2014
DOI: 10.4330/wjc.v6.i6.434
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Novel adjunctive treatments of myocardial infarction

Abstract: Myocardial infarction is a major cause of death and disability worldwide and myocardial infarct size is a major determinant of prognosis. Early and successful restoration of myocardial reperfusion following an ischemic event is the most effective strategy to reduce final infarct size and improve clinical outcome, but reperfusion may induce further myocardial damage itself. Development of adjunctive therapies to limit myocardial reperfusion injury beyond opening of the coronary artery gains increasing attention… Show more

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Cited by 21 publications
(13 citation statements)
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“…Ischemic preconditioning has been demonstrated in models of cardiac and neural tissue and has been shown to enhance stem cell survival by providing resistance to necrosis and lending functional benefits to heart, brain, and kidney models after transplantation . The fundamentals of this concept may have applications in transplant and cardiac surgery, in the management of acute coronary syndromes and stroke, and in athletic training and performance . Although OSA has been associated with long‐term cardiovascular morbidity and mortality, the intermittent hypoxemia OSA patients experience could actually improve their ability to survive clinical deterioration in the short‐term (ie, during a hospitalization).…”
Section: Discussionmentioning
confidence: 99%
“…Ischemic preconditioning has been demonstrated in models of cardiac and neural tissue and has been shown to enhance stem cell survival by providing resistance to necrosis and lending functional benefits to heart, brain, and kidney models after transplantation . The fundamentals of this concept may have applications in transplant and cardiac surgery, in the management of acute coronary syndromes and stroke, and in athletic training and performance . Although OSA has been associated with long‐term cardiovascular morbidity and mortality, the intermittent hypoxemia OSA patients experience could actually improve their ability to survive clinical deterioration in the short‐term (ie, during a hospitalization).…”
Section: Discussionmentioning
confidence: 99%
“…Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia–reperfusion injury . Previous proof‐of‐concept clinical studies using RIC before (preconditioning) or during (perconditioning) a major ischemic event have demonstrated improvements in surrogate markers of ischemia (eg, increased myocardial salvage and reduced infarct size) in a variety of clinical scenarios including acute STEMI, elective PCI, and coronary artery bypass grafting (CABG) surgery . In addition, in patients with STEMI, RIC before PCI has been shown to reduce the incidence of contrast‐induced acute kidney injury and has prevented acute kidney injury in patients undergoing cardiopulmonary bypass–assisted cardiac surgery …”
Section: Introductionmentioning
confidence: 99%
“…Despite the progress of medicine and therapeutic strategies, ischemic cardiovascular disease, which is associated with progressive heart failure, arrhythmias and sudden death, remains the most life-threatening health problem worldwide [1,2]. The potential severity to patients emphasizes the importance of novel and effective therapeutic strategies for ischemia cardiomyopathy.…”
Section: Introductionmentioning
confidence: 99%