Novel and simple prognostic index for nasal natural killer/T‐cell lymphoma

Abstract

Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T‐cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T‐cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C‐reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin‐2 receptor (sIL‐2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease‐specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T‐cell lymphoma. © 2013 Wiley Periodicals, Inc. Head Neck 36: 551–556, 2014

Peer Review #1 of "The pretreatment albumin to globulin ratio predicts survival in patients with natural killer/T-cell lymphoma (v0.1)"

“…B symptoms (fever, night sweats, and weight loss) are usually observed (52% in our cohort) (Chan, Jaffe & Ralfkiaer, 2001;Chan et al, 2008). In addition, high levels of inflammatory markers, such as CRP and soluble interleukin-2 receptor (sIL-2R), were found to be predictive of poor survival in NKTCL patients in previous studies (Li et al, 2013;Hanakawa et al, 2014). In the present study, NKTCL patients with low AGR experienced significant adverse clinical events, including advanced cancer stage, elevated LDH, B symptoms, multiple extranodal involvement, higher IPI and NKPI scores, and an inferior performance status.…”

The pretreatment albumin to globulin ratio predicts survival in patients with natural killer/T-cell lymphoma

“…B symptoms (fever, night sweats, and weight loss) are usually observed (52% in our cohort) ( Chan, Jaffe & Ralfkiaer, 2001 ; Chan et al, 2008 ). In addition, high levels of inflammatory markers, such as CRP and soluble interleukin-2 receptor (sIL-2R), were found to be predictive of poor survival in NKTCL patients in previous studies ( Li et al, 2013 ; Hanakawa et al, 2014 ). In the present study, NKTCL patients with low AGR experienced significant adverse clinical events, including advanced cancer stage, elevated LDH, B symptoms, multiple extranodal involvement, higher IPI and NKPI scores, and an inferior performance status.…”

Trial of LVDP regimen (l-asparaginase, etoposide, dexamethasone, and cisplatin, followed by radiotherapy) as first-line treatment for newly diagnosed, stage III/IV extranodal natural killer/T cell lymphoma

“…In addition, subgroup analysis suggested that ECOG PS, KPI, IPI, sex, and bone marrow infiltration may influence prognosis. The first three factors are widely accepted prognostic factors [13,36,39], and the fourth is worth further investigation. Bone marrow infiltration appears to have a strong prognostic effect, with a positive result indicating poor prognosis.…”