Novel 3-alkanoyl/aroyl/heteroaroyl-2H-chromene-2-thiones: Synthesis and evaluation of their antioxidant activities

Crystal structure of 3-amino-8-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C21H16N2O2

“…In recent years, they have attracted considerable attention due to their antimicrobial [2,3], antileishmanial [4][5][6][7][8][9], anticancer [10][11][12][13][14][15], antiproliferative [22], antioxidant [16][17][18], hypertensive [14], antitumor [19][20][21] effects and activities, as well as proving potentially useful in the treatment of Alzheimer's disease [23] and schizophrenia disorder [24].…”

Crystal structure of 3-amino-9-methoxy-1-phenyl-1H-benzo[f]chromene-2-carbonitrile, C21H16N2O2

“…Chromene and benzochromene derivatives have attracted considerable interest owing to their biological and pharmaceutical activities such as antibacterial [1][2][3], antifungal [4][5][6], vascular-disrupting [7], antioxidant [8,9], anticancer [10][11][12][13], estrogenic anticoagulant and antispasmolytic [14], antileishmanial [15], antiproliferative and apoptosis inducing [16][17][18][19].…”

Molecular Docking and in Vitro Antileishmanial Evaluation of Chromene-2-thione Analogues

“…15 We have selected our title compounds 2H-chromene-2-thione and benzo[f ]chromene-2-thione for development and assessment against L. donovani. The compounds have already been reported to exhibit profound antioxidant activities 16 but have not previously been tested against any Leishmania species.…”