Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents

Li, Gen; Obul, Mamateli; Zhao, Jiaheng; Liu, Ge-yu; Lü, Wei; Aisa, Haji Akber

doi:10.1016/j.bmcl.2019.08.009

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…They had comparable activity as the reference drug ribavirin in inhibiting influenza B virus. Therefore, compound 25 showed the potential to develop new broad-spectrum anti-influenza compounds(see Table 4 [24] ). Compound TC 50 [a] (μg/ mL) Against influenza A Against influenza B IC 50 [b] (μg/ mL) SI [c] IC 50 [b] (μg/ mL) SI [c] - [e] [a]50 % cytotoxic concentration.…”

Section: -Substituted Rupestonic Acid Derivativesmentioning

confidence: 99%

“…In 2019, inspired by the primary research and the indispensable role of the acetamido group in anti-influenza drugs, such as oseltamivir, zanamivir, and peramivir, in binding to active pockets, Li et al [24] introduced several amides to the 2position of rupestonic acid. This improved its anti-viral activity against both influenza A and B.…”

Section: -Substituted Rupestonic Acid Derivativesmentioning

confidence: 99%

“…Data sharing is not applicable to this article as no new data were created or analyzed in this study. [24], G. Li, Bioorg. Med.…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…They had comparable activity as the reference drug ribavirin in inhibiting influenza B virus. Therefore, compound 25 showed the potential to develop new broad‐spectrum anti‐influenza compounds(see Table 4 [24] ).…”

Section: Development Of Rupestonic Acid and Its Derivativesmentioning

confidence: 99%

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Development and Structural Modifications of Rupestonic Acid Derivatives as Novel Anti‐Influenza Agents: A Mini Review of The Last 10 Years

et al. 2022

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Artemisia rupestris L. is one of the therapeutic choices to cure influenza and concomitant infections in China. Rupestonic acid is the main active ingredient of this herbal remedy and has activity against the influenza virus. To find a potential lead compound, more than 300 rupestonic derivatives have been synthesized and assayed in vitro against influenza A and B viruses. This systematic review was therefore aimed at summarizing the rupestonic acid derivatives and their anti-influenza activity studied in the last decade. www.chemistryselect.org

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Section: -Substituted Rupestonic Acid Derivativesmentioning

confidence: 99%

Section: -Substituted Rupestonic Acid Derivativesmentioning

confidence: 99%

“…Data sharing is not applicable to this article as no new data were created or analyzed in this study. [24], G. Li, Bioorg. Med.…”

Section: Conflict Of Interestmentioning

confidence: 99%

Section: Development Of Rupestonic Acid and Its Derivativesmentioning

confidence: 99%

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Development and Structural Modifications of Rupestonic Acid Derivatives as Novel Anti‐Influenza Agents: A Mini Review of The Last 10 Years

et al. 2022

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Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids

Malico

Calzini

Gayen

et al. 2020

Journal of Industrial Microbiology and Biotechnology

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Isoprenoids are a large class of natural products with myriad applications as bioactive and commercial compounds. Their diverse structures are derived from the biosynthetic assembly and tailoring of their scaffolds, ultimately constructed from two C5 hemiterpene building blocks. The modular logic of these platforms can be harnessed to improve titers of valuable isoprenoids in diverse hosts and to produce new-to-nature compounds. Often, this process is facilitated by the substrate or product promiscuity of the component enzymes, which can be leveraged to produce novel isoprenoids. To complement rational enhancements and even re-programming of isoprenoid biosynthesis, high-throughput approaches that rely on searching through large enzymatic libraries are being developed. This review summarizes recent advances and strategies related to isoprenoid synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis, focusing on the past 5 years. Emerging applications of cell-free biosynthesis and high-throughput tools are included that culminate in a discussion of the future outlook and perspective of isoprenoid biosynthetic engineering.

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Synthesis and Antiviral Activity of New Derivatives of Rupestonic Acid

et al. 2021

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Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents

Cited by 6 publications

References 17 publications

Development and Structural Modifications of Rupestonic Acid Derivatives as Novel Anti‐Influenza Agents: A Mini Review of The Last 10 Years

Development and Structural Modifications of Rupestonic Acid Derivatives as Novel Anti‐Influenza Agents: A Mini Review of The Last 10 Years

Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids

Synthesis and Antiviral Activity of New Derivatives of Rupestonic Acid

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