic Evaluation of Phorbol Esters Extraction from Jatropha curcas Seed Cake using Supercritical Carbon Dioxide

Pereira¹

2015

J Adv Chem Eng

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Novel 12-Deoxy-16-hydroxyphorbol Diesters Isolated from the Seed Oil of Jatropha curcas

Cited by 169 publications

References 20 publications

Reverse Transcription-PCR analysis of geranylgeranyl diphosphate synthase (JcGGPPS) in Jatropha curcas L. and in silico analysis of Casbene Synthase (JcCS) among Euphorbiaceae

Reverse Transcription-PCR analysis of geranylgeranyl diphosphate synthase (JcGGPPS) in Jatropha curcas L. and in silico analysis of Casbene Synthase (JcCS) among Euphorbiaceae

Antimicrobial and Anti-Inflammatory Activity of Press Cake of Jatropha curcas

Technical and Economic Evaluation of Phorbol Esters Extraction from Jatropha curcas Seed Cake using Supercritical Carbon Dioxide

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