Novel antiviral activity of baicalein against dengue virus

Zandi, Keivan; Teoh, Boon‐Teong; Sam, Sing‐Sin; Wong, Pooi-Fong; Mustafa, Mohd Rais; AbuBakar, Sazaly

doi:10.1186/1472-6882-12-214

Cited by 180 publications

(143 citation statements)

References 31 publications

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“…Baicalein, quercetin and rutin are flavones. Antiviral activity of baicalein and quercetin is determined previously against DENV, JEV (Japanese encephalitis virus) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2); [35,37,38]. Quercetin also was studied for the infectivity and replication of polio-virus type 1, para-influenza virus type 3 (Pf-3), respiratory syncytial virus (RSV), porcine epidemic diarrhea virus and some types of human adenoviruses, [35,36,[39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Identification of bioflavonoid as fusion inhibitor of dengue virus using molecular docking approach

Mir

Ismatullah

Rauf

et al. 2016

Informatics in Medicine Unlocked

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Dengue virus with four distinct serotypes belongs to Flavivirus, poses a significant threat to human health and becomes an emerging global problem. Membrane fusion is central molecular event during viral entry into host cell. To prevent viral infection it is necessary to interrupt the virus replication at early stage of attachment. Dengue Virus (DENV) envelope protein experience conformational changes and it causes virus to fuse with host cell. Hinge region movement of domain I and II in envelope protein facilitates the fusion process. Small molecules that bind in this pocket may have ability to interrupt the conformational changes that trigger fusion process. We chose different flavonoids (baicalein, fisetin, hesperetin, naringenin/ naringin, quercetin and rutin) that possess anti dengue activity. Molecular docking analysis was done to examine the inhibitory effect of flavonoids against envelope protein of DENV-2. Results manifest quercetin (flavonoid found in Carica papaya, apple and even in lemon) as only flavone that can interrupt the fusion process of virus by inhibiting the hinge region movement and blocking the conformational rearrangement in envelope protein. These novel findings using computational approach are worthwhile and will be a bridge to check the efficacy of compounds using appropriate animal model under In vivo studies. This information can be used by new techniques and provides a way to control dengue virus infection.

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Section: Introductionmentioning

confidence: 99%

Identification of bioflavonoid as fusion inhibitor of dengue virus using molecular docking approach

Mir

Ismatullah

Rauf

et al. 2016

Informatics in Medicine Unlocked

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“…Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi, a plant widely used in China. Baicalein has been demonstrated to possess potent antioxidant and anti-inflammatory properties [10,11], and has a wide range of pharmacological effects, including antiviral, anti-tumour, neuroprotective and nephroprotective activity [12][13][14][15], etc. Besides, baicalein is liver-protective and alleviates hepatotoxin-induced liver injury [16,17].…”

Section: Introductionmentioning

confidence: 99%

Baicalein and its underlying mechanism as a protector against liver injury induced by cisplatin in mice

Niu

Wan

Bian

et al. 2016

Biotechnology & Biotechnological Equipment

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Cisplatin is widely used for the treatment of a variety of cancers but with a high incidence of hepatotoxicity. Baicalein is originally isolated from the root of Scutellaria baicalensis Georgi with broad bioactivities. The present study aims to investigate the protective effect of baicalein against cisplatin-induced acute liver injury and the underlying mechanism of this protective effect. Administration of cisplatin (40 mg/kg) for 24 h increased the serum alanine and aspartate aminotransferases and alkaline phosphatase levels, while baicalein could reverse all those changes induced by cisplatin. Liver histological analysis further evidenced the protection of baicalein against cisplatin-induced liver injury. Baicalein counteracted the increased liver malondialdehyde (amount induced by cisplatin, while baicalein could further increase the cisplatin-induced elevation of the amount of reduced glutathione in the liver. Further results showed that baicalein reversed the cisplatin-induced decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S transferase and glutathione reductase. On the other hand, baicalein alleviated the increase in the serum levels of tumour necrosis factor alpha and interleukin 6 induced by cisplatin. Taken together, our results demonstrate that baicalein can inhibit cisplatininduced hepatic oxidative stress and inflammation, which contributes greatly to the amelioration of cisplatin-induced liver injury.

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“…9,10,25 Nevertheless, these types of compounds commonly show a low bioavailability, especially for therapeutic uses, the reason why several strategies to overcome this limitation focus on the use of a wide variety of nanocarriers, including liposomes, solid lipid nanoparticles, nanoemulsions and nanocrystals, or polymeric nanoparticles, among others. 26 Liposomal formulations have shown interesting properties in terms of the effective antiviral dose, decreasing the toxic concentrations and enhancing the retention time of the drug in blood circulation (due to pegylation).…”

Section: Antiviral Drugsmentioning

confidence: 99%

“…9 Flavonoids, fisetin, quercetin and baicalein, also exhibited anti-dengue virus activities ( Figure 1). 10 The first major success of the sterile insect technique was achieved against Culex quinquefasciatus in Myanmar in 1967 and efforts were being made against Culex quinquefasciatus and Ae. aegypti in India in 1967 and, recently in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Nanobiotechnology Solutions againstAedes aegypti

Islan

Durán

Castro

2016

Journal of the Brazilian Chemical Society

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United Nations Children's Fund (UNICEF)/United Nations Development Programme (UNDP)/ World Bank/World Health Organization (WHO) implemented the Training in Tropical Diseases (TDR) program with excellent results; however, due to current challenges, this active program requires new and innovative solutions. Nowadays, Aedes aegyptis-borne diseases can be added among neglected diseases. Surveillance and control must be considered owing to a great risk of infection with dengue, chikungunya and zika viruses. Although investigations on several vaccines are in progress, new insights in term of development of drugs that evade from resistance are of paramount importance. Nanobiotechnology appears as one of the most innovative strategy in the search of new uses for old pharmaceuticals or in the development of innovative and intelligent nanomedicines for neglected diseases. Liposomes, solid lipid nanoparticles, nanoemulsions, polymeric nanoparticles, metallic nanoparticles, quantum dots, carbon dots and carbon nanotubes were the focus of the current advances. In this direction, we have focused this overview on new advances in diagnostic assays as nanobiosensors, antivirus and nanoinsecticides on Aedes aegyptis control.

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Novel antiviral activity of baicalein against dengue virus

Cited by 180 publications

References 31 publications

Identification of bioflavonoid as fusion inhibitor of dengue virus using molecular docking approach

Identification of bioflavonoid as fusion inhibitor of dengue virus using molecular docking approach

Baicalein and its underlying mechanism as a protector against liver injury induced by cisplatin in mice

Nanobiotechnology Solutions againstAedes aegypti

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