2019
DOI: 10.1016/j.athoracsur.2018.11.074
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Novel Alaska Pollock Gelatin Sealant Shows High Adhesive Quality and Conformability

Abstract: Background. Air leakage still remains a major problem in lung resection despite the introduction of surgical sealants. We have developed a novel sealant based on hydrophobically modified Alaska pollock-derived gelatin (ApGltn), which showed high adhesive quality in vitro. In this study, we evaluated the adhesive quality and conformability of our ApGltn sealant compared with a fibrin sealant.Methods. The adhesive quality of the sealants was evaluated using excised porcine lungs with ventilation. Pleural defects… Show more

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Cited by 13 publications
(19 citation statements)
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“…Yamaoka et al validated the burst strength of ApGltn and fibrin sealants using the air leak model of a porcine lung. 22 The burst pressure of the ApGltn sealant was significantly higher than that of fibrin Fig. 5.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…Yamaoka et al validated the burst strength of ApGltn and fibrin sealants using the air leak model of a porcine lung. 22 The burst pressure of the ApGltn sealant was significantly higher than that of fibrin Fig. 5.…”
Section: Discussionmentioning
confidence: 87%
“…In thoracic surgery, when the ApGltn sealant was applied to a rat lung defect model and to a porcine model, an inflammatory reaction was not observed at the bonding site. 22 Mizuno and Taguchi demonstrated that the ApGltn sealant promoted cell migration and acted as a scaffold for tissue migration. 29 Because it is composed of gelatin, this sealant does not prevent tissue regeneration.…”
Section: Discussionmentioning
confidence: 99%
“…Liquid ApGltn sealant has a stronger breaking strength than brin sealant [14][15][16]22 . Taguchi et al demonstrated that the burst strength of the ApGltn sealant was 11.6 times higher than that of a brin sealant in a burst porcine aorta model (341 vs. 29 mm Hg) 14 .…”
Section: Discussionmentioning
confidence: 99%
“…We have developed a surgical adhesive consisting of alkyl groups-modified Alaska pollock-derived gelatin (ApGltn) and a PEG-based crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate (4S-PEG). [15][16][17][18][19][20][21][22][23] Introduced alkyl groups effectively enhanced adhesion strength on the tissue surfaces when the degree of substitution (DS) of alkyl groups was ≈10 mol%. [15,21] However, cured adhesives swelled over 200% after immersion in saline.…”
Section: Introductionmentioning
confidence: 99%