Novel and neglected issues of acetone–butanol–ethanol (ABE) fermentation by clostridia: Clostridium metabolic diversity, tools for process mapping and continuous fermentation systems

Patáková, Petra; Linhová, Michaela; Rychtera, M.; Paulová, Leona; Melzoch, Karel

doi:10.1016/j.biotechadv.2012.01.010

Cited by 121 publications

(72 citation statements)

References 98 publications

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“…It was observed that the most favorable Clostridium species, C. acetobutylicum and C. beijerinckii, have the same metabolic pathways (Zheng et al 2009b), with the main products being solvents (butanol, acetone, and ethanol), acids (acetic acid and butyric acid), and gases (CO 2 and H 2 ). Detailed descriptions of metabolic pathways and their probable modifications can be found elsewhere (Dusséaux et al 2013;Ezeji et al 2010;García et al 2011;Jin et al 2011;Jurgens et al 2012;Lee et al 2012;Lütke-Eversloh and Bahl 2011;Patakova et al 2013). In general, metabolic pathways can be broadly divided into two phases: acidogenic and solventogenic.…”

Section: Metabolic Effects Of Inhibitorsmentioning

confidence: 99%

“…This figure is created using the information presented in previous review conducted on ethanologenic bacteria(Ibraheem and Ndimba 2013), and several studies related to ABE fermentation(Abdehagh et al 2014;Dusséaux et al 2013;Ezeji et al 2010;García et al 2011;Jin et al 2011;Jurgens et al 2012;Lee et al 2012;Lütke-Eversloh and Bahl 2011;Patakova et al 2013;Ujor et al 2014). Generally, microbes give first priority to make less inhibitory alcohol that causes deficit of NAD(P)Hs for solvent production…”

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confidence: 99%

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Microbial inhibitors: formation and effects on acetone-butanol-ethanol fermentation of lignocellulosic biomass

Baral

Shah

2014

Appl Microbiol Biotechnol

144

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Biobutanol is a promising biofuel due to the close resemblance of its fuel properties to gasoline, and it is produced via acetone-butanol-ethanol (ABE) fermentation using Clostridium species. However, lignin in the crystalline structure of the lignin-cellulose-hemicellulose biomass complex is not readily consumed by the Clostridium; thus, pretreatment is required to degrade this complex. During pretreatment, some fractions of cellulose and hemicellulose are converted into fermentable sugars, which are further converted to ABE. However, a major setback resulting from common pretreatment processes is the formation of sugar and lignin degradation compounds, including weak acids, furan derivatives, and phenolic compounds, which have inhibitory effects on the Clostridium. In addition, butanol concentration above 13 g/L in the fermentation broth is itself toxic to most Clostridium strain(s). This review summarizes the current state-of-the-art knowledge on the formation of microbial inhibitors during the most common lignocellulosic biomass pretreatment processes. Metabolic effects of inhibitors and their impacts on ABE production, as well as potential solutions for reducing inhibitor formation, such as optimizing pretreatment process parameters, using inhibitor tolerant strain(s) with high butanol yield ability, continuously recovering butanol during ABE fermentation, and adopting consolidated bioprocessing, are also discussed.

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Section: Metabolic Effects Of Inhibitorsmentioning

confidence: 99%

mentioning

confidence: 99%

Microbial inhibitors: formation and effects on acetone-butanol-ethanol fermentation of lignocellulosic biomass

Baral

Shah

2014

Appl Microbiol Biotechnol

144

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“…Diversos estudios han demostrado que su producción por vía fermentativa se puede desarrollar empleando diferentes tipos de bacterias, pero es de interés para el presente trabajo, citar el género Clostridium especie acetobutylicum debido a que es el más empleado industrialmente: presenta mayor potencial para la producción eficiente del butanol (Jang et al, 2012;Kamiński et al, 2011;Patakova et al, 2013;Tashiro et al, 2010).…”

Section: Introductionunclassified

Análisis de estabilidad de un sistema de fermentación acetona-butanol-etanol (ABE) a partir de glucosa empleando <i>Clostridium acetobutylicum</i> ATCC 824

2014

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In the present study we analyzed the dynamics and stability in production of butanol by fermentation on a continuous bioreactor. The dynamic response of the system is studied as an evaluation criterion selecting the concentration of butanol obtained and using a kinetic model statistically validated, which describe the continuous cultures oscillatory behavior taking into account the influence of pH, inhibition by products and influencing parameters in the system. The bifurcation parameters chosen were the dilution rate (D) and feed substrate concentration (Sf). We used a calculation routine developed in Matlab ® and MATCONT ® to generate diagrams for dynamic behavior, steady state values and bifurcation diagrams. The results show that it is convenient to operate at smaller dilution rates (D <0.1 [h ^ (-1)]) and feed substrate concentrations (Sf) in the range of 40 to 90 [g / L] for higher concentrations of butanol. The practical implications of the phenomena discovered are analyzed in order to apply an appropriate methodology for this type of study and the implementation of it in bioprocesses.Keywords: Bifurcation, Butanol, Dynamic simulation, Nonlinear dynamics, Stability Analysis. ResumenSe analiza la dinámica y estabilidad en la producción de butanol por fermentación en un biorreactor continuo. La respuesta dinámica del sistema se estudió eligiendo como criterio de evaluación la concentración de butanol, en un modelo cinético validado estadísti-camente, que describe el comportamiento oscilatorio de cultivos continuos teniendo en cuenta la influencia del pH, inhibición por productos y los parámetros influyentes en el sistema. Se tomaron como paráme-

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“…Some of these bacteria are C. acetobutylicum, C. beijerinckii, C. saccharoacetobutylicum, C. aurantibutyricum, and C. sporogenes. (Kharkwal et al, 2009;Ni and Sun, 2009;Patakova et al, 2013). Among these microorganisms, two species, C. beijerinckii and C. acetobutylicum are the most promising ones for commercial and laboratory applications with high efficiency (Mo et al, 2015).…”

Section: Microorganisms For Abe Fermentationmentioning

confidence: 99%

“…Among these microorganisms, two species, C. beijerinckii and C. acetobutylicum are the most promising ones for commercial and laboratory applications with high efficiency (Mo et al, 2015). In fact, native and modified forms of these two strains are the most applied microorganisms in ABE production (Ni and Sun, 2009;Komonkiat and Cheirsilp, 2013;Patakova et al, 2013;. C. acetobutylicum is a rod-shaped, gram-positive, and obligate anaerobic bacterium that forms spores.…”

Section: Microorganisms For Abe Fermentationmentioning

confidence: 99%

Recent trends in acetone, butanol, and ethanol (ABE) production

Karimi¹,

Tabatabaei²,

Horváth³

et al. 2015

Biofuel Res. J.

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Among the renewable fuels considered as a suitable substitute to petroleum-based gasoline, butanol has attracted a great deal of attention due to its unique properties. Acetone, butanol, and ethanol (ABE) can be produced biologically from different substrates, including sugars, starch, lignocelluloses, and algae. This process was among the very first biofuel production processes which was commercialized during the First World War. The present review paper discusses the different aspects of the ABE process and the recent progresses made. Moreover, the microorganisms and the biochemistry of the ABE fermentation as well as the feedstocks used are reviewed. Finally, the challenges faced such as low products concentration and products` inhibitory effects on the fermentation are explained and different possible solutions are presented and reviewed. © 2015 BRTeam. All rights reserved.Biobutanol is an advantageous competitor to most biofuels and petroleum-based fuels. This review paper discusses the basic and applied perspective of the process.

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Novel and neglected issues of acetone–butanol–ethanol (ABE) fermentation by clostridia: Clostridium metabolic diversity, tools for process mapping and continuous fermentation systems

Cited by 121 publications

References 98 publications

Microbial inhibitors: formation and effects on acetone-butanol-ethanol fermentation of lignocellulosic biomass

Microbial inhibitors: formation and effects on acetone-butanol-ethanol fermentation of lignocellulosic biomass

Análisis de estabilidad de un sistema de fermentación acetona-butanol-etanol (ABE) a partir de glucosa empleando <i>Clostridium acetobutylicum</i> ATCC 824

Recent trends in acetone, butanol, and ethanol (ABE) production

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