Synthesis and Antiviral Activity of New Derivatives of Rupestonic Acid

Development and Structural Modifications of Rupestonic Acid Derivatives as Novel Anti‐Influenza Agents: A Mini Review of The Last 10 Years

“…In 2021, A series of 20 new derivatives of rupestonic acid were synthesized by Chen at el [25] via Davis oxidation and their antiviral activity against influenza A virus (H3N2) was tested. Several compounds were showed obvious antiviral activity against influenza A virus.…”

Xinazolin Alkaloidlarining Tiofenli Analoglari: 2-N(alkil, Aril)-Tieno[2,3-D]pirimidinonlarning Sintezi Va Modifikasiyasi

“…5 analoglari [9,10] istiqbolli sinf birikmalari sifatida e'tirof etilmoqda. Kondensirlangan pirimidinlarning kimyosi va amaliy ahamiyati, jumladan keng ko'lamli biologik faolligi turli davlatlarning olimlari e'tiborini tortib kelmoqda [11]. So'nggi yillarda pirimidin xalqasining turli geteroxalqalar bilan kondensirlangan hosilalari [12], masalan: purinlar, pteridinlar, xinazolinlar, piridopirimidinlar, pirimidoazepinlar, furo-va pirrolopirimidinlar, tiyenopirimidinlar, ularning sintezi va kimyoviy o'zgarishlari haqida keng ko'lamda chop etilayotgan ma'lumotlar ham bu sinf birikmalarining muhimligini tasdiqlaydi [13][14][15][16]3,[17][18][19][20][21][22].…”

“…2-Amino-4-asetonil-5-izopropiltiofen-3-karbon kislotasi nitrilini (6) chumoli yoki sirka kislotada 6 soat qizdirilganda tegishli 2-N(metil)-tiyeno [2,3-d]pirimidin-4-onlar (7) hosil bo'ladi [29]: R=H, CH 3 2-Aminotiofen-3-karbon kislota amidlari (8,9) formamid bilan kondensasiyalanganda 70% unum bilan tegishli tiyeno [2,3-d]pirimidin-4-onlar (10,11) hosil bo'lgan. Olingan mahsulotlar (10,11) metansulfonilxlorid (MsCl) yoki benzolsulfonilxloridlar bilan piridinda o'zaro ta'sirlashganda tegishli metil- (12) yoki fenilsulfonatlar (13) olingan [30]:…”

“…В последние годы в фармакологии перспективным классом соединений признаны тиофеновые аналоги хиназолиновых алкалоидов [9,10]. Химия и практическое значение конденсированных пиримидинов, в том числе их широкомасштабная биологическая активность, привлекли внимание ученых разных стран [11]. В последние годы опубликовано большое количество информации о производных пиримидина, конденсированных с различными гетероциклами [12], таких как: пурины, птеридины, хиназолины, пиридопиримидины, пиримидоазепины, фуро-и пирролопиримидины, тиенопиримидины, их синтезе и химических превращениях.…”

“…In recent years, thiophene analogs of quinazoline alkaloids have been recognized as a promising class of compounds in pharmacology [9,10]. The chemistry and practical importance of condensed pyrimidines, including their large-scale biological activity, have attracted the attention of scientists from different countries [11]. In recent years, much information has been published about pyrimidine derivatives condensed with various heterocycles [12], such as: purines, pteridines, quinazolines, pyridopyrimidines, pyrimidoazepines, furo-and pyrrolopyrimidines, thienopyrimidines, their synthesis and chemical transformations.…”