Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs

Szeto, Betsy; Aksit, Aykut; Valentini, Chris; Yu, Michelle; Werth, Emily G.; Goeta, Shahar; Tang, Chuanning; Brown, Lewis M.; Olson, Elizabeth S.; Kysar, Jeffrey W.; Lalwani, Anil K.

doi:10.1016/j.heares.2020.108141

Cited by 61 publications

(63 citation statements)

References 38 publications

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“…Two-photon polymerization is a 3D lithography additive manufacturing technology. This process has been largely implemented for the production of conventional microneedles [95][96][97][98][99][100][101][102][103][104][105][106][107] and BMNs. 13,108,109 This method is flexible, highly precise and time-effective.…”

Section: Two-photon Polymerizationmentioning

confidence: 99%

Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Makvandi

Maleki

Shabani

et al. 2022

Matter

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Nature contains abundant systems that can significantly alter their structures and properties to adapt to the surrounding environment. Through natural selection and unceasing evolution, hierarchical architectures and sophisticated strategies have been created by nature to achieve optimally adapted materials for biomedical applications. The development of microneedles has advanced to the next generation of bioinspired microneedles, with the goal of improving functions such as amelioration of mechanical properties and tissue adhesion. The biomimetic designs and structures of microneedles are highlighted in the present review. This is followed by an in-depth discussion of the fabrication approaches from molding techniques to 3D and 4D printing. The medical applications of bioinspired microneedles, including drug delivery, regenerative medicine, biopsy sampling and biosensing, are also discussed. Lastly, future opportunities and challenges with respect to clinical translation are also deliberated.

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Section: Two-photon Polymerizationmentioning

confidence: 99%

Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Makvandi

Maleki

Shabani

et al. 2022

Matter

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“…Moussi et al also demonstrated a single fabrication process using TPP 3DP that allows for producing hollow MNs directly connected to a reservoir, making them suitable for implanting inside the body, transdermal sampling, or drug delivery applications ( Figure 5 b) [ 143 ]. Szeto et al demonstrated that TPP 3D printed hollow MNs can facilitate the intracochlear sampling of perilymph [ 148 ]. Cordeiro et al described an approach to fabricate high-quality MN array master templates using TPP 3DP.…”

Section: Fabrication Of Microneedles Using 3d Printing Technologiesmentioning

confidence: 99%

“…Biocompatible and FDA-approved materials were used in CLIP 3DP MN development, including polyethylene glycol dimethacrylate (PEG) and polycaprolactone trimethacrylate with TPO (diphenyl (2,4,6-trimethyl-benzoyl-)phosphine oxide) [ 139 , 140 ]. Organically modified ceramic (Ormocer ® ) [ 61 , 147 ] or acrylic are commonly used in TPP MN fabrication [ 109 , 148 ].…”

Section: Parameters Affecting the Mechanical Properties Of 3d Printed Microneedlesmentioning

confidence: 99%

“…The laser-based writing systems are capable of printing MN arrays of the same design with high degrees of consistency [ 21 ]. Therefore, MNs with various shapes have been produced by SLA [ 33 , 45 , 64 , 96 , 125 , 126 ], DLP [ 124 , 130 , 137 ], LCD [ 138 ], CLIP [ 139 , 140 ], TPP [ 109 , 142 , 143 , 144 , 148 ], DLMS [ 156 ], and SLM methods [ 158 ] ( Table 2 ).…”

Section: Parameters Affecting the Mechanical Properties Of 3d Printed Microneedlesmentioning

confidence: 99%

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3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

et al. 2021

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Microneedles (MNs) represent the concept of attractive, minimally invasive puncture devices of micron-sized dimensions that penetrate the skin painlessly and thus facilitate the transdermal administration of a wide range of active substances. MNs have been manufactured by a variety of production technologies, from a range of materials, but most of these manufacturing methods are time-consuming and expensive for screening new designs and making any modifications. Additive manufacturing (AM) has become one of the most revolutionary tools in the pharmaceutical field, with its unique ability to manufacture personalized dosage forms and patient-specific medical devices such as MNs. This review aims to summarize various 3D printing technologies that can produce MNs from digital models in a single step, including a survey on their benefits and drawbacks. In addition, this paper highlights current research in the field of 3D printed MN-assisted transdermal drug delivery systems and analyzes parameters affecting the mechanical properties of 3D printed MNs. The current regulatory framework associated with 3D printed MNs as well as different methods for the analysis and evaluation of 3D printed MN properties are outlined.

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“…In contrast, Additive Manufacturing (AM) offers a much more convenient way of manufacturing due to the following reasons: a) HMNs are first designed with Computer Aided Design (CAD) software and designs can be saved as .stl files and be modified if necessary, b) manufacture is a single step procedure in which layers of the printing material are successively deposited on a building platform with no use of extra tooling and c) machinery required (computer and 3D-printer) is quite simple, which in fact can result in establishing small production units all over the world including developing countries [7]. HMNs have been produced mainly by means of vat polymerization methods (VPM) namely stereolithography (SLA) [8][9][10] and 2-photon polymerization (2-PP) [11][12][13][14][15]. Other methods include Fused Filament Fabrication (FFF) [16,17], and Selective Laser Micro Melting (SLμΜ) [18].…”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of Hollow Microneedles for Insulin Delivery

Xenikakis¹,

Tsongas²,

Tzimtzimis³

et al. 2021

IJMMT

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Microneedles (MN) are miniature devices capable of perforating painlessly stratum corneum and delivering active ingredients in the inner epidermal layers. Hollow microneedles (HMNs) are highly detailed objects due to their internal microchannels and thus, their fabrication with Additive Manufacturing (AM) is a challenging task. Vat polymerization techniques provide a sufficient accuracy for such microstructures. Differentiated from other approaches where stereolithography and 2-photon polymerization were adopted, this paper presents the 3D-printing of HMNs purposed for insulin delivery, using the more economic Liquid Crystal Display (LCD) method. First, different geometries (hexagon, square pyramid, beveled) were 3D printed with constant height and varying curing time, printing angle and layer resolution. Quality features in each case were captured with optical and scanning electron microscopy (SEM). The most promising geometry was found to be the beveled one due to the more refined tip area and the feasibility of non-clogged microchannel formation. Among printing parameters, printing angle proved to be the most influential, as it affects resin flow phenomenon during printing process. Lastly, optimized HMN geometry was the beveled configuration, where the average height was measured 900μm, 3D printing angle was set at -45°, the curing time was 10s per layer and the optimal layer height was 30μm.

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Novel 3D-printed hollow microneedles facilitate safe, reliable, and informative sampling of perilymph from guinea pigs

Cited by 61 publications

References 38 publications

Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

3D Printing—A “Touch-Button” Approach to Manufacture Microneedles for Transdermal Drug Delivery

Additive Manufacturing of Hollow Microneedles for Insulin Delivery

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