Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus

El-Lebedy, Dalia; Ibrahim, Alshaymaa A.; Ashmawy, Ingy

doi:10.1016/j.dsx.2018.04.025

Cited by 36 publications

(19 citation statements)

References 40 publications

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“…Additionally, diabetic patients with CVD had significantly lower serum irisin than non-CVD patients [ 69 ]. Low levels of serum irisin have been associated with 1.6 times increased risk of CVD incidence in T2DM patients [ 70 ].…”

Section: Mechanisms Leading To T2dm and Pathophysiologymentioning

confidence: 99%

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Pathophysiology of Type 2 Diabetes Mellitus

Galicia-García

Benito‐Vicente

Jebari

et al. 2020

IJMS

1,737

822

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Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM.

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Section: Mechanisms Leading To T2dm and Pathophysiologymentioning

confidence: 99%

“…It has been shown that T2DM patients have higher serum vaspin levels than healthy controls. Higher vaspin levels are associated with a 1.7-fold increased risk of CVD [ 70 ]. High vaspin is also associated with increased severity of coronary artery disease [ 286 ].…”

Section: T2dm Outcomes/complications: Cardiovascular Riskmentioning

confidence: 99%

Pathophysiology of Type 2 Diabetes Mellitus

Galicia-García

Benito‐Vicente

Jebari

et al. 2020

IJMS

1,737

822

View full text Add to dashboard Cite

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“…Over the past three decades, obesity has been a worldwide epidemic and a serious threat to human health for the steady rising of global obesity rate as well as no-declined prevalence rates[3]. Accumulating evidence suggests that overweight/obesity has been identified as an independent risk factor for chronic diseases, including metabolic syndrome, cardiovascular disease, and diabetes mellitus, leading to a negative effect on health-related quality of life and a heavy pressure on the health care system[4-6]. Hence, identification of overweight/obesity-oriented factors that are potential biomarkers that could be used to predict obesity and related complications is important.…”

Section: Introductionmentioning

confidence: 99%

Relationship between circulating irisin levels and overweight/obesity: A meta-analysis

Jia¹,

Fan²,

Wei³

et al. 2019

WJCC

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BACKGROUND Currently, the findings about irisin as a novel myokine related to obesity are inconsistent in overweight/obese people. To our knowledge, no systematic analysis has been conducted to evaluate the relationship between irisin levels and overweight/obesity. AIM To evaluate the association between circulating irisin levels and overweight/obesity. METHODS The Cochrane Library, MEDLINE, SCOPUS, and the ISI Web of Science were searched to retrieve all of the studies associated with circulating irisin levels and overweight/obesity. Standard mean difference values and 95% confidence intervals (CI) were estimated and pooled using meta-analysis methodology. RESULTS A total of 18 studies were included in our meta-analysis containing 1005 cases and 1242 controls. Our analysis showed that the circulating irisin level in overweight/obese people was higher than that in overall healthy controls (random effects MD = 0.63; 95%CI: 0.22-1.05; P = 0.003). In the subgroup analysis by ethnicity, the irisin level was higher in overweight/obesity people than that in controls in Africa (random effects MD = 3.41; 95%CI: 1.23-5.59; P < 0.05) but not in European, Asian, or American populations. In addition, in a subgroup analysis by age, the results showed that obese children exhibited a higher irisin level than controls (random effects MD = 0.86; 95%CI: 0.28-1.43; P < 0.05). CONCLUSION This meta-analysis provides evidence that circulating irisin is higher in obese individuals compared to healthy controls and it is important to identify the relationship between circulating irisin levels and overweight/obesity in predicting overweight/obesity.

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“…In the present study, the data showed that the serum vaspin level was positively associated with DR and VTDR. Similarly, one study reported that vaspin levels were significantly higher in patients with cardiovascular disease than in in patients without cardiovascular disease, and elevated vaspin levels were associated with a 1.7-fold increased risk of cardiovascular disease in type 2 diabetes patients (P = 0.001) 40 . However, one study found that low vaspin levels were a risk factor for diabetic nephropathy in type 2 diabetes mellitus patients 41 , whereas another study showed that vaspin levels did not change within the early stages in patients with diabetic nephropathy 42 .…”

Section: Discussionmentioning

confidence: 91%

Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus

Yang

Huang

Gai

et al. 2020

J of Diabetes Invest

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Aims/Introduction: Vaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision-threatening DR. Materials and Methods: This was a cross-sectional single-center observational study from December 2018 to September 2019. We evaluated circulating serum levels of vaspin in 372 participants with type 2 diabetes. DR was screened through detailed ocular examination. DR patients were also divided two groups: vision-threatening DR and non-visionthreatening DR. The relationship between vaspin and DR was investigated by univariate and multivariate logistic regression analyses, and the results are shown as odds ratios with 95% confidence intervals. Results: The vaspin serum levels of 372 patients were obtained, with a median value of 1.50 ng/mL (interquartile range 0.94-2.18 ng/mL). The median age of those patients was 53 years (interquartile range 44-62 years), and 44.4% were women. Patients with DR and VDTR had significantly increased vaspin serum levels (P < 0.001 and P < 0.001). A multivariable regression model found that patients with high levels of vaspin were approximately 1.85-fold (odds ratio for per unit increase 1.85, 95% confidence interval 1.43-2.55; P < 0.001) more likely to experience DR, and 3.76-fold (odds ratio for per unit increase 3.76, 95% confidence interval 2.05-6.55; P < 0.001) more likely to experience VTDR. The predictive value of vaspin was stronger in women than in men. Conclusion: Higher vaspin serum levels were associated with an increased risk of DR and VDTR in patients with type 2 diabetes, which showed that vaspin is an important indicator factor for DR.

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Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus

Cited by 36 publications

References 40 publications

Pathophysiology of Type 2 Diabetes Mellitus

Pathophysiology of Type 2 Diabetes Mellitus

Relationship between circulating irisin levels and overweight/obesity: A meta-analysis

Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus

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