Novel ACE inhibitory peptides derived from bighead carp (Aristichthys nobilis) hydrolysates: Screening, inhibition mechanisms and the bioconjugation effect with graphene oxide

Chen, Mengting; Wang, Lan; Zheng, Changliang; Ma, Aimin; Hu, Kai; Xiang, Aoli; Sun, Zhida; Xie, Bijun; Xiong, Guangquan; Liu, Shi; Chen, Sheng; Wu, Wenjin

doi:10.1016/j.fbio.2023.102399

Cited by 21 publications

(12 citation statements)

References 37 publications

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“…Incorporating bioactive peptides into functional foods can contribute to disease prevention and management by harnessing their specific biological activities. For instance, bioactive peptides such as ACE inhibitors have been shown to effectively regulate blood pressure by inhibiting ACE activity, making them promising candidates for functional foods targeting hypertension (Chen et al., 2023). Moreover, bioactive peptides with antioxidant properties can combat oxidative stress, a key factor in chronic diseases, when incorporated into functional foods (Mardani et al., 2023).…”

Section: Application Of Bioactive Peptidementioning

confidence: 99%

“…EDC/NHS chemistry is a common method for conjugating PEG to peptides or proteins through carboxylate groups. Chen et al (2023) utilized EDC/NHS chemistry to couple graphene oxide with a peptide, resulting in a coupling product. The ACE-inhibitory activity of the coupled product exhibited a significant increase of 19% compared to that of the pure peptide.…”

Section: Pegylationmentioning

confidence: 99%

“…Remarkably, bioactive peptides and proteins demonstrate properties akin to hormones or drugs, thereby playing a beneficial role in metabolic processes and contributing to human well‐being. Bioactive peptides are categorized based on their distinct biological activities, including but not limited to antihypertensive (Chen et al., 2023; Uluko et al., 2014), antioxidant (Alahyaribeik & Ullah, 2020; Alizadeh & Aliakbarlu, 2020; Ashraf et al., 2020), antibacterial (Aguilar‐Toala et al., 2020; Alizadeh & Aliakbarlu, 2020), immunomodulatory (Zhang, Huang, et al., 2019c), anticancer (Chan et al., 2011; Ma et al., 2022), hypocholesterolemic (Ashraf et al., 2020), and mineral‐binding peptides (Luo et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

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Enhancing activity of food protein‐derived peptides: An overview of pretreatment, preparation, and modification methods

Chen,

Ma,

Sun

et al. 2023

Comp Rev Food Sci Food Safe

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Food protein‐derived peptides have garnered considerable attention due to their potential bioactivities and functional properties. However, the limited activity poses a challenge in effective utilization aspects. To overcome this hurdle, various methods have been explored to enhance the activity of these peptides. This comprehensive review offers an extensive overview of pretreatment, preparation methods, and modification strategies employed to augment the activity of food protein‐derived peptides. Additionally, it encompasses a discussion on the current status and future prospects of bioactive peptide applications. The review also addresses the standardization of mass production processes and safety considerations for bioactive peptides while examining the future challenges and opportunities associated with these compounds. This comprehensive review serves as a valuable guide for researchers in the food industry, offering insights and recommendations to optimize the production process of bioactive peptides.

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Section: Application Of Bioactive Peptidementioning

confidence: 99%

Section: Pegylationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing activity of food protein‐derived peptides: An overview of pretreatment, preparation, and modification methods

Chen,

Ma,

Sun

et al. 2023

Comp Rev Food Sci Food Safe

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“…Peptide YIRLHF identied from bighead carp protein also showed competitive inhibitory kinetics and offered high restraining ability on ACE (IC 50 : 121.90 mmol L −1 ). 41 3.5.3 The binding mode of EASPKPV to zinc ion. Zinc tetrahedral coordination, consisting of a zinc ion attached to three residues (His383, His387, and Glu411), plays an important role in the catalytic function of ACE.…”

Section: Safety Analysismentioning

confidence: 99%

“…10,39 Oligopeptides such as LSMSFPPF, VPKIPPP, and PPSEPTKL (derived from ginkgo seed and bighead carp), containing a high content of Pro, also exhibited excellent stability against gastrointestinal enzymic digestion. 21,41 However, the effect of gastrointestinal enzymes on the structure of EASPKPV should be investigated in future studies.…”

Section: Stability Against Gastrointestinal Digestionmentioning

confidence: 99%

Isolation, virtual screening, action mechanisms, chelation with zinc ions, and stability of ACE-inhibitory peptides from ginkgo seed globulin

Gao,

Liu,

Wang

2023

RSC Adv.

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Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin–angiotensin–aldosterone system and intestinal microbiota

Chen,

Huan,

et al. 2024

J Sci Food Agric

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BACKGROUNDHypertension is a chronic disease with high morbidity and mortality. Previously, we screened a walnut meal peptide FDWLR (PEP) with significant angiotensin‐converting enzyme inhibitory activity. The present study further investigated the anti‐hypertensive effects of PEP in vivo using spontaneously hypertensive rats.RESULTSThe results indicated that PEP reduced blood pressure and the indices in the renin–angiotensin–aldosterone system (RAAS) including angiotensin‐converting enzyme (ACE) (decreased by 15.36%), angiotensin II (Ang II) (decreased by 31.56%), angiotensinogen (AGT) (decreased by 58.84%) and aldosterone (ALD) (decreased by 18.27%), whereas NO levels increased by 54.96%. The pathological analysis showed that PEP relieved cardiac and renal damage. PEP also alleviated oxidative stress, inflammation and fibrosis in the heart and kidney. Mechanistically, PEP mitigated cardiac and renal damage by simultaneously regulating ACE‐Ang II‐AT1R and the ACE2‐Ang (1–7)‐MAS axis. Additionally, PEP increased the levels of short chain fatty acids by 224.16% and improved gut microbiota by increasing the abundance of Prevotella, Phascolarctobacterium, Clostridium_sensu_stricto and Bifidobacterium, at the same time as decreasing Bacteroides and Alistipes abundances.CONCLUSIONThis study indicated that PEP prevented hypertension and associated heart and kidney damage by modulating the RAAS system and gut microbiota, which is valuable in guiding future development and optimal utilization of walnut meal. © 2024 Society of Chemical Industry.

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Novel ACE inhibitory peptides derived from bighead carp (Aristichthys nobilis) hydrolysates: Screening, inhibition mechanisms and the bioconjugation effect with graphene oxide

Cited by 21 publications

References 37 publications

Enhancing activity of food protein‐derived peptides: An overview of pretreatment, preparation, and modification methods

Enhancing activity of food protein‐derived peptides: An overview of pretreatment, preparation, and modification methods

Isolation, virtual screening, action mechanisms, chelation with zinc ions, and stability of ACE-inhibitory peptides from ginkgo seed globulin

Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin–angiotensin–aldosterone system and intestinal microbiota

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