Novel AgCa and AgCaLa alloys for Fe-based bioresorbable implants with adapted degradation

Krüger, Jan Tobias; Hoyer, Kay-Peter; Filor, Viviane; Pramanik, Sudipta; Kietzmann, Manfred; Meißner, Jessica; Schaper, Mirko

doi:10.1016/j.jallcom.2021.159544

Cited by 7 publications

(21 citation statements)

References 36 publications

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“…The AgCaLa phases contain 75.8 wt.-% Ag, 10.6 wt.-% Ca, 5.4 wt.-% La, 5.2 wt.-% Mn, and 3.9 wt.-% O. A detailed characterization of the LBM-processed materials and conventionally processed AgCaLa alloy has been carried out by Krüger et al [ 41 , 63 , 64 ]. In the following, the samples are designated as FeMn, FeMnAg, and FeMnAgCaLa.…”

Section: Methodsmentioning

confidence: 99%

“…Due to the immiscibility of silver (Ag) with Fe in the liquid and solid states, Ag phases can exist inside an unchanged FeMn matrix. Additionally, Ag is biocompatible and has antibacterial properties [ 31 , 39 , 40 , 41 ]. Reports in the literature confirm an increased degradation rate due to the modification with Ag [ 22 , 31 , 35 , 39 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

“…The replacement of pure Ag with a completely degradable Ag alloy is an approach to prevent such consequences. Such alloy enables the degradation of Ag phases after the matrix, while their electrochemical potential is high enough to enhance the anodic dissolution of the FeMn matrix [ 41 , 52 , 53 ]. To the best of the authors’ knowledge, this study is the first to report on the modification of FeMn with a degradable Ag alloy, enabling a residue-free dissolution.…”

Section: Introductionmentioning

confidence: 99%

“…The adjustment of the Ag release through alloying is therefore purposeful. A degradable Ag alloy containing calcium (Ca) and lanthanum (La) (AgCaLa) developed by Krüger et al [ 41 ] is proven to be suitable for modifying FeMn. Ca is a necessary trace element, and La is successfully investigated as an alloying element of degradable Mg alloys, although the uptake should be strictly limited [ 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

“…By the modification of the raw material and the LBM process, the chemical composition and the morphology of the Ag and AgCaLa phases are adaptable [ 22 , 62 , 63 , 64 ]. The raw material for the AgCaLa phases is obtained by conventional alloying and subsequent gas atomization, whereas the final structure and chemical composition of the AgCaLa inside the FeMn matrix are influenced by the LBM process [ 41 , 64 ].…”

Section: Introductionmentioning

confidence: 99%

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FeMn with Phases of a Degradable Ag Alloy for Residue-Free and Adapted Bioresorbability

Krüger

Hoyer²,

Huang³

et al. 2022

JFB

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The development of bioresorbable materials for temporary implantation enables progress in medical technology. Iron (Fe)-based degradable materials are biocompatible and exhibit good mechanical properties, but their degradation rate is low. Aside from alloying with Manganese (Mn), the creation of phases with high electrochemical potential such as silver (Ag) phases to cause the anodic dissolution of FeMn is promising. However, to enable residue-free dissolution, the Ag needs to be modified. This concern is addressed, as FeMn modified with a degradable Ag-Calcium-Lanthanum (AgCaLa) alloy is investigated. The electrochemical properties and the degradation behavior are determined via a static immersion test. The local differences in electrochemical potential increase the degradation rate (low pH values), and the formation of gaps around the Ag phases (neutral pH values) demonstrates the benefit of the strategy. Nevertheless, the formation of corrosion-inhibiting layers avoids an increased degradation rate under a neutral pH value. The complete bioresorption of the material is possible since the phases of the degradable AgCaLa alloy dissolve after the FeMn matrix. Cell viability tests reveal biocompatibility, and the antibacterial activity of the degradation supernatant is observed. Thus, FeMn modified with degradable AgCaLa phases is promising as a bioresorbable material if corrosion-inhibiting layers can be diminished.

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Section: Methodsmentioning

confidence: 99%