Novel amphiphilic glucose-responsive modified starch micelles for insulin delivery

Wen, Ning; Gao, Chunmei; Lü, Shaoyu; Xu, Xiubin; Bai, Xiao; Wu, Can; Ning, Piao; Zhang, Shaofei; Liu, Mingzhu

doi:10.1039/c7ra08291f

Cited by 24 publications

(9 citation statements)

References 60 publications

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“…When the glucose concentration was 1 g/L, the size of the micelles was basically unchanged, and the insulin was released inertly. When the glucose concentration was 5 g/L, the micelles completely disintegrated, and the insulin was released rapidly (Wen et al., 2017). Tan et al.…”

Section: Stimuli‐responsive Starch‐based Nanoparticlesmentioning

confidence: 99%

“…The [3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyl tetrazolium bromide] (MTT) assays and hemolysis studies both confirmed that the glucose‐sensitive dialdehyde starch micelles (PEG‐DAS‐APBA‐Cou) had low cytotoxic activity to A549 cells and low blood toxicity. Introducing 7‐hydroxycoumarin‐4‐acetic acid may decrease the pKa of the micelles, and the starch backbone mainly enhanced its biodegradable behavior (Wen et al., 2017). Chen et al.…”

Section: Digestibility and Toxicity Of Starch‐based Nanoparticlesmentioning

confidence: 99%

“…The drug loading capacity and drug loading efficiency of SB‐DAS‐APBA micelles on insulin were 15.7% and 42.3%, respectively. Increasing glucose content stimulated insulin release (Wen et al., 2017; Wen et al., 2018). OSA‐DBS‐100% vesicles had a higher loading rate for insulin, and the DLE and DLC of insulin were 66.8 and 13.36%, respectively (Chang et al., 2019).…”

Section: Applications Of Starch‐based Nanoparticlesmentioning

confidence: 99%

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Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Wang

et al. 2020

Comp Rev Food Sci Food Safe

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In recent years, starch‐based nanoparticles have attracted great interest due to their small size, good biocompatibility, and environmental friendliness, as well as their potential applications in foods, drug delivery carriers, and biodegradable edible films. Compared with nonstarch polysaccharides, starch can be enzymatically hydrolyzed into glucose in vivo, so it can be used as an enzyme‐responsive carrier. The recent research progress of starch‐based nanoparticles, including starch nanoparticles, starch nanospheres, starch micelles, starch vesicles, starch nanogels, and starch nanofibers, are reviewed in this paper. The main focus is on their responsiveness, digestibility, toxicity, interactions with other components, and applications. Starch‐based nanoparticles are nontoxic and responsive to pH, temperature, light, and other stimuli. It can interact with proteins, antioxidants, and lipids through electrostatic interactions and hydrogen bonding interactions. Starch‐based nanoparticles have a wide range of applications, including enhancing the mechanical properties of films and gels, stabilizing emulsions, as a fluorescent indicator, a catalyst, and a nanocarrier to control the release of active ingredients and drugs.

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Section: Stimuli‐responsive Starch‐based Nanoparticlesmentioning

confidence: 99%

Section: Digestibility and Toxicity Of Starch‐based Nanoparticlesmentioning

confidence: 99%

Section: Applications Of Starch‐based Nanoparticlesmentioning

confidence: 99%

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Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Wang

et al. 2020

Comp Rev Food Sci Food Safe

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“…The pH of human physiological is 7.4, and the PBA and its derivatives have a high pKa (of about 8–9) generally 28. Under normal physiological environment, PBA polymer has poor water solubility and weak glucose responsiveness 29. To reduce the pKa value of PBA, two main methods have been adopted: one is to introduce a pull electron group on the benzene ring of PBA, and the other is to introduce benzenoboric acid into the copolymer 30.…”

Section: Resultsmentioning

confidence: 99%

<p>Glucose-Sensitive Nanoparticles Based On Poly(3-Acrylamidophenylboronic Acid-Block-N-Vinylcaprolactam) For Insulin Delivery</p>

Wu¹,

Yang²,

Li³

et al. 2019

IJN

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BackgroundCompared with random copolymers, block copolymerization is easier to prepare for nanoparticles with core-shell structure, and they will have better glucose sensitivity and higher insulin loading.PurposeIn our study, insulin-loaded poly (3-acrylamidophenylboronic acid-block-N-vinyl caprolactam) p(AAPBA-b-NVCL) nanoparticles were successfully prepared and were glucose-sensitive, which could effectively lower the blood sugar levels within 72 hrs.MethodsThe polymer of p(AAPBA-b-NVCL) was produced by reversible addition-fragmentation chain transfer polymerization based on different ratios of 3-acrylamidophenylboronic acid (AAPBA) and N-vinylcaprolactam (NVCL), and its structure was discussed by Fourier transform infrared spectroscopy and 1H-nuclear magnetic resonance . Next, the polymer was manufactured into the nanoparticles, and the characteristics of nanoparticles were detected by dynamic light scattering, lower critical solution temperature, and transmission electron microscopy. After that, the cell and animal toxicity of nanoparticles were also investigated.ResultsThe results demonstrated that p(AAPBA-b-NVCL) was successfully synthesized, and can be easily self-assembled to form nanoparticles. The new nanoparticles included monodisperse submicron particles, with the size of the nanoparticle ranged between 150 and 300nm and are glucose- and temperature-sensitive. Meanwhile, insulin can be easily loaded by p(AAPBA-b-NVCL) nanoparticles and an effective sustained release of insulin was observed when the nanoparticles were placed in physiological saline. Besides, MTT assay revealed that cell viability was more than 80%, and mice demonstrated no negative impact on blood biochemistry and heart, liver, spleen, lung, and kidney after intraperitoneal injection of 10 mg/kg/d of nanoparticles. This suggested that the nanoparticles were low-toxic to both cells and animals. Moreover, they could lower the blood sugar level within 72h.ConclusionOur research suggested that these p(AAPBA-b-NVCL) nanoparticles might have the potential to be applied in a delivery system for insulin or other hypoglycemic proteins.

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“…Another amphiphilic glucose-sensitive dialdehyde starch polymer containing 3-aminophenylboronic acid (APBA) as a glucose-responsive group and mPEGylated dialdehyde starch (mPEG-DAS) with hydrophobic 7-hydroxycoumarin-4-acetic acid (Cou) was synthesized by Wen et al and used for the preparation of insulin-loaded micelles by a sonication method [ 94 ]. The conjugation of Cou decreased the micellar size from 241.4 to 177.9 nm, and the C.M.C.…”

Section: Micellar Drug Delivery Systems Based On Polysaccharidesmentioning

confidence: 99%

Micellar Drug Delivery Systems Based on Natural Biopolymers

Atanase

2021

Polymers

160

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The broad diversity of structures and the presence of numerous functional groups available for chemical modifications represent an enormous advantage for the development of safe, non-toxic, and cost-effective micellar drug delivery systems (DDS) based on natural biopolymers, such as polysaccharides, proteins, and peptides. Different drug-loading methods are used for the preparation of these micellar systems, but it appeared that dialysis is generally recommended, as it avoids the formation of large micellar aggregates. Moreover, the preparation method has an important influence on micellar size, morphology, and drug loading efficiency. The small size allows the passive accumulation of these micellar systems via the permeability and retention effect. Natural biopolymer-based micellar DDS are high-value biomaterials characterized by good compatibility, biodegradability, long blood circulation time, non-toxicity, non-immunogenicity, and high drug loading, and they are biodegraded to non-toxic products that are easily assimilated by the human body. Even if some recent studies reported better antitumoral effects for the micellar DDS based on polysaccharides than for commercial formulations, their clinical use is not yet generalized. This review is focused on the studies from the last decade concerning the preparation as well as the colloidal and biological characterization of micellar DDS based on natural biopolymers.

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Novel amphiphilic glucose-responsive modified starch micelles for insulin delivery

Abstract: Glucose-responsive micelles with Schiff-based was reported, which had excellent stability and biocompatibility. The release of the insulin accelerated in high glucose concentration due to the highly sensitive of glucose in physiological conditions.

Cited by 24 publications

References 60 publications

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

<p>Glucose-Sensitive Nanoparticles Based On Poly(3-Acrylamidophenylboronic Acid-Block-N-Vinylcaprolactam) For Insulin Delivery</p>

Micellar Drug Delivery Systems Based on Natural Biopolymers

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