Novel AFM Nanoprobes

Espinosa, Horacio D.; Moldovan, N.; Kim, K.-H.

doi:10.1007/978-3-540-37321-6_3

Cited by 4 publications

(3 citation statements)

References 121 publications

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“…Nanoscale patterning of biofunctional and biological compounds (especially proteins) on solid surfaces is always challenging and is difficult to implement using the standard photolithography or e-beam techniques. The available tools optimized for biofunctional writing are micro- and nanopipettes, , which offer the process resolution essentially at the micrometer scale. In our proof-of-principle experiments, we have confirmed rapid chemical writing also with -functionalized thiol inks for obtaining protein patterns in a bioinert matrix (see Figure S12 for details).…”

Section: Discussionmentioning

confidence: 99%

Scanning Probe-Directed Assembly and Rapid Chemical Writing Using Nanoscopic Flow of Phospholipids

Navikas

Gavutis

Rakickas

et al. 2019

ACS Appl. Mater. Interfaces

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Nanofluidic systems offer a huge potential for discovery of new molecular transport and chemical phenomena that can be employed for future technologies. Herein, we report on the transport behavior of surface-reactive compounds in a nanometer-scale flow of phospholipids from a scanning probe. We have investigated microscopic deposit formation on polycrystalline gold by lithographic printing and writing of 1,2-dioleoyl-sn-glycero-3-phosphocholine and eicosanethiol mixtures, with the latter compound being a model case for self-assembled monolayers (SAMs). By analyzing the ink transport rates, we found that the transfer of thiols was fully controlled by the fluid lipid matrix allowing to achieve a certain jetting regime, i.e., transport rates previously not reported in dip-pen nanolithography (DPN) studies on surface-reactive, SAM-forming molecules. Such a transport behavior deviated significantly from the so-called molecular diffusion models, and it was most obvious at the high writing speeds, close to 100 μm s–1. Moreover, the combined data from imaging ellipsometry, scanning electron microscopy, atomic force microscopy (AFM), and spectroscopy revealed a rapid and efficient ink phase separation occurring in the AFM tip-gold contact zone. The force curve analysis indicated formation of a mixed ink meniscus behaving as a self-organizing liquid. Based on our data, it has to be considered as one of the co-acting mechanisms driving the surface reactions and self-assembly under such highly nonequilibrium, crowded environment conditions. The results of the present study significantly extend the capabilities of DPN using standard AFM instrumentation: in the writing regime, the patterning speed was already comparable to that achievable by using electron beam systems. We demonstrate that lipid flow-controlled chemical patterning process is directly applicable for rapid prototyping of solid-state devices having mesoscopic features as well as for biomolecular architectures.

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Section: Discussionmentioning

confidence: 99%

Scanning Probe-Directed Assembly and Rapid Chemical Writing Using Nanoscopic Flow of Phospholipids

Navikas

Gavutis

Rakickas

et al. 2019

ACS Appl. Mater. Interfaces

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“…Nanofountain probe chips are batch fabricated on silicon wafers [23][24][25][26] and have cantilever probes that can be optimized for stiffness, tip shape, and size by modifications to the fabrication process. As described elsewhere, [23][24][25][26] the fabrication process starts with silicon on insulator wafers and involves several oxidation, lithography, etching, and deposition steps. The final nanofountain probe (NFP) chip is composed of silicon, silicon oxide, and silicon nitride.…”

Section: Nanofountain Probementioning

confidence: 99%

Microfluidic Parallel Patterning and Cellular Delivery of Molecules with a Nanofountain Probe

et al. 2014

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“…Dispensing mechanism for different probes. (a) DPN with diffusive molecular dispensing; (b) Tips with nozzle (Nanoscale Dispensing (NADIS), Scanning Ion Pipette (SIP), Nanofountain Pen (NFPen), Bioplume) perform non-diffusive liquid dispensing; (c) NFProbe also performs diffusive molecular dispensing with liquid source very close to the tip[117].…”

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confidence: 99%

Scanning Probe Microscope-Based Fluid Dispensing

et al. 2014

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Advances in micro and nano fabrication technologies have enabled fabrication of smaller and more sensitive devices for applications not only in solid-state physics but also in medicine and biology. The demand for devices that can precisely transport material, specifically fluids are continuously increasing. Therefore, integration of various technologies with numerous functionalities in one single device is important. Scanning probe microscope (SPM) is one such device that has evolved from atomic force microscope for imaging to a variety of microscopes by integrating different physical and chemical mechanisms. In this article, we review a particular class of SPM devices that are suited for fluid dispensing. We review their fabrication methods, fluid-pumping mechanisms, real-time monitoring of dispensing, physics of dispensing, and droplet characterization. Some of the examples where these probes have already been applied are also described. Finally, we conclude with an outlook and future scope for these devices where femtolitre or smaller volumes of liquid handling are needed.

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Novel AFM Nanoprobes

Cited by 4 publications

References 121 publications

Scanning Probe-Directed Assembly and Rapid Chemical Writing Using Nanoscopic Flow of Phospholipids

Scanning Probe-Directed Assembly and Rapid Chemical Writing Using Nanoscopic Flow of Phospholipids

Microfluidic Parallel Patterning and Cellular Delivery of Molecules with a Nanofountain Probe

Scanning Probe Microscope-Based Fluid Dispensing

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