Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer

Baghbani, Fatemeh; Moztarzadeh, Fathollah; Mohandesi, Jamshid Aghazadeh; Yazdian, Fatemeh; Mokhtari‐Dizaji, Manijhe

doi:10.1016/j.ijbiomac.2016.09.008

Cited by 43 publications

(24 citation statements)

References 43 publications

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“…Another option that can be used is alginate, which is a natural polymer derived from the brown seaweed and has been expansively scrutinized for its potential uses in the biomedical field because of its several favorable characteristics, such as low cost of manufacture, harmonious nature, less harmfulness, and easy gelling in response to the addition of divalent cations [ 58 , 59 ]. Baghbani et al [ 60 ] prepared perfluorohexane (PFH) nanodroplets stabilized with alginate to drive doxorubicin and then evaluated their sensitivity to ultrasound and imaging as well as their therapeutic properties. Further found that the ultrasound-facilitated treatment with PFH nanodroplets loaded with doxorubicin exhibited promising positive responses in the breast cancer rat models.…”

Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

“…Further found that the ultrasound-facilitated treatment with PFH nanodroplets loaded with doxorubicin exhibited promising positive responses in the breast cancer rat models. The efficacy was characterized by the deterioration of the tumor [ 60 ]. In another study, Podgorna et al [ 61 ] prepared gadolinium (GdNG) containing nanogels for hydrophilic drug loading and to enable screening by MRI.…”

Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

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Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

Section: Nano Based Drug Delivery Systemsmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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“…Baghbani et al 25,26 illustrated that using a low‐frequency US at kHz range induced more inertial cavitation than a high‐frequency US. Maximum collapsing of bubbles occurs when dual or multi‐frequency US is utilized 27 .…”

Section: Discussionmentioning

confidence: 99%

The effect of dual‐frequency ultrasound waves on B16F10 melanoma cells: Sonodynamic therapy using nanoliposomes containing methylene blue

Adelnia

Mokhtari‐Dizaji

Hoseinkhani

et al. 2020

Skin Research and Technology

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Background We investigated the effect of dual‐frequency sonication on the viability of B16F10 melanoma cells in the presence of methylene blue (MB) encapsulated in nanoliposomes. Methods Treatment protocols were studied: sonication groups (40 kHz, 1 MHz and dual‐frequency), the same sonication groups with nanoliposomes containing MB, MB free and nanoliposomes containing MB groups, and so sham and control groups. The nanoliposomes were prepared by the lipid film hydration method. The cell viability of the different treatment groups was evaluated by the MTT assay. Results The dual‐frequency protocols caused higher viability losses compared to the kHz and MHz sonications (P < .05). In presence of the nanoliposomes containing MB, dual frequency led to 6% and 3% viability for 600 and 1200 seconds, respectively, while the corresponding values were 10% and 4% for the 40 kHz protocols and 22% and 9% for the 1 MHz, as compared to the control group (100%). The result of KI dosimetry showed that the cavitation activity of the dual‐frequency protocol was about 1.23, as compared to sonication at 40 kHz and 1 MHz. Conclusion Enhancement of inertial cavitation induction by dual‐frequency sonication may be the primary effective mechanism, which causes increased sonochemical processes and drug release from nanocarriers.

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“…Whereas nanodroplets are usually composed of perfluorocarbon (PFC) and coated materials. They are stable in the blood stream, showing much greater potential as drug carriers [86][87][88]. When exposed to ultrasound at targeted site, the PFC nanodroplets undergo an instant phase transition into gas bubbles.…”

Section: Nanobubbles and Nanodropletsmentioning

confidence: 99%

Ultrasound-responsive polymer-based drug delivery systems

Wei

Cornel

2021

Drug Deliv. and Transl. Res.

108

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Ultrasound-responsive polymeric materials have received a tremendous amount of attention from scientists for several decades. Compared to other stimuli-responsive materials (such as UV-, thermal-, and pH-responsive materials), these smart materials are more applicable since they allow more efficient drug delivery and targeted treatment by fairly non-invasive means. This review describes the recent advances of such ultrasound-responsive polymer-based drug delivery systems and illustrates various applications. More specifically, the mechanism of ultrasound-induced drug delivery, typical formulations, and biomedical applications (tumor therapy, disruption of blood-brain barrier, fighting infectious diseases, transdermal drug delivery, and enhanced thrombolysis) are summarized. Finally, a perspective on the future research directions for the development of ultrasound-responsive polymeric materials to facilitate a clinical translation is given.

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Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer

Cited by 43 publications

References 43 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

The effect of dual‐frequency ultrasound waves on B16F10 melanoma cells: Sonodynamic therapy using nanoliposomes containing methylene blue

Ultrasound-responsive polymer-based drug delivery systems

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