Novel Analgesic Triglycerides from Cultures of Agaricus macrosporus and Other Basidiomycetes as Selective Inhibitors of Neurolysin

Stadler, Marc; Hellwig, Veronika; Mayer‐Bartschmid, Anke; Denzer, D. J.; Wiese, Burkhard; Burkhardt, Nils

doi:10.1038/ja.2005.105

Cited by 26 publications

(28 citation statements)

References 25 publications

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“…However the ECC and EGF did not show significantly expectative antinociceptive effect. Although Marc Stadler [2] reported that acetone extract from several edible mushrooms of basidiomycetes, showed antinociceptive effect, not all the acetone extract from edible mushrooms of basidiomycete show analgesic actions. As an edible mushroom of basidiomycetes, acetone extract of Ganoderma lucidum, showed potent antinociceptive activity.…”

Section: Resultsmentioning

confidence: 99%

“…Although Marc Stadler [2] reported that acetone extract from several edible mushrooms of basidiomycetes, showed antinociceptive effect, the acetone extract from Coprinus comatus and Grifola frondosa did not show the expectative antinociceptive effect. …”

Section: Discussionmentioning

confidence: 99%

“…Some further mushroom extracts and compounds have been found with special central effects that could be of pharmacological interest. Marc Stadler [2] reported that acetone extract from several edible mushrooms of basidiomycetes, showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism. There have been report that the anti-inflammatory and antinociceptive properties of the methanol extract of I. obliquus may be due to the inhibition of inducible nitric oxide (NO) synthase (iNOS) and cyclooxygenase-2 (COX-2) expression via the downregulation of nuclear factor kappaB (NF-kappaB) binding activity [3].…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of Antinociceptive Activity of Mycelial Extract from Three Species of Fungi of Basidiomycetes

Han¹

2009

TOALTMEDJ

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Abstract:The antinociceptive activity of mycelial extract from fermented mushroom of Ganoderma lucidum Coprinus comatus and Grifola frondosa were studied in this paper. The writhing test, formalin test and hot-plate test were used to evaluate the antinociceptive activity of the acetone extracts of the three Species of Fungi of Basidiomycetes in the study respectively. The extract of Ganoderma lucidum inhibited in a dose-dependent manner the acetic acid-induced abdominal constrictions in mice (p<0.05). Also both phases of the response were significantly inhibited in the formalin test (p<0.05). In the hot-plate test, results showed that extract of Ganoderma lucidum significantly inhibited the reaction time to thermal stimuli at 30, 60, and 90 min (p<0.05). The preliminary toxicologic study demonstrated the safety of it. However the extract from fermented mushroom of Coprinus comatus and Grifola frondosa did not show significantly expectative antinociceptive effect. Our results show the acetone extract of Ganoderma lucidum is a potent analgesic drug.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Comparison of Antinociceptive Activity of Mycelial Extract from Three Species of Fungi of Basidiomycetes

Han¹

2009

TOALTMEDJ

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“…They are produced in cultures of the edible mushroom. Agaricoglycerides showed strong activities against neurolysin, a protease involved in the regulation of dynorphin and neurotensin metabolism, and even exhibited moderate analgesic in vivo activities in an in vivo model [6,7]. The objectives of the present study were to demonstrate whether the mixture of agaricoglycerides extracted from G. frondosa (AGF) presents anti-inflammatory and antinociceptive properties.…”

Section: Introductionmentioning

confidence: 96%

Pharmacological and Pharmacokinetic Studies with Agaricoglycerides, Extracted from Grifola frondosa, in Animal Models of Pain and Inflammation

Han

Cui²

2012

Inflammation

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The objective of the present study was to demonstrate the anti-inflammatory and antinociceptive properties of agaricoglycerides of the fermented mushroom of Grifola frondosa (AGF). The effects of AGF on interleukin-1β (IL-1β) levels, tumor necrosis factor-α (TNF-α) levels, nuclear factor kappa B (NF-κB) levels, intercellular adhesion molecule-1 (ICAM-1) levels, cyclooxygenase-2 (COX-2) levels, and inducible nitric oxide synthase (iNOS) levels were determined by ELISA. The antinociceptive effects of AGF were also analyzed in acetic acid-induced pain model and formalin-induced inflammatory pain model, respectively. At the same time, the pharmacokinetic assay of AGF was also made. AGF at the dose level of 500 mg/kg significantly inhibited LPS-induced upregulation of NF-κB activation and the production of IL-1β, TNF-α, iNOS, ICAM-1, and COX-2. Moreover, AGF at the dose level of 500 mg/kg suppressed the acetic acid-induced abdominal constrictions (p < 0.05) and the formalin-induced spontaneous nociceptive behaviors (p < 0.05) in rats. The total plasma concentrations of drug after oral administration of AGF at the dose level of 500 mg/kg led to an improvement in oral bioavailability. It accounts for the anti-inflammatory and antinociceptive activity of AGF. The present study demonstrated that AGF at the dose level of 500 mg/kg has important anti-inflammatory and antinociceptive effects in preclinical models of inflammation and in some models of pain and thus may be used as an alternative medicine for inflammatory pain.

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“…18 Nevertheless, studies dealing with TAGs in mushrooms are rather scarce and based on highly specific features, for instance, the neurolysin inhibitory ability of agaricoglycerides (a class of aromatic triacylglycerols) produced by some Basidiomycetes. 19 The evaporative light-scattering detector (ELSD) is a mass-sensitive detector that responds to any analyte less volatile than the mobile phase, which is a suitable solution for TAG analysis. It has a low background signal and a nonspecific response (unlike a flame ionization detector), is compatible with gradient elution (unlike a refraction index (RI) detector) and with a broad range of solvents, and has a signal independent of the degree of saturation and chain length (unlike an ultraviolet detector).…”

Section: ■ Introductionmentioning

confidence: 99%

Triacylglycerol Profile as a Chemical Fingerprint of Mushroom Species: Evaluation by Principal Component and Linear Discriminant Analyses

Barreira

Ferreira

Oliveira

2012

J. Agric. Food Chem.

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Mushrooms are becoming relevant foods due to their nutritional, gastronomic, and pharmacological properties, namely, antioxidant, antitumor, and antimicrobial properties. However, although several mushroom species have been chemically characterized, the evaluation of the triacylglycerol (TAG) profile remains nearly unknown. Because TAG was formerly used to assess the authentication of highly valued commercial oils, and the distribution of fatty acids on the glycerol molecule is genetically controlled, the potential of the TAG profile to act as a taxonomical marker was evaluated in 30 wild mushroom species. Principal component analysis and linear discriminant analysis were used to verify the taxonomical rank (order, family, genus, or species) more related with the detected TAG profile. The results pointed out that the ability of the TAG profile to discriminate mushroom samples increased for the lower taxonomical ranks, reaching a maximal performance for species discrimination. Because there is a high resemblance among mushroom species belonging to the same genus and considering that conservation techniques applied to mushrooms often change their physical properties, this might be considered as a valuable outcome with important practical applications.

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Novel Analgesic Triglycerides from Cultures of Agaricus macrosporus and Other Basidiomycetes as Selective Inhibitors of Neurolysin

Cited by 26 publications

References 25 publications

A Comparison of Antinociceptive Activity of Mycelial Extract from Three Species of Fungi of Basidiomycetes

A Comparison of Antinociceptive Activity of Mycelial Extract from Three Species of Fungi of Basidiomycetes

Pharmacological and Pharmacokinetic Studies with Agaricoglycerides, Extracted from Grifola frondosa, in Animal Models of Pain and Inflammation

Triacylglycerol Profile as a Chemical Fingerprint of Mushroom Species: Evaluation by Principal Component and Linear Discriminant Analyses

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